Ocular delivery systems and methods
First Claim
1. A method for treating conditions of the eye using a device comprising a fluid assembly coupled to a linear gear via a linkage, a housing, a plunger, and an elongate member comprising a lumen, wherein the fluid assembly comprises a reservoir, and wherein the plunger comprises a lumen that fluidly connects the reservoir to the lumen of the elongate member, a proximal end that is located slidably within the reservoir, and a distal end that is fixedly attached to the linear gear, comprising:
- advancing the elongate member into Schlemm'"'"'s canal by moving the linear gear and the fluid assembly together relative to the housing, wherein the linkage maintains a fixed distance between the fluid assembly and linear gear during advancement of the elongate member; and
retracting the elongate member and simultaneously delivering a fluid composition out of a distal opening of the lumen by moving the linear gear relative to the linkage, the fluid assembly, and the housing to decrease a distance between the fluid assembly and the linear gear, such that the plunger moves proximally within the reservoir to increase the length of the plunger within the reservoir and displace fluid composition within the reservoir.
8 Assignments
0 Petitions
Accused Products
Abstract
Described here are systems and methods for accessing Schlemm'"'"'s canal and for delivering an ocular device, tool, or fluid composition therein. The ocular devices may maintain the patency of Schlemm'"'"'s canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Some systems described here may be configured to cut or tear the trabecular meshwork with the body of an elongate member located within Schlemm'"'"'s canal. Other tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.
320 Citations
26 Claims
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1. A method for treating conditions of the eye using a device comprising a fluid assembly coupled to a linear gear via a linkage, a housing, a plunger, and an elongate member comprising a lumen, wherein the fluid assembly comprises a reservoir, and wherein the plunger comprises a lumen that fluidly connects the reservoir to the lumen of the elongate member, a proximal end that is located slidably within the reservoir, and a distal end that is fixedly attached to the linear gear, comprising:
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advancing the elongate member into Schlemm'"'"'s canal by moving the linear gear and the fluid assembly together relative to the housing, wherein the linkage maintains a fixed distance between the fluid assembly and linear gear during advancement of the elongate member; and retracting the elongate member and simultaneously delivering a fluid composition out of a distal opening of the lumen by moving the linear gear relative to the linkage, the fluid assembly, and the housing to decrease a distance between the fluid assembly and the linear gear, such that the plunger moves proximally within the reservoir to increase the length of the plunger within the reservoir and displace fluid composition within the reservoir. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification