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Polymorphs

  • US 10,301,313 B2
  • Filed: 10/05/2017
  • Issued: 05/28/2019
  • Est. Priority Date: 05/04/2006
  • Status: Active Grant
First Claim
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1. A method of preparing anhydrous polymorph D of the compound 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine, characterized in that it melts at 150±



  • C., the method comprising heating polymorph C of the compound 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine at a temperature of 100°

    C. to lose water, wherein polymorph C is characterized in that it loses water at a temperature of 30-100°

    C. and exhibits further thermal effects at a temperature of about 150°

    C. and about 175°

    C. in a differential scanning calorimetry (DSC) analysis.

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