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Methods for increasing blood plasma 2′-deoxyuridine (dUrd) and thymidylate synthase inhibition

  • US 10,292,984 B2
  • Filed: 02/09/2018
  • Issued: 05/21/2019
  • Est. Priority Date: 02/14/2017
  • Status: Active Grant
First Claim
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1. A method of increasing plasma concentration of 2′

  • -deoxyuridine (dUrd) in a human subject comprising;

    a. a step of administering 500 mg/m2 5-fluorouracil (5-FU) intravenously as a bolus injection to said human subject;

    b. following (a), a step of administering 30, 60, 120, or 240 mg/m2 [6R]-5, 10-methylene tetrahydrofolate (6R-MTHF) intravenously as one or more bolus injections to said human subject; and

    c. optionally administering a therapeutically effective amount of at least one anticancer agent selected from the group consisting of oxaliplatin, irinotecan, and bevacizumab;

    wherein said administration produces an increased plasma concentration of dUrd relative to dUrd plasma concentration in a human subject following administration of an equimolar dose of 5-formyl tetrahydrofolate (LV).

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