Device for adjusting the intraocular pressure

• US 10,307,292 B2
• Filed: 07/18/2012
• Issued: 06/04/2019
• Est. Priority Date: 07/18/2011
• Status: Active Grant

• Current Assignee: Mor Research Applications Ltd. (Clalit Health Services)
• Original Assignee: Mor Research Applications Ltd. (Clalit Health Services)
• Inventors: Litvin, Gilad
• Primary Examiner(s): Zimbouski, Ariana
• Application Number:
  US14/233,614
• Publication Number:
  US 20140148752A1
• Time in Patent Office: 2,512 Days
• CPC Class Codes: A61F 13/15252 compostable or biodegradable
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61L 31/04 Macromolecular materials
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 27/002 Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202

Abstract

Provided is a device for use in controlling the liquid outflow from the anterior chamber of the eye, methods of draining aqueous humor from the anterior chamber to the intra-orbital space using the device, methods for controlling the liquid outflow from the anterior chamber of the eye and further surgical methods for implanting the presently described device.

Claims

1. An implantable device for controlling liquid outflow from an anterior chamber of an eye, comprising:

an implantable elongate body having a first end that is positionable at an anterior chamber of the eye and a second end that is positionable at a conal orbital space of the eye,

wherein the elongate body is positionable on the sclera of the eye and is configured to provide a fluid path for draining fluid entering the first end of the elongate body from the anterior chamber to the conal orbital space via the second end,

wherein the elongate body comprises at least one first porous swellable polymeric fibrous material and at least one external tubular structure, the at least one first porous swellable fibrous polymeric material being disposed within the at least one external tubular structure.

2. The device according to claim 1, wherein said first porous swellable polymeric fibrous material is non-woven.

3. The device according to claim 1, wherein said first porous swellable polymeric fibrous material is electrospun.

4. The device according to claim 1, having an external at least one layer including at least one second polymeric fibrous material.

5. The device according to claim 1, having an external at least one layer including at least one second polymeric fibrous material wherein said at least one second polymeric fibrous material is a biostable and/or a biocompatible polymer.

6. The device according to claim 1, having an external at least one layer including at least one second polymeric fibrous material wherein said external at least one layer is made of a biodegradable polymer.

7. The device according to claim 1, having an external at least one layer including at least one second polymeric fibrous material wherein said external layer has an elongated shape exceeding the length of said first porous swellable polymeric fibrous material.

8. The device according to claim 1, wherein said first porous swellable polymer fibrous material comprises a water-swellable polymer fibrous material.

9. The device according to claim 1, wherein said first porous swellable polymeric fibrous material is non-woven and has a swellability of at least 50 percent in volume.

10. The device according to claim 1, wherein said first porous swellable polymeric fibrous material is non-woven and has an elasticity of at least 10 percent.

11. The device according to claim 1, wherein said first porous swellable polymeric fibrous material has a porosity of at least 50 percent.

12. The device according to claim 1, wherein said first porous swellable polymeric fibrous material has a water permeability of at least 0.3 ml/cm²/min.

13. The device according to claim 1, comprising at least two first porous swellable polymeric fibrous materials arranged in a layered structure.

14. The device according to claim 1, further comprising at least one pharmaceutical agent incorporated in said first porous swellable polymeric fibrous material.

15. The device according to claim 14, wherein said at least one pharmaceutical agent comprises an antifibrotic agent, an anticoagulant, an antithrombotic agent, an antibiotic agent, an anti-inflammatory agent, a biodegradable material, a pressure lowering agent, an antiangiogenic agent or any combination thereof.

16. A method for controlling the liquid outflow from the anterior chamber of the eye comprising:

providing a device according to claim 1; and

implanting said device into the eye of a subject so that at least one end of said device is directed towards (or located at) the anterior chamber and its opposite end is directed towards (or located at) the orbital space.

17. The implantable device of claim 1, wherein the first porous swellable polymeric fibrous material comprises pores which increase in volume responsive to an increase of intraocular pressure of fluid at the anterior chamber of the eye for adjusting intraocular pressure in the eye.

18. An implantable device for controlling liquid outflow from an anterior chamber of an eye, comprising:

an implantable elongate body having a first end that is positionable at an anterior chamber of an eye and a second end that is positionable at a conal orbital space of the eye, wherein the elongate body is positionable on the sclera of the eye and is configured to provide a fluid path for draining fluid entering the first end of the elongate body from the anterior chamber to the conal orbital space via the second end, wherein the elongate body comprises at least one first porous swellable polymeric fibrous material and at least one external tubular structure.

19. An implantable device for controlling and maintaining the dynamic equilibrium of aqueous production and liquid outflow from an anterior chamber of an eye, comprising:

an implantable elongate body having a first end that is positionable at an anterior chamber of an eye and a second end that is positionable at a conal orbital space of the eye, wherein the elongate body is positionable on the sclera of the eye and is configured to provide a fluid path for draining fluid entering the first end of the elongate body from the anterior chamber to the conal orbital space via the second end, wherein the elongate body comprises at least one first porous swellable polymeric fibrous material and at least one external tubular structure.