Combination comprising N-acetyl-L-cysteine and its use

• US 10,300,038 B2
• Filed: 10/23/2017
• Issued: 05/28/2019
• Est. Priority Date: 04/01/2011
• Status: Active Grant

• Current Assignee: Iasomai AB (Pinsalus AB)
• Original Assignee: Iasomai AB (Pinsalus AB)
• Inventors: Parasassi, Tiziana, Costa, Graziella, Krasnowska, Ewa, Pittaluga, Eugenia
• Primary Examiner(s): Parad, Dennis J
• Application Number:
  US15/791,290
• Publication Number:
  US 20180036276A1
• Time in Patent Office: 582 Days
• Field of Search: None
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/28 Compounds containing heavy metals
• CPC Class Codes: A61K 31/4045 Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
• CPC Class Codes: A61K 31/573 substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 8/23 Sulfur; Selenium; Tellurium; Compounds thereof
• CPC Class Codes: A61K 8/447 containing sulfur
• CPC Class Codes: A61K 8/4913 having five membered rings, e.g. pyrrolidone carboxylic acid
• CPC Class Codes: A61K 8/58 containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
• CPC Class Codes: A61K 8/63 Steroids; Derivatives thereof
• CPC Class Codes: A61L 29/08 Materials for coatings
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 15/08 for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 17/14 for baldness or alopecia
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 31/00 : Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/04 : Antibacterial agents
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: A61P 37/06 : Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 39/02 : Antidotes
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/00 : Drugs for disorders of the endocrine system
• CPC Class Codes: A61P 5/24 : of the sex hormones
• CPC Class Codes: A61Q 19/08 : Anti-ageing preparations
• CPC Class Codes: Y02A 50/30 : Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin, and a medical product or pharmaceutical composition comprising such combination, useful for the treatment of a variety of diseases and conditions is described. The combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin is also useful for cosmetic treatment of skin and as an antibacterial agent.

Claims

1. A medical product consisting of one or more excipients and active agents consisting of:

(i) N-acetyl-L-cysteine;

(ii) selenium in the form of selenomethionine; and

(iii) melatonin

and/or physiologically acceptable salts thereof.

2. The medical product of claim 1, wherein components (i)-(iii) are provided as separate dosage units.

3. The medical product of claim 1, wherein N-acetyl-L-cysteine is present at a concentration of 3-10 wt. %, selenomethionine is present at a concentration of 0.3-1 wt. %, and melatonin is present at a concentration of 0.01-0.2 wt. %.

4. The medical product of claim 3, wherein N-acetyl-L-cysteine is present at a concentration of 5 wt. %, selenomethionine is present at a concentration of 0.5 wt. %, and melatonin is present at a concentration of 0.1 wt. %.

5. A medical device comprising the medical product of claim 1.

6. The medical device of claim 5, wherein the medical product is incorporated into a plastic material of the medical device.

7. A hydrogel coating comprising the medical product of claim 1.

8. A medical device comprising the hydrogel coating of claim 7.

9. The medical device of claim 8, wherein the hydrogel coating is incorporated into a plastic material of the medical device.

10. A cosmetic product comprising the medical product of claim 1.

11. An antibacterial agent comprising the medical product of claim 1.

12. A dermatological product consisting of one or more dermatologically acceptable excipients and active agents consisting of:

(i) N-acetyl-L-cysteine;

(ii) selenium in the form of selenomethionine; and

(iii) melatonin

and/or physiologically acceptable salts thereof.

13. The dermatological product of claim 12, wherein components (i)-(iii) are provided as separate dosage units.

14. The dermatological product of claim 12, wherein N-acetyl-L-cysteine is present at a concentration of 3-10 wt. %, selenomethionine is present at a concentration of 0.3-1 wt. %, and melatonin is present at a concentration of 0.01-0.2 wt. %.

15. The dermatological product of claim 14, wherein N-acetyl-L-cysteine is present at a concentration of 5 wt. %, selenomethionine is present at a concentration of 0.5 wt. %, and melatonin is present at a concentration of 0.1 wt. %.

16. The dermatological product of claim 12, wherein the one or more dermatologically acceptable excipients comprise water, ceteareth 25 glyceryl stearate, tea stearate, cetearyl alcohol, caprylic/capric triglyceride, dimethicone, glyceryn hydrogenated polyisobutene, polysorbate 60, pentylene glycol, or vanilla.

17. A medical product consisting of one or more excipients and active agents consisting of:

(i) N-acetyl-L-cysteine;

(ii) selenium in the form of selenomethionine;

(iii) melatonin; and

(iv) dexamethasone

and/or physiologically acceptable salts thereof.

18. The medical product of claim 17, wherein components (i)-(iii) are provided as separate dosage units.

19. A hydrogel coating comprising the medical product of claim 17.

20. A medical device comprising the medical product of claim 17.