Multivalent and multispecific DR5-binding fusion proteins
First Claim
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1. An isolated polypeptide that binds death receptor 5 (DR5) and comprises a plurality of DR5 binding domains (DR5BDs), wherein each DR5BD is a VHH comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 128, a CDR2 comprising the amino acid sequence of SEQ ID NO;
131, and a CDR3 comprising the amino acid sequence of SEQ ID NO;
130, and wherein adjacent DR5BDs are operably linked by an amino acid linker.
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Abstract
The disclosure relates generally to molecules that specifically engage death receptor 5 (DR5), a member of the TNF receptor superfamily (TNFRSF). More specifically the disclosure relates to multivalent and multispecific molecules that bind at least DR5.
23 Citations
24 Claims
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1. An isolated polypeptide that binds death receptor 5 (DR5) and comprises a plurality of DR5 binding domains (DR5BDs), wherein each DR5BD is a VHH comprising a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 128, a CDR2 comprising the amino acid sequence of SEQ ID NO;
131, and a CDR3 comprising the amino acid sequence of SEQ ID NO;
130, and wherein adjacent DR5BDs are operably linked by an amino acid linker. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
- 128, a CDR2 comprising the amino acid sequence of SEQ ID NO;
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24. An isolated polypeptide that binds death receptor 5 (DR5), wherein the polypeptide is a homodimer of the amino acid sequence of SEQ ID NO:
- 113 fused to an Fc region polypeptide of SEQ ID NO;
2.
- 113 fused to an Fc region polypeptide of SEQ ID NO;
Specification