Stable redox compositions and methods of use

• US 10,292,911 B1
• Filed: 09/07/2018
• Issued: 05/21/2019
• Est. Priority Date: 12/22/2017
• Status: Active Grant

• Current Assignee: Reoxcyn, LLC
• Original Assignee: Reoxcyn, LLC
• Inventors: Richards, Kurt
• Primary Examiner(s): Arnold, Ernst V
• Application Number:
  US16/125,344
• Time in Patent Office: 256 Days
• CPC Class Codes: A61K 2800/83 Electrophoresis; Electrodes; Electrolytic phenomena
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/20 Halogens; Compounds thereof
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61K 8/26 Aluminium; Compounds thereof
• CPC Class Codes: A61K 8/891 saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
• CPC Class Codes: A61K 8/965 of inanimate origin
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61K 9/0095 Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

Described herein are compositions that include a saline solution and reactive oxygen species. Specifically, the composition may include a saline solution, reactive oxygen species, an emollient, and a pH modifier. Also provided is a gel composition that includes a rheology agent. Also provided are methods of making and using the compositions.

Claims

1. A composition, comprising:

an electrolyzed saline solution, the electrolyzed saline comprising a salt, and the salt comprising;

aluminum in an amount of 32.473 ppm to 241.700 ppm,

calcium in an amount of 1290 ppm to 2101 ppm,

iron in an amount of 23.292 ppm to 141.400 ppm,

lead in an amount of 0.077 ppm to 0.210 ppm,

magnesium in an amount of 217.9 ppm to 1944.0 ppm,

potassium in an amount of 149.3 ppm to 1728.0 ppm, and

strontium in an amount of 11.251 ppm to 32.223 ppm;

a reactive oxygen species;

an emollient; and

a pH modifier.

2. The composition of claim 1, wherein the electrolyzed saline solution comprises salt in an amount of about 0.01% to about 1% w/v.

3. The composition of claim 2, wherein the salt is present in an amount of about 0.05% w/v.

4. The composition of claim 2, wherein the salt is raw, unprocessed salt.

5. The composition of claim 2, wherein the salt is Himalayan sea salt.

6. The composition of claim 1, wherein the reactive oxygen species is hypochlorite.

7. The composition of claim 1, wherein the reactive oxygen species is present in an amount of about 5 to about 100 ppm.

8. The composition of claim 1, wherein the emollient is a silicone polymer.

9. The composition of claim 8, wherein the silicone polymer is dimethicone, cyclomethicone, or a blend thereof.

10. The composition of claim 1, wherein the emollient is present in an amount of about 0.5% to about 10% w/v.

11. The composition of claim 1, wherein the pH modifier is sodium phosphate monobasic.

12. The composition of claim 1, wherein the pH modifier is present in an amount of about 0.05% to about 5% w/v.

13. The composition of claim 1, further comprising a rheology agent.

14. The composition of claim 13, wherein the rheology agent is a metal silicate.

15. The composition of claim 14, wherein the metal silicate is sodium magnesium silicate.

16. The composition of claim 13, wherein the rheology agent is present in an amount of about 0.5% to about 10% w/v.

17. The composition of claim 1, wherein the composition is in the form of a gel, sol, sol-gel, hydrogel, cream, foam, balm, liniment, unguent, colloid, emulsion, dispersion, salve, emollient, lotion, meltable solid, mousse, ointment, paste, serum, solution, spray, stick, liquid, or suspension.

20. A method of making a composition of claim 1, the method comprising electrolyzing a saline solution to generate reactive oxygen species and providing an emollient, and mixing the electrolyzed saline solution and emollient to form a composition.

21. The method of claim 20, further comprising providing a rheology agent and mixing the ingredients to form a gel composition, wherein the rheology agent is provided in an amount sufficient generate a gel composition having a viscosity of about 100 to about 100,000 centipoise (cP).

18. A composition, comprising:

an electrolyzed saline solution comprising salt in an amount of about 0.05% w/v, wherein the salt comprises;

aluminum in an amount of 32.473 ppm to 241.700 ppm,

calcium in an amount of 1290 ppm to 2101 ppm,

iron in an amount of 23.292 ppm to 141.400 ppm,

lead in an amount of 0.077 ppm to 0.210 ppm,

magnesium in an amount of 217.9 ppm to 1944.0 ppm,

potassium in an amount of 149.3 ppm to 1728.0 ppm, and

strontium in an amount of 11.251 ppm to 32.223 ppm;

hypochlorite in an amount of about 72 ppm;

dimethicone in an amount of about 5%; and

sodium phosphate monobasic in an amount of about 0.3% w/v.

19. A gel composition, comprising:

an electrolyzed saline solution comprising salt in an amount of about 0.05% w/v, wherein the salt comprises;

aluminum in an amount of 32.473 ppm to 241.700 ppm,

calcium in an amount of 1290 ppm to 2101 ppm,

iron in an amount of 23.292 ppm to 141.400 ppm,

lead in an amount of 0.077 ppm to 0.210 ppm,

magnesium in an amount of 217.9 ppm to 1944.0 ppm,

potassium in an amount of 149.3 ppm to 1728.0 ppm, and

strontium in an amount of 11.251 ppm to 32.223 ppm;

hypochlorite in an amount of about 72 ppm;

sodium magnesium silicate in an amount of about 3.25%;

dimethicone in an amount of about 5%; and

sodium phosphate monobasic in an amount of about 0.3% w/v.