Inspiratory synthesis of nitric oxide

• US 10,293,133 B2
• Filed: 03/14/2014
• Issued: 05/21/2019
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Zapol, Warren M., Yu, Binglan, Hardin, Paul, Hickcox, Matthew
• Primary Examiner(s): Tsai, Michael J
• Application Number:
  US14/777,072
• Publication Number:
  US 20160038710A1
• Time in Patent Office: 1,894 Days
• CPC Class Codes: A61M 15/02 with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
• CPC Class Codes: A61M 16/0003 Accessories therefor, e.g. sensors, vibrators, negative pressure
• CPC Class Codes: A61M 16/0057 Pumps therefor
• CPC Class Codes: A61M 16/0063 Compressors
• CPC Class Codes: A61M 16/0072 Tidal volume piston pumps
• CPC Class Codes: A61M 16/0465 Tracheostomy tubes; Devices for performing a tracheostomy; Accessories therefor, e.g. masks, filters
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 16/10 Preparation of respiratory gases or vapours
• CPC Class Codes: A61M 16/101 using an oxygen concentrator
• CPC Class Codes: A61M 16/107 in the inspiratory path
• CPC Class Codes: A61M 16/108 before being humidified or mixed with a beneficial agent
• CPC Class Codes: A61M 16/12 by mixing different gases
• CPC Class Codes: A61M 16/20 Valves specially adapted to medical respiratory devices
• CPC Class Codes: A61M 16/202 electrically actuated
• CPC Class Codes: A61M 16/209 Relief valves
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2016/0033 electrical
• CPC Class Codes: A61M 2016/1025 the O2 concentration
• CPC Class Codes: A61M 2016/1035 the anaesthetic agent concentration
• CPC Class Codes: A61M 2202/0208 Oxygen
• CPC Class Codes: A61M 2202/0216 : Ozone
• CPC Class Codes: A61M 2202/0275 : Nitric oxide [NO]
• CPC Class Codes: A61M 2205/04 : implanted
• CPC Class Codes: A61M 2205/33 : Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/3303 : Using a biosensor
• CPC Class Codes: A61M 2205/3334 : Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3553 : remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3561 : local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/3569 : sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/3584 : using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/3592 : using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/3606 : cooled
• CPC Class Codes: A61M 2205/366 : by liquid heat exchangers
• CPC Class Codes: A61M 2205/50 : with microprocessors or computers
• CPC Class Codes: A61M 2205/7545 : for solid matter, e.g. microaggregates
• CPC Class Codes: A61M 2210/1032 : Trachea
• CPC Class Codes: A61M 2230/40 : Respiratory characteristics
• CPC Class Codes: B01D 2251/304 : of sodium
• CPC Class Codes: B01D 2251/306 : of potassium
• CPC Class Codes: B01D 2251/404 : of calcium
• CPC Class Codes: B01D 53/56 : Nitrogen oxides B01D53/60 takes precedence
• CPC Class Codes: C01B 21/203 : Preparation of nitrogen oxides using a plasma or an electric discharge
• CPC Class Codes: Y02A 50/20 : Air quality improvement or preservation, e.g. vehicle emission control or emission reduction by using catalytic converters

Abstract

A system for generating nitric oxide can include an apparatus positioned in a trachea of a mammal, the apparatus including a respiration sensor for collecting information related to one or more triggering events associated with the trachea, an oxygen sensor for collecting information related to a concentration of oxygen in a gas, and one or more pairs of electrodes for initiating a series of electric arcs to generate nitric oxide, and the system for generating nitric oxide can also include a controller for determining one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor, wherein the series of electric arcs is initiated based on the control parameters determined by the controller.

Claims

1. A method comprising:

collecting information related to one or more triggering events associated with a respiratory system, the collected information comprising information from at least one oxygen sensor relating to a concentration of oxygen in a reactant gas;

determining one or more control parameters based on the collected information, the control parameters being determined by a controller in the form of a processor that is configured to be in communication with the at least one oxygen sensor and a spark chamber; and

initiating a series of electric arcs in the spark chamber to generate nitric oxide in the reactant gas to produce a product gas based on the determined control parameters.

2. The method of claim 1, wherein the triggering event is at least one of a reduction of temperature due to an inspiration of gas or a flow of gas.

3. The method of claim 1, wherein the information related to one or more triggering events includes one or more of an onset time of an inspiration, a tidal volume of an inspiration, a temperature of an inspired gas, and a concentration of oxygen in a reactant gas.

4. The method of claim 1, wherein the series of electric arcs is produced at one of when the triggering event occurs or a pre-defined amount of time before the triggering event occurs.

5. The method of claim 1, wherein a pulse train initiates the series of electric arcs, the pulse train including pulse groups having pulses with different pulse widths.

6. The method of claim 5, wherein the pulse width of initial pulses in one of the pulse groups is wider than other pulses in the pulse group.

7. The method of claim 5, wherein the series of electric arcs is configured to generate a reduced level of nitrogen dioxide or ozone.

8. The method of claim 7, wherein the reduced level of nitrogen dioxide has a concentration that is less than 20%, 10%, 6%, or 5% of a concentration of the generated nitric oxide.

9. The method of claim 1, wherein the respiratory system includes at least one of a tracheostomy tube, an endotracheal tube, or a patient wearable mask.

10. An apparatus comprising:

a respiration sensor for collecting information related to one or more triggering events associated with a respiratory system;

an oxygen sensor for collecting information related to a concentration of oxygen in a reactant gas;

a controller in the form of a processor in communication with the respiratory sensor, the oxygen sensor, and a spark chamber, the controller configured to determine one or more control parameters based on the collected information from the respiration sensor and the oxygen sensor; and

electrodes for initiating a series of electric arcs in the spark chamber to generate nitric oxide in the reactant gas to produce a product gas based on the determined control parameters communicated to the spark chamber from the controller.

11. The apparatus of claim 10, wherein the triggering event is at least one of a reduction of temperature due to an inspiration of gas, or a flow of gas past the respiration sensor.

12. The apparatus of claim 10, wherein the information related to one or more triggering events includes one or more of an onset time of an inspiration, a tidal volume of an inspiration, a temperature of an inspired gas, and a concentration of oxygen in a reactant gas.

13. The apparatus of claim 10, wherein the electrodes produce the series of electric arcs when at least one of the triggering event occurs or a pre-defined amount of time before the triggering event occurs.

14. The apparatus of claim 10, wherein a pulse train initiates the series of electric arcs, the pulse train including pulse groups having pulses with different pulse widths.

15. The apparatus of claim 14, wherein the pulse width of initial pulses in one of the pulse groups is wider than other pulses in the pulse group.

16. The apparatus of claim 14, wherein the series of electric arcs generates a reduced level of nitrogen dioxide or ozone.

17. The apparatus of claim 16, wherein the reduced level of nitrogen dioxide has a concentration that is less than 20%, 10%, 6%, or 5% of a concentration of the generated nitric oxide.

18. The apparatus of claim 10, wherein the respiratory system includes at least one of a trachea, a tracheostomy tube, an endothracheal tube, or a patient wearable mask.

19. The apparatus of claim 18, wherein the patient wearable mask includes one or more valves for separating an inspiratory gas flow from an expiratory gas flow.

20. The apparatus of claim 10, wherein the sensor or the electrodes are configured to be positioned in a trachea.

21. The apparatus of claim 10, wherein the electrodes comprise at least one of a noble metal, iridium or nickel.

22. A system for generating nitric oxide, the system comprising:

an apparatus positioned in a trachea of a mammal, the apparatus comprising;

a respiration sensor for collecting information related to one or more triggering events associated with the trachea;

an oxygen sensor for collecting information related to a concentration of oxygen in a reactant gas;

one or more pairs of electrodes in a spark chamber for initiating a series of electric arcs to generate nitric oxide in the reactant gas to produce a product gas; and

a controller in the form of a processor in communication with the respiration sensor, the oxygen sensor, and the spark chamber, the controller configured to determine one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor,

wherein the series of electric arcs is initiated based on the control parameters determined by the controller.

23. The system of claim 22, wherein the triggering event is at least one of a reduction of temperature due to an inspiration of gas or a flow of gas past the respiration sensor.

24. The system of claim 22, wherein the information related to one or more triggering events includes one or more of an onset time of an inspiration, a tidal volume of an inspiration, a temperature of an inspired gas, and a concentration of oxygen in a reactant gas.

25. The system of claim 22, wherein the electrodes produce the series of electric arcs at least one of when the triggering event occurs or a pre-defined amount of time before the triggering event occurs.

26. The system of claim 22, wherein a pulse train initiates the series of electric arcs, the pulse train including pulse groups having pulses with different pulse widths.

27. The system of claim 26, wherein the pulse width of initial pulses in one of the pulse groups is wider than other pulses in the pulse group.

28. The system of claim 26, wherein the series of electric arcs generates a reduced level of nitrogen dioxide or ozone.

29. The system of claim 28, wherein the reduced level of nitrogen dioxide has a concentration that is less than 20%, 10%, 6%, or 5% of a concentration of the generated nitric oxide.

30. The system of claim 22, wherein the electrodes comprise at least one of a noble metal, iridium, or nickel.

31. An apparatus implantable in the intercartilaginous rings in the neck, the apparatus comprising:

a respiration sensor for collecting information related to one or more triggering events associated with a respiratory system;

an oxygen sensor for collecting information related to a concentration of oxygen in a reactant gas;

a controller in the form of a processor in communication with the respiration sensor, the oxygen sensor, and a spark chamber, the controller configured to determine one or more control parameters based on the collected information from the respiration sensor and the oxygen sensor; and

one or more pairs of electrodes that reside inside the spark chamber, the electrodes for initiating a series of electric arcs to generate nitric oxide in the reactant gas to produce a product gas based on the determined control parameters communicated to the spark chamber from the controller, wherein the spark chamber is separated from an external environment by a membrane that is permeable to nitric oxide and impermeable to nitrogen dioxide and ozone.

32. The apparatus of claim 31, further comprising a sweeping device for removing mucus from the membrane.

33. An apparatus implantable in the trachea of a mammal using the Seldinger technique, the apparatus comprising:

a respiration sensor for collecting information related to one or more triggering events associated with a respiratory system;

an oxygen sensor for collecting information related to a concentration of oxygen in a reactant gas;

a controller in the form of a processor in communication with the respiration sensor, the oxygen sensor, and a spark chamber, the controller configured to determine for determining one or more control parameters based on the collected information from the respiration sensor and the oxygen sensor; and

one or more pairs of electrodes in the spark chamber for initiating a series of electric arcs to generate nitric oxide in the reactant gas to produce a product gas based on the determined control parameters communicated to the spark chamber from the controller.