Practical ion mobility spectrometer apparatus and methods for chemical and/or biological detection

• US 10,309,929 B2
• Filed: 08/04/2018
• Issued: 06/04/2019
• Est. Priority Date: 02/14/2006
• Status: Active Grant

• Current Assignee: Excellims Corporation
• Original Assignee: Excellims Corporation
• Inventors: Wu, Ching
• Primary Examiner(s): Stoffa, Wyatt A
• Application Number:
  US16/055,038
• Publication Number:
  US 20180372684A1
• Time in Patent Office: 304 Days
• CPC Class Codes: G01N 27/622 Ion mobility spectrometry
• CPC Class Codes: H01J 49/0031 Step by step routines describing the use of the apparatus H01J49/0081 takes precedence
• CPC Class Codes: H01J 49/004 Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
• CPC Class Codes: H01J 49/0468 with means for heating or cooling the sample
• CPC Class Codes: H01J 49/062 Ion guides linear ion traps performing mass selection H01J49/4225, mass filters H01J49/421

Abstract

The present invention relates to drift tubes for ion mobility spectrometers. In one embodiment, the drift tube of the present invention uses a simplified design having helical resistive material to form substantially constant electric fields that guide ion movements. The drift tube for ion mobility spectrometers described herein is constructed with a non-conductive structure. This configuration provides a robust ion mobility spectrometer that is simple to build. One feature of the present invention is that the drift tube design described herein enables the ion mobility spectrometer to be built with a lower weight, lower power consumption, lower manufacturing cost, and free of sealants.

Claims

1. A drift tube for an ion mobility spectrometer comprising:

a) at least one dielectric structure component of the drift tube; and

b) at least one ion guide electrode that is affixed on the dielectric structure or structures, wherein the ion guide electrode or electrodes are arranged in a helical shape around a drift axis of the drift tube, or a serpentine shape.

2. The drift tube of claim 1, wherein the dielectric structure is made of aluminum nitride, beryllium oxide, fused silica, quartz, or alumina, having a shape of a flat plate, a curved plate, a round tube, a half round tube, a square tube, or a rectangular tube.

3. The drift tube of claim 1, wherein the dielectric structure has at least one substantially flat substrate.

4. The drift tube of claim 1, further comprises at least one electrical conductive leading contact in connection with the ion guiding electrodes.

5. The drift tube of claim 1, further comprises at least one heating element.

6. The drift tube of claim 5, wherein the heating element is mounted and/or affixed to the dielectric structure.

7. The drift tube of claim 5, wherein the heating element is located on the other side of the dielectric material from the ion guide electrodes.

8. The drift tube of claim 5, wherein the heating element is adjacent to the dielectric structure and in contact with the dielectric structure.

9. The drift tube of claim 1, wherein the ion guide electrode is made of conductive or resistive material.

10. The drift tube of claim 9, wherein the ion guide electrode is made of conductive material and is affixed on a cylindrical shape dielectric structure.

11. The drift tube of claim 9, wherein the ion guide electrode is made of resistive material and is affixed on a cylindrical shape dielectric structure.

12. The drift tube of claim 11, wherein the ion guide electrode has a helical shape.

13. The drift tube of claim 11, wherein the ion guide electrode has a serpentine shape.

14. The drift tube of claim 9, wherein the ion guide electrode is made of resistive material and is affixed on a flat dielectric structure.

15. The drift tube of claim 14, wherein the ion guide electrode has a serpentine pattern.

16. The drift tube of claim 9, wherein the resistivity of the resistive material is optimized to generate the desired electric field strength that guides ions.

17. The drift tube of claim 9, wherein the resistive material of the electrode is the same or different for a reaction region and a drift region of the drift tube.

18. The drift tube of claim 3, wherein the flat substrate has at least one electrode that has a serpentine pattern.

19. The drift tube of claim 1, wherein the ion guide electrode functions as an electric field barrier to guard a drift region and/or a reaction region of the drift tube.

20. The drift tube of claim 1, wherein the pitch of the electrode is optimized to shield a drift region and/or a reaction region of the drift tube from outside electric fields;

where the pitch in the reaction region is the same or different from the pitch in the drift region.