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Method, device, and system for diagnosing and monitoring frailty

  • US 10,299,736 B2
  • Filed: 03/27/2015
  • Issued: 05/28/2019
  • Est. Priority Date: 03/27/2014
  • Status: Active Grant
First Claim
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1. An ambulatory system to identify the presence and degree of frailty comprising:

  • a wearable sensor, configured to be attached to or worn by a person, the sensor configured to be attached to an upper body of a person, the sensor including at least an accelerometer configured to generate signals in response to motion or movements of the person, the accelerometer configured to measure at least a frontal acceleration pattern; and

    one or more processor circuits configured to receive and analyze one or more signals from the accelerometer as a result of spontaneous daily activity, the processor circuits configured to determine information about frailty status including at least a determination that assists in the classification of the person as non-frail, pre-frail, or frail, the one or more processor circuits performing at least the following steps;

    determining a score for one or more frailty related biomarkers selected from the group consisting of;

    flopping, cautious sitting, slowness, weakness, cognitive decline, cautious sit to walk, or exhaustion, the score determined based at least on the measured frontal acceleration pattern measured by the accelerometer, the score further determined based on identifying activities measured by the accelerometer as being dynamic or static;

    determining a score for one or more physiological responses to the identified dynamic or static activities, the responses selected from the group consisting of;

    heart rate, heart rate variability, respiration rate, or skin temperature, the determined score for one or more physiological responses to the identified dynamic or static activities based at least in part on abnormal physiological responses to the identified dynamic or static activities, andusing the determined score for the one or more frailty related biomarkers as determined by the one or more processor circuits analyzing the signals from the accelerometer and the determined score for the one or more physiological responses to calculate an overall score, and from the overall score classifying the person into one of a plurality of predetermined classifications, the predetermined classifications including at least non-frail, pre-frail, or frail, wherein the classifying provides an early identification of early markers of frailty to allow early intervention and rehabilitation as compared to non-ambulatory systems that do not use signals resulting from spontaneous daily activity.

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