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Antibodies to IL-15

  • US 10,301,384 B2
  • Filed: 07/01/2015
  • Issued: 05/28/2019
  • Est. Priority Date: 07/02/2014
  • Status: Active Grant
First Claim
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1. An isolated antibody binding IL-15 comprising:

  • a) a heavy chain variable region comprising SEQ ID NO;

    5 or any variant thereof wherein 1, 2, 3, 4, 5 or 6 amino acids selected from arginine (R) at position H3 (VH RH3), methionine (M) at position H5 (VH MH5), alanine (A) at position H6 (VH AH6), alanine (A) at position H49 (VH AH49), aspartic acid (D) at position H61 (VH DH61), serine (S) at position H62 (VH SH62), methionine (M) at position H98 (VH MH98), tryptophan (W) at position H100C (VH WH100C), and methionine (M) at position H100E (VH MH100E) are substituted by a different amino acid, andb) a light chain variable region comprising SEQ ID NO;

    24 or any variant thereof wherein 1, 2, 3, or 4 amino acids selected from tyrosine (Y) at position L36 (VL YL36), leucine (L) at position L46 (VL LL46), aspartic acid (D) at position L91 (VL DL91) and serine (S) at position L92 (VL SL92) are substituted by a different amino acid,or an antigen-binding fragment thereof.

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