Peptide therapeutics and methods for using same
First Claim
Patent Images
1. A composition comprising the mitochondria penetrating peptide (MPP) Cha-Arg-Cha-Lys-NH2 alone or in combination with one or more aromatic-cationic peptides selected from the group consisting of:
- 2′
6′
-Dmp-D-Arg-2′
6′
-Dmt-Lys-NH2;
2′
,6′
-Dmt-D-Arg-Phe-Lys-NH2;
2′
6′
-Dmp-D-Arg-Phe-Lys-NH2;
2′
6′
-Dmt-D-Arg-PheOrn-NH2;
2′
6′
-Dmt-D-Arg-Phe-Ahp(2-aminoheptanoicacid)-NH2;
2′
6′
-Dmt-D-Arg-Phe-Lys-NH2;
2′
6′
-Dmt-D-Cit-PheLys-NH2;
Ala-D-Phe-D-Arg-Tyr-Lys-D-Trp-His-D-Tyr-Gly-Phe;
Arg-D-Dmt-Arg-NH2;
Arg-D-Dmt-Lys-NH2;
Arg-D-Dmt-NH2;
Arg-D-Leu-D-Tyr-Phe-Lys-Glu-D-Lys-Arg-D-Trp-Lys-D-Phe-Tyr-D-Arg-Gly;
Arg-D-Tyr-Arg-NH2;
Arg-D-Tyr-Lys-NH2;
Arg-D-Tyr-NH2;
Asp-Arg-D-Phe-Cys-Phe-D-Arg-D-Lys-Tyr-Arg-D-Tyr-Trp-D-His-Tyr-D-Phe-Lys-Phe;
Asp-D-Trp-Lys-Tyr-D-His-Phe-Arg-D-Gly-Lys-NH2;
D-Arg-2′
6′
-Dmt-Lys-Phe-NH2;
D-Arg-Arg-Dmt-Phe-NH2;
D-Arg-Arg-Tyr-Phe-NH2;
D-Arg-Cha-Lys-Cha-NH2;
D-Arg-Cha-Lys-NH2;
D-Arg-D-Dmt-NH2;
D-Arg-Dmt-D-Lys-Phe-NH2;
D-Arg-Dmt-Lys-Dmt-Lys-Met-NH2;
D-Arg-Dmt-Lys-Dmt-Lys-Trp-NH2;
D-Arg-Dmt-Lys-D-Phe-NH2;
D-Arg-Dmt-Lys-NH2;
D-Arg-Dmt-Lys-Phe-Lys-Met-NH2;
D-Arg-Dmt-Lys-Phe-Lys-Trp-NH2;
D-Arg-Dmt-Lys-Phe-Met-NH2;
D-Arg-Dmt-Lys-Trp-NH2;
D-Arg-Dmt-NH2;
D-Arg-Dmt-Phe-NH2;
D-Arg-D-Tyr-D-Lys-D-Phe-NH2;
D-Arg-D-Tyr-Lys-Phe-NH2;
D-Arg-D-Tyr-NH2;
D-Arg-Phe-Lys-NH2;
D-Arg-Trp-Lys-NH2;
D-Arg-Trp-Lys-Trp-NH2;
D-Arg-Tyr-D-Lys-Phe-NH2;
D-Arg-Tyr-Lys-D-Phe-NH2;
D-Arg-Tyr-Lys-NH2;
D-Arg-Tyr-Lys-Phe-NH2;
D-Arg-Tyr-NH2;
D-Arg-Tyr-Phe-NH2;
D-Dmt-Arg-NH2;
D-Glu-Asp-Lys-D-Arg-D-His-Phe-Phe-D-Val-Tyr-Arg-Tyr-D-Tyr-Arg-His-Phe-NH2;
D-His-Glu-Lys-Tyr-D-Phe-Arg;
D-His-Lys-Tyr-D-Phe-Glu-D-Asp-D-Asp-D-His-D-Lys-Arg-Trp-NH2;
Dmt-D-Arg-NH2;
Dmt-D-Phe-Arg-Lys-NH2;
Dmt-Lys-D-Phe-NH2;
Dmt-Lys-NH2;
Dmt-Lys-Phe-NH2;
D-Nle-Cha-Ahe-Cha-NH2;
D-Nle-Dmt-Ahe-Phe-NH2;
D-Phe-D-Arg-D-Phe-D-Lys-NH2;
D-Tyr-Arg-NH2;
D-Tyr-Trp-Lys-NH2;
Glu-Arg-D-Lys-Tyr-D-Val-Phe-D-His-Trp-Arg-D-Gly-Tyr-Arg-D-Met-NH2;
Gly-Ala-Lys-Phe-D-Lys-Glu-Arg-Tyr-His-D-Arg-D-Arg-Asp-Tyr-Trp-D-His-Trp-His-D-Lys-Asp;
Gly-D-Phe-Lys-His-D-Arg-Tyr-NH2;
H-D-Arg(Nα
Me)-Dmt(NMe)-Lys(Nα
Me)-Phe(NMe)-NH2;
H-D-Arg-Dmt-Lys(Nα
Me)-Phe(NMe)-NH2;
H-D-Arg-Dmt-Lys(Nα
Me)-Phe-NH2;
H-D-Arg-Dmt-Lys-Phe(NMe)-NH2;
H-D-Arg-Dmt-Lys-Phe-Sar-Gly-Cys-NH2;
H-D-Arg-Dmt-LysΨ
[CH2-NH]Phe-NH2;
H-D-Arg-Dmt-Ψ
[CH2-NH]Lys-Phe-NH2;
H-D-Arg-Dmt-Ψ
[CH2-NH]Lys-Ψ
[CH2-NH]Phe-NH2;
H-D-Arg-Ψ
[CH2-NH]Dmt-Lys-Phe-NH2;
His-Tyr-D-Arg-Trp-Lys-Phe-D-Asp-Ala-Arg-Cys-D-Tyr-His-Phe-D-Lys-Tyr-His-Ser-NH2;
Lys-D-Arg-Tyr-NH2;
Lys-D-Gln-Tyr-Arg-D-Phe-Trp-NH2;
Lys-Dmt-D-Arg-NH2;
Lys-D-Phe-Arg-Dmt-NH2;
Lys-D-Phe-Arg-Tyr-NH2;
Lys-Phe-NH2;
Lys-Trp-D-Tyr-Arg-Asn-Phe-Tyr-D-His-NH2;
Met-Tyr-D-Arg-Phe-Arg-NH2;
Met-Tyr-D-Lys-Phe-Arg;
Phe-Arg-D-His-Asp;
Phe-D-Arg-2′
6′
-Dmt-Lys-NH2;
Phe-D-Arg-D-Phe-Lys-NH2;
Phe-D-Arg-His;
Phe-D-Arg-Lys-Trp-Tyr-D-Arg-His;
Phe-D-Arg-Phe-D-Lys-NH2;
Phe-D-Arg-Phe-Lys-NH2;
Phe-D-Dmt-Arg-Lys-NH2;
Phe-D-Tyr-Arg-Lys-NH2;
Phe-Lys-Dmt-NH2;
Phe-Phe-D-Tyr-Arg-Glu-Asp-D-Lys-Arg-D-Arg-His-Phe-NH2;
Phe-Tyr-Lys-D-Arg-Trp-His-D-Lys-D-Lys-Glu-Arg-D-Tyr-Thr;
Thr-Gly-Tyr-Arg-D-His-Phe-Trp-D-His-Lys;
Thr-Tyr-Arg-D-Lys-Trp-Tyr-Glu-Asp-D-Lys-D-Arg-His-Phe-D-Tyr-Gly-Val-Ile-D-His-Arg-Tyr-Lys-NH2;
Trp-D-Lys-Tyr-Arg-NH2;
Trp-Lys-Phe-D-Asp-Arg-Tyr-D-His-Lys;
Tyr-Asp-D-Lys-Tyr-Phe-D-Lys-D-Arg-Phe-Pro-D-Tyr-His-Lys;
Tyr-D-Arg-NH2;
Tyr-D-Arg-Phe-Lys-Glu-NH2;
Tyr-D-Arg-Phe-Lys-NH2;
Tyr-D-His-Phe-D-Arg-Asp-Lys-D-Arg-His-Trp-D-His-Phe;
Tyr-D-Phe-Arg-Lys-NH2;
Tyr-His-D-Gly-Met; and
Val-D-Lys-His-Tyr-D-Phe-Ser-Tyr-Arg-NH2,and further comprising one or more additional active agents selected from the group consisting of cyclosporine, a cardiac drug, an anti-inflammatory, an anti-hypertensive drug, an antibody, an ophthalmic drug, an antioxidant, a metal complexer, and an antihistamine.
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Accused Products
Abstract
Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of an MPP, and/or naturally or artificially occurring variants or analogs of an MPP, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide such as D-Arg-2′6′-Dmt-Lys-Phe-NH2).
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Citations
5 Claims
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1. A composition comprising the mitochondria penetrating peptide (MPP) Cha-Arg-Cha-Lys-NH2 alone or in combination with one or more aromatic-cationic peptides selected from the group consisting of:
-
2′
6′
-Dmp-D-Arg-2′
6′
-Dmt-Lys-NH2;2′
,6′
-Dmt-D-Arg-Phe-Lys-NH2;2′
6′
-Dmp-D-Arg-Phe-Lys-NH2;2′
6′
-Dmt-D-Arg-PheOrn-NH2;2′
6′
-Dmt-D-Arg-Phe-Ahp(2-aminoheptanoicacid)-NH2;2′
6′
-Dmt-D-Arg-Phe-Lys-NH2;2′
6′
-Dmt-D-Cit-PheLys-NH2;Ala-D-Phe-D-Arg-Tyr-Lys-D-Trp-His-D-Tyr-Gly-Phe; Arg-D-Dmt-Arg-NH2; Arg-D-Dmt-Lys-NH2; Arg-D-Dmt-NH2; Arg-D-Leu-D-Tyr-Phe-Lys-Glu-D-Lys-Arg-D-Trp-Lys-D-Phe-Tyr-D-Arg-Gly; Arg-D-Tyr-Arg-NH2; Arg-D-Tyr-Lys-NH2; Arg-D-Tyr-NH2; Asp-Arg-D-Phe-Cys-Phe-D-Arg-D-Lys-Tyr-Arg-D-Tyr-Trp-D-His-Tyr-D-Phe-Lys-Phe; Asp-D-Trp-Lys-Tyr-D-His-Phe-Arg-D-Gly-Lys-NH2; D-Arg-2′
6′
-Dmt-Lys-Phe-NH2;D-Arg-Arg-Dmt-Phe-NH2; D-Arg-Arg-Tyr-Phe-NH2; D-Arg-Cha-Lys-Cha-NH2; D-Arg-Cha-Lys-NH2; D-Arg-D-Dmt-NH2; D-Arg-Dmt-D-Lys-Phe-NH2; D-Arg-Dmt-Lys-Dmt-Lys-Met-NH2; D-Arg-Dmt-Lys-Dmt-Lys-Trp-NH2; D-Arg-Dmt-Lys-D-Phe-NH2; D-Arg-Dmt-Lys-NH2; D-Arg-Dmt-Lys-Phe-Lys-Met-NH2; D-Arg-Dmt-Lys-Phe-Lys-Trp-NH2; D-Arg-Dmt-Lys-Phe-Met-NH2; D-Arg-Dmt-Lys-Trp-NH2; D-Arg-Dmt-NH2; D-Arg-Dmt-Phe-NH2; D-Arg-D-Tyr-D-Lys-D-Phe-NH2; D-Arg-D-Tyr-Lys-Phe-NH2; D-Arg-D-Tyr-NH2; D-Arg-Phe-Lys-NH2; D-Arg-Trp-Lys-NH2; D-Arg-Trp-Lys-Trp-NH2; D-Arg-Tyr-D-Lys-Phe-NH2; D-Arg-Tyr-Lys-D-Phe-NH2; D-Arg-Tyr-Lys-NH2; D-Arg-Tyr-Lys-Phe-NH2; D-Arg-Tyr-NH2; D-Arg-Tyr-Phe-NH2; D-Dmt-Arg-NH2; D-Glu-Asp-Lys-D-Arg-D-His-Phe-Phe-D-Val-Tyr-Arg-Tyr-D-Tyr-Arg-His-Phe-NH2; D-His-Glu-Lys-Tyr-D-Phe-Arg; D-His-Lys-Tyr-D-Phe-Glu-D-Asp-D-Asp-D-His-D-Lys-Arg-Trp-NH2; Dmt-D-Arg-NH2; Dmt-D-Phe-Arg-Lys-NH2; Dmt-Lys-D-Phe-NH2; Dmt-Lys-NH2; Dmt-Lys-Phe-NH2; D-Nle-Cha-Ahe-Cha-NH2; D-Nle-Dmt-Ahe-Phe-NH2; D-Phe-D-Arg-D-Phe-D-Lys-NH2; D-Tyr-Arg-NH2; D-Tyr-Trp-Lys-NH2; Glu-Arg-D-Lys-Tyr-D-Val-Phe-D-His-Trp-Arg-D-Gly-Tyr-Arg-D-Met-NH2; Gly-Ala-Lys-Phe-D-Lys-Glu-Arg-Tyr-His-D-Arg-D-Arg-Asp-Tyr-Trp-D-His-Trp-His-D-Lys-Asp; Gly-D-Phe-Lys-His-D-Arg-Tyr-NH2; H-D-Arg(Nα
Me)-Dmt(NMe)-Lys(Nα
Me)-Phe(NMe)-NH2;H-D-Arg-Dmt-Lys(Nα
Me)-Phe(NMe)-NH2;H-D-Arg-Dmt-Lys(Nα
Me)-Phe-NH2;H-D-Arg-Dmt-Lys-Phe(NMe)-NH2; H-D-Arg-Dmt-Lys-Phe-Sar-Gly-Cys-NH2; H-D-Arg-Dmt-LysΨ
[CH2-NH]Phe-NH2;H-D-Arg-Dmt-Ψ
[CH2-NH]Lys-Phe-NH2;H-D-Arg-Dmt-Ψ
[CH2-NH]Lys-Ψ
[CH2-NH]Phe-NH2;H-D-Arg-Ψ
[CH2-NH]Dmt-Lys-Phe-NH2;His-Tyr-D-Arg-Trp-Lys-Phe-D-Asp-Ala-Arg-Cys-D-Tyr-His-Phe-D-Lys-Tyr-His-Ser-NH2; Lys-D-Arg-Tyr-NH2; Lys-D-Gln-Tyr-Arg-D-Phe-Trp-NH2; Lys-Dmt-D-Arg-NH2; Lys-D-Phe-Arg-Dmt-NH2; Lys-D-Phe-Arg-Tyr-NH2; Lys-Phe-NH2; Lys-Trp-D-Tyr-Arg-Asn-Phe-Tyr-D-His-NH2; Met-Tyr-D-Arg-Phe-Arg-NH2; Met-Tyr-D-Lys-Phe-Arg; Phe-Arg-D-His-Asp; Phe-D-Arg-2′
6′
-Dmt-Lys-NH2;Phe-D-Arg-D-Phe-Lys-NH2; Phe-D-Arg-His; Phe-D-Arg-Lys-Trp-Tyr-D-Arg-His; Phe-D-Arg-Phe-D-Lys-NH2; Phe-D-Arg-Phe-Lys-NH2; Phe-D-Dmt-Arg-Lys-NH2; Phe-D-Tyr-Arg-Lys-NH2; Phe-Lys-Dmt-NH2; Phe-Phe-D-Tyr-Arg-Glu-Asp-D-Lys-Arg-D-Arg-His-Phe-NH2; Phe-Tyr-Lys-D-Arg-Trp-His-D-Lys-D-Lys-Glu-Arg-D-Tyr-Thr; Thr-Gly-Tyr-Arg-D-His-Phe-Trp-D-His-Lys; Thr-Tyr-Arg-D-Lys-Trp-Tyr-Glu-Asp-D-Lys-D-Arg-His-Phe-D-Tyr-Gly-Val-Ile-D-His-Arg-Tyr-Lys-NH2; Trp-D-Lys-Tyr-Arg-NH2; Trp-Lys-Phe-D-Asp-Arg-Tyr-D-His-Lys; Tyr-Asp-D-Lys-Tyr-Phe-D-Lys-D-Arg-Phe-Pro-D-Tyr-His-Lys; Tyr-D-Arg-NH2; Tyr-D-Arg-Phe-Lys-Glu-NH2; Tyr-D-Arg-Phe-Lys-NH2; Tyr-D-His-Phe-D-Arg-Asp-Lys-D-Arg-His-Trp-D-His-Phe; Tyr-D-Phe-Arg-Lys-NH2; Tyr-His-D-Gly-Met; and Val-D-Lys-His-Tyr-D-Phe-Ser-Tyr-Arg-NH2, and further comprising one or more additional active agents selected from the group consisting of cyclosporine, a cardiac drug, an anti-inflammatory, an anti-hypertensive drug, an antibody, an ophthalmic drug, an antioxidant, a metal complexer, and an antihistamine. - View Dependent Claims (2, 3, 4, 5)
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Specification