Capsule phototherapy

• US 10,300,296 B2
• Filed: 03/07/2012
• Issued: 05/28/2019
• Est. Priority Date: 03/17/2010
• Status: Active Grant

• Current Assignee: PhotoPill Medical Ltd.
• Original Assignee: PhotoPill Medical Ltd.
• Inventors: Ben-Yehuda, Sharon, Ben-Yehuda, Ram
• Primary Examiner(s): Downey, John R
• Application Number:
  US14/004,691
• Publication Number:
  US 20140005758A1
• Time in Patent Office: 2,638 Days
• Field of Search: 607 88- 92
• CPC Class Codes: A61N 2005/0609 Stomach and/or esophagus
• CPC Class Codes: A61N 2005/0643 Applicators, probes irradiating specific body areas in close proximity
• CPC Class Codes: A61N 2005/0645 Applicators worn by the patient
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 2005/0662 Visible light
• CPC Class Codes: A61N 5/0603 for treatment of body cavities
• CPC Class Codes: A61N 5/0613 Apparatus adapted for a specific treatment
• CPC Class Codes: A61N 5/0624 for eliminating microbes, germs, bacteria on or in the body

Abstract

A swallowable capsule for providing phototherapy to a patient'"'"'s gastrointestinal (GI) tract, the capsule including a power supply, one or more phototherapeutic light sources, a speed determination unit for calculating speed of movement of the capsule in the GI tract, and a controller unit for activating one or more of the one or more light sources for delivering a therapeutic illumination dose to a target site in the GI tract, based, at least in part, on a determined speed. Related apparatus and methods are also described.

Claims

1. A programmable system for providing phototherapy to a patient'"'"'s gastrointestinal (GI) tract, said system comprises at least one swallowable capsule, said capsule comprising:

a power supply;

at least one phototherapeutic light source configured to emit light at at least one wavelength in a range selected from a group consisting of visible light, Near Infra Red (NIR) light and any combination thereof;

a speed determination unit for determining speed of movement of the capsule at at least one target site in the GI tract;

a controller unit for controlling illumination by said at least one phototherapeutic light source to provide an effective phototherapeutic illumination dose in a range of 0.1-1.0 Joules/cm² and for activating at least one of the at least one phototherapeutic light source for delivering said effective phototherapeutic illumination dose to said at least one target site, and

at least one processor controlling instructions for said controller unit operation;

wherein said processor is programmed to instruct said controller to calculate distance travelled along the GI tract, according to measured said speed of movement, and to turn ON said light source at at least one target site according to said distance travelled, said effective illumination dose is calculated by said processor according to the following formula;

Required Power=C*Dose/Intestine Speed, in which

C is a constant programmed in the controller;

Dose is a constant programmed in the controller; and

Intestine Speed is the speed of movement of the capsule in the GI tract.

2. The capsule according to claim 1, wherein, if the speed determination unit determines a capsule speed which is zero, the controller unit is configured to cause the controller unit to turn said at least one phototherapeutic light source OFF.

3. The capsule according to claim 1, wherein intensity of at least one of said at least one phototherapeutic light source is adjustable based, at least in part, on said determined speed of movement of the capsule at said at least one target site in the GI tract.

4. The capsule according to claim 1, wherein said at least one phototherapeutic light source emits light at a wavelength in a range selected from a group consisting of 610-750, 800-950 nm and any combination thereof.

5. The capsule according to claim 1, wherein said at least one phototherapeutic light source emits light centered at a wavelength selected from a group consisting of 660 nm, 850 nm and any combination thereof.

17. The capsule according to claim 1, wherein said at least one region of said GI tract is identifiable from a member of a group consisting of:

a distance traveled along said GI tract;

a change in speed of movement of the capsule;

a change in pH of the environment of the capsule, an average speed of movement of said capsule, a distance from said capsule to a wall of said GI tract and any combination thereof.

19. The system of claim 1, wherein said power supply is a battery, said battery is located within said capsule.

20. The system of claim 1, wherein said capsule speed is determined by a motion detecting means.

21. The claim motion means of claim 20, wherein said motion means is selected from a group consisting of an accelerometer, or an optical motion sensing system.

22. The system of claim 1, wherein said system comprises a plurality of said capsules, wherein each of said capsules is programmed with different controlling instructions.

23. The system of claim 1, wherein said at least one GI target of at least one capsule is pre-programmed according to at least one diseased GI region of said patient.

24. The system of claim 1, said system comprises a plurality of said capsules, wherein each of said capsules is programmed with a different delay time, a different exposure time or a different location;

said plurality of capsules configured to provide phototherapy to at least one target sites of a patient'"'"'s GI tract while maintaining relatively low power consumption for each of said capsule.

6. A method for providing phototherapy to a portion of a GI tract comprising:

swallowing at least one capsule, said capsule comprising;

at least one phototherapeutic light source configured to emit light at at least one wavelength in a range selected from a group consisting of visible light, Near Infra Red (NIR) light and any combination thereof;

a speed determination unit for calculating speed of movement of the capsule in the GI tract,

a controller unit for controlling illumination by at least one of said at least one phototherapeutic light source so as to provide an effective phototherapeutic illumination dose to be in a range of 0.1-1.0 Joules/cm² and for activating at least one of the at least one phototherapeutic light source for delivering said effective phototherapeutic illumination dose to said at least one target site, and

at least one processor controlling instructions for said controller unit operation;

wherein said processor is programmed to instruct said controller to calculate distance travelled along the GI tract, according to measured said speed of movement, and to turn ON said light source at at least pre-defined target area according to said distance travelled, said effective illumination dose is calculated by said processor according to the following formula;

Required Power=C*Dose/Intestine Speed, in which

C is a constant programmed in the controller;

Dose is a constant programmed in the controller; and

Intestine Speed is the speed of movement of the capsule in the GI tract.

7. The method according to claim 6, wherein the effective phototherapeutic illumination dose is in a range of 0.25-0.5 Joule/cm².

8. The method according to claim 6, wherein said at least one phototherapeutic light source is turned off when the capsule computes a speed of the capsule which indicates that the capsule has stopped.

9. The method according to claim 6, wherein said at least one phototherapeutic light source emits light at a wavelength in a range selected from a group consisting of 610-750 nm, 800-950 nm and any combination thereof.

10. The method according to claim 6, wherein said at least one phototherapeutic light source emits light centered at a wavelength selected from a group consisting of 660 nm, 850 nm and any combination thereof.

11. The method according to claim 6, wherein the intraluminal phototherapy of the gastrointestinal (GI) tract is administered at a schedule selected from a group consisting of:

every other day;

three times a week, and ranging from once a day to once a week.

12. The method according to claim 6, wherein the intraluminal phototherapy of the gastrointestinal (GI) tract is administered a plurality of times.

13. The method according to claim 6, wherein the intraluminal phototherapy of the gastrointestinal (GI) tract is administered three times or more.

14. The method according to claim 6, wherein the method is used to treat inflammatory bowel disease selected from a group consisting of Crohn'"'"'s disease;

ulcerative colitis; and

indeterminate colitis.

15. The method according to claim 6, wherein the method is used to promote healing of the intestinal mucosa and submucosal tissues.

16. The method according to claim 6, additionally comprising a step of controlling activation of said at least one phototherapeutic light source when the capsule is in proximity to at least one of said at least one target site in the gastrointestinal (GI) tract so as to provide said effective phototherapeutic illumination dose to said at least one of said at least one target site of the GI tract, based, at least in part, on a determined speed of movement of the capsule at said at least one of said at least one target site of the GI tract.

18. The method according to claim 6, additionally comprising a step of identifying said at least one region of said GI tract from a member of a group consisting of:

a distance traveled along said GI tract;

a change in speed of movement of the capsule;

a change in pH of the environment of the capsule, an average speed of movement of said capsule, a distance from said capsule to a wall of said GI tract and any combination thereof.