Flexible manufacturing system
First Claim
Patent Images
1. A unitary structure adapted to be disposed within a housing, comprising:
- at least one controlled air, sealable, sterilizable cleanroom having an entry point and an exit point;
a cleanroom entry portion coupled to and selectively isolated from the cleanroom, the cleanroom entry portion for controlling personnel flow to the cleanroom via the entry point;
a cleanroom exit portion coupled to and selectively isolated from the cleanroom and separated from the cleanroom entry portion, the cleanroom exit portion for controlling personnel flow from the cleanroom via the exit point;
means for permitting movement of the cleanroom within the housing; and
a mechanical system room that, when connected to the cleanroom, is fixed relative to the cleanroom, the mechanical system room comprising;
at least two air handling units that provide air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to the cleanroom via one or more supply outlets, wherein a pressure differential is formed between the cleanroom and the exterior of the structure; and
at least two power supplies that provide power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external electrical power sources,wherein when one of the at least two air handling units breaks down, the other of the at least two air handling units provides air to the cleanroom without interruption, andwherein when one of the at least two power supplies breaks down, the other of the at least two power supplies provides power to the electrical outlets in the cleanroom without interruption.
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Accused Products
Abstract
A flexible, multi-product, multi-technology, expandable facility for manufacturing products, such as biologicals, pharmaceuticals, or chemicals, and manufacturing processes using elements of such a facility.
162 Citations
36 Claims
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1. A unitary structure adapted to be disposed within a housing, comprising:
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at least one controlled air, sealable, sterilizable cleanroom having an entry point and an exit point; a cleanroom entry portion coupled to and selectively isolated from the cleanroom, the cleanroom entry portion for controlling personnel flow to the cleanroom via the entry point; a cleanroom exit portion coupled to and selectively isolated from the cleanroom and separated from the cleanroom entry portion, the cleanroom exit portion for controlling personnel flow from the cleanroom via the exit point; means for permitting movement of the cleanroom within the housing; and a mechanical system room that, when connected to the cleanroom, is fixed relative to the cleanroom, the mechanical system room comprising; at least two air handling units that provide air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to the cleanroom via one or more supply outlets, wherein a pressure differential is formed between the cleanroom and the exterior of the structure; and at least two power supplies that provide power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external electrical power sources, wherein when one of the at least two air handling units breaks down, the other of the at least two air handling units provides air to the cleanroom without interruption, and wherein when one of the at least two power supplies breaks down, the other of the at least two power supplies provides power to the electrical outlets in the cleanroom without interruption. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A facility adapted to be disposed within a housing, comprising:
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at least one controlled air, sealable, sterilizable cleanroom having an entry point and an exit point; a cleanroom entry portion coupled to and selectively isolated from the cleanroom, the cleanroom entry portion for controlling personnel flow to the cleanroom via the entry point; a cleanroom exit portion coupled to and selectively isolated from the cleanroom and separated from the cleanroom entry portion, the cleanroom exit portion for controlling personnel flow from the cleanroom via the exit point; means for permitting movement of the cleanroom within the housing; a support room adjacent the cleanroom; a vertical wall separating the cleanroom and the support room; at least two air handling units in the support room that provide air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to the cleanroom via one or more supply outlets, wherein a pressure differential is formed between the cleanroom and the exterior of the structure; and at least two power supplies that provide power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external power sources, wherein when one of the at least two air handling units breaks down, the other of the at least two air handling units provides air to the cleanroom without interruption, wherein when one of the at least two power supplies breaks down, the other of the at least two power supplies provides power to the electrical outlets in the cleanroom without interruption. - View Dependent Claims (28, 29, 30, 31)
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32. A unit adapted to be disposed within a housing, comprising:
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at least one controlled air, sealable, sterilizable cleanroom having an entry point and an exit point; a cleanroom entry portion coupled to and selectively isolated from the cleanroom, the cleanroom entry portion for controlling personnel flow to the cleanroom via the entry point; a cleanroom exit portion coupled to and selectively isolated from the cleanroom and separated from the cleanroom entry portion, the cleanroom exit portion for controlling personnel flow from the cleanroom via the exit point; means for permitting movement of the cleanroom within the housing; a mechanical system room that, when connected to the cleanroom, is fixed relative to the cleanroom; and a vertical wall separating the cleanroom and the mechanical system room, wherein the mechanical system room comprises two or more redundant systems, the redundant systems comprising; at least two air handling units that provide air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to the clean room via one or more supply outlets, wherein a pressure differential is formed between the cleanroom and the exterior of the unit; and at least two power supplies that provide power to electrical outlets in the cleanroom, wherein the at least two power supplies are connectable to one or more external power sources, wherein when one of the at least two air handling units breaks down, the other of the at least two air handling units provides air to the cleanroom without interruption, and wherein when one of the at least two power supplies breaks down, the other of the at least two power supplies provides power to the electrical outlets in the cleanroom without interruption. - View Dependent Claims (33, 34, 35)
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36. A method of making a unitary unit adapted to be disposed within a housing, the method comprising:
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building at least one controlled air, sealable, sterilizable cleanroom, the cleanroom having an entry point and an exit point, and the cleanroom comprising means for permitting movement of the cleanroom within the housing; connecting a cleanroom entry portion to the cleanroom, the cleanroom entry portion selectively isolated from the cleanroom, the cleanroom entry portion for controlling personnel flow to the cleanroom via the entry point; connecting a cleanroom exit portion to the cleanroom, the cleanroom exit portion selectively isolated from the cleanroom and separated from the cleanroom entry portion, the cleanroom exit portion for controlling personnel flow from the cleanroom via the exit point; and connecting a mechanical system room to the cleanroom, wherein when the mechanical system room is connected to the cleanroom, the mechanical system room is fixed relative to the mechanical system room, the mechanical system room comprising; at least two air handling units that provide air to the cleanroom with at least Class 100,000 air purity, the air handling units connected to the cleanroom via one or more supply outlets, wherein a pressure differential is formed between the cleanroom and the exterior of the unit; and at least two power supplies that provide power to electrical outlets in the cleanroom from two sources, wherein the at least two power supplies are connectable to one or more external electrical power sources, wherein when one of the at least two air handling units breaks down, the other of the at least two air handling units provides air to the cleanroom without interruption, and wherein when one of the at least two power supplies breaks down, the other of the at least two power supplies provides power to the electrical outlets in the cleanroom without interruption.
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Specification