Boron-containing small molecules as antiprotozoal agents

• US 10,301,329 B2
• Filed: 08/03/2016
• Issued: 05/28/2019
• Est. Priority Date: 08/14/2009
• Status: Active Grant

• Current Assignee: Anacor Pharmaceuticals, Inc. (Pfizer Inc.)
• Original Assignee: Anacor Pharmaceuticals, Inc. (Pfizer Inc.)
• Inventors: Chen, Daitao, Orr, Matthew, Sligar, Jessica, Jacobs, Robert, Plattner, Jacob J.
• Primary Examiner(s): Royds Draper, Leslie A.
• Application Number:
  US15/227,112
• Publication Number:
  US 20160340369A1
• Time in Patent Office: 1,028 Days
• Field of Search: None
• CPC Class Codes: A01N 55/08 containing boron
• CPC Class Codes: A61K 31/69 Boron compounds
• CPC Class Codes: A61P 33/02 Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
• CPC Class Codes: C07F 5/025 Boronic and borinic acid compounds
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.

Claims

1. A method of killing and/or preventing the growth of Trypanosoma brucei brucei, comprising:

contacting the Trypanosoma brucei brucei with an effective amount of a compound having a structure according to the following formula;