×

Genetically modified major histocompatibility complex mice

  • US 10,314,296 B2
  • Filed: 12/12/2017
  • Issued: 06/11/2019
  • Est. Priority Date: 02/22/2013
  • Status: Active Grant
First Claim
Patent Images

1. A genetically modified mouse whose genome comprises at an endogenous MHC locus:

  • a first nucleotide sequence encoding a chimeric human/mouse MHC I polypeptide that comprises α

    1, α

    2 and α

    3 domains of a human MHC I polypeptide operably linked to transmembrane and cytoplasmic domains of a mouse MHC I polypeptide,a second nucleotide sequence encoding a chimeric human/mouse MHC II α

    polypeptide that comprises α

    1 and α

    2 domains of a human MHC II α

    polypeptide operably linked to transmembrane and cytoplasmic domains of a mouse MHC II α

    polypeptide, anda third nucleotide sequence encoding a chimeric human/mouse MHC II β

    polypeptide that comprises β

    1 and β

    2 domains of a human MHC II β

    polypeptide operably linked to transmembrane and cytoplasmic domains of a mouse MHC II β

    polypeptide,wherein the mouse expresses the chimeric human/mouse MHC I, MHC II α and

    MHC II β

    polypeptides from the endogenous MHC locus, andwherein all genes encoding classical endogenous mouse MHC I and MHC II proteins that are expressed on a cell surface are functionally inactivated.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×