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Methods for delivering entanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device

  • US 10,300,010 B2
  • Filed: 11/16/2017
  • Issued: 05/28/2019
  • Est. Priority Date: 12/23/2010
  • Status: Active Grant
First Claim
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1. A method for delivering Etanercept to a patient, the method comprising:

  • providing a solid Etanercept dosage shaped as a tissue penetrating member having a pointed tip, the tissue penetrating member configured to be carried by a swallowable capsule and penetrate and be inserted into an intestinal wall, wherein upon ingestion, the capsule advances to the small intestine of the patient; and

    delivering the solid Etanercept dosage into the wall of the small intestine by an application of mechanical force upon a surface of the tissue penetrating member from an actuator operably coupled to the tissue penetrating member wherein upon insertion into the intestinal wall, the tissue penetrating member remains to release Etanercept into the blood stream from the intestinal wall by degradation of the of the tissue penetrating member.

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