Histotripsy excitation sequences optimized for bubble cloud formation using shock scattering
First Claim
1. A method of treating tissue with ultrasound energy, comprising the steps of:
- delivering a first pulse of a Histotripsy excitation sequence from an ultrasound therapy transducer, the first pulse comprising an initiation pressure waveform configured to produce at least one bubble in the tissue;
delivering a second pulse of the Histotripsy excitation sequence from the ultrasound therapy transducer, the second pulse comprising a scattering pressure waveform configured to interact with the at least one bubble within a life-cycle of the at least one bubble; and
producing cavitation nuclei near the at least one bubble with the scattering pressure waveform.
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Accused Products
Abstract
Methods and devices for producing cavitation in tissue are provided. In one embodiment, a shock scattering method of Histotripsy therapy comprises delivering an initiation pressure waveform from an ultrasound therapy transducer into tissue, the initiation pressure waveform being configured to produce at least one bubble in the tissue, delivering a scattering pressure waveform from the ultrasound therapy transducer into the at least one bubble within a life-cycle of the at least one bubble, and producing cavitation nuclei near the at least one bubble with the scattering pressure waveform. The scattering pressure waveform can be delivered during the life-cycle of the at least one bubble. In some embodiments, the scattering pressure waveform is delivered within 5 μs to 1 s of the initiation pressure waveform. Systems for performing shock scattering Histotripsy therapy are also discussed.
308 Citations
19 Claims
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1. A method of treating tissue with ultrasound energy, comprising the steps of:
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delivering a first pulse of a Histotripsy excitation sequence from an ultrasound therapy transducer, the first pulse comprising an initiation pressure waveform configured to produce at least one bubble in the tissue; delivering a second pulse of the Histotripsy excitation sequence from the ultrasound therapy transducer, the second pulse comprising a scattering pressure waveform configured to interact with the at least one bubble within a life-cycle of the at least one bubble; and producing cavitation nuclei near the at least one bubble with the scattering pressure waveform. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of treating tissue with ultrasound energy, comprising the steps of:
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transmitting a first pulse of a Histotripsy excitation sequence from an ultrasound therapy transducer, the first pulse comprising an initiation pressure waveform configured to produce at least one bubble in the tissue; during a life-cycle of the at least one bubble, transmitting a second pulse of the Histotripsy excitation sequence from the ultrasound therapy transducer, the second pulse comprising a scattering pressure waveform configured to interact with the at least one bubble, the scattering pressure waveform configured to become a shocked focal pressure waveform in the tissue having a shocked positive pressure half cycle and a shocked negative pressure half cycle, the shocked positive pressure half cycle being configured to impinge on the at least one bubble and to scatter, invert, and constructively interfere with the shocked negative pressure half cycle to form a negative pressure half cycle waveform; and producing cavitation nuclei near the at least one bubble with a shock scattering mechanism between the positive pressure half cycle waveform and the at least one bubble.
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15. A method of delivering ultrasound energy to tissue, comprising the steps of:
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delivering a first pulse of a Histotripsy excitation sequence from an ultrasound therapy transducer, the first pulse comprising an initiation pulse configured to provide at least 5 MPa of peak negative pressure to produce at least one bubble in the tissue; delivering a second pulse of the Histotripsy excitation sequence from the ultrasound therapy transducer, the second pulse comprising a first scattering pulse configured to interact with the at least one bubble within 5 μ
s to 200 μ
s of the initiation pulse; andproducing a cavitation cloud of nuclei near the at least one bubble with a shock scattering mechanism between the first scattering pulse and the at least one bubble.
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16. An ultrasound therapy system, comprising:
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an ultrasound therapy transducer; and an ultrasound therapy generator coupled to the ultrasound therapy transducer, the ultrasound therapy generator configured to drive the ultrasound therapy transducer to deliver a first pulse of a Histotripsy excitation sequence comprising an initiation pressure waveform into tissue to produce at least one bubble in tissue, the ultrasound therapy generator being further configured to drive the ultrasound therapy transducer to deliver a second pulse of the Histotripsy excitation sequence comprising a first scattering pressure waveform within 5 μ
s to 200 μ
s of the initiation pressure waveform into the at least one bubble to produce cavitation nuclei near the at least one bubble. - View Dependent Claims (17, 18, 19)
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Specification