Subject holding unit and photoacoustic apparatus

• US 10,314,495 B2
• Filed: 05/05/2017
• Issued: 06/11/2019
• Est. Priority Date: 12/11/2009
• Status: Active Grant

• Current Assignee: Canon Kabushiki Kaisha (Canon Inc.)
• Original Assignee: Canon Kabushiki Kaisha (Canon Inc.)
• Inventors: Sudo, Yoshiaki, Sato, Akira
• Primary Examiner(s): Saint Surin, Jacques M
• Application Number:
  US15/588,319
• Publication Number:
  US 20170238810A1
• Time in Patent Office: 767 Days
• Field of Search: 73643
• CPC Class Codes: A61B 2560/0233 Optical standards
• CPC Class Codes: A61B 2576/00 Medical imaging apparatus involving image processing or analysis A61B1/00009, A61B6/52 and A61B8/52 take precedence; image processing per se G06T; details of algorithms for analysing medical images G06T7/0012
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence

Abstract

Provided is a photoacoustic apparatus capable of recognizing variation in reception characteristic among a plurality of receiving elements that detect an acoustic wave in the photoacoustic apparatus, with a simple configuration unique to the photoacoustic apparatus.

A photoacoustic apparatus includes a detecting unit including a plurality of receiving elements configured to detect an acoustic wave that is generated when an analyte is irradiated with light; a signal processing unit configured to acquire information about the inside of the analyte from a detected signal acquired from the detecting unit; an optical absorber configured to absorb the irradiation light; and a reception characteristic calculation unit configured to calculate reception characteristic information of the plurality of receiving elements on the basis of detected signals when the plurality of receiving elements receive an acoustic wave that is generated from the optical absorber.

Claims

1. A subject holding unit for a photoacoustic measuring apparatus comprising:

a holding member configured to hold a subject; and

an optical absorber located in or on the holding member, wherein the optical absorber has a substantially spherical shape and a size determined based on a frequency band to be measured and associated with a size of the subject,

wherein the optical absorber has a certain diameter D configured to meet the following conditions (1) to (3);

D_min≤

D≤

_max 

 

(1),

Fc_max=0.66c/D_min 

 

(2), and

Fc_min=0.66c/D_max 

 

(3),

where D, D_min, D_max represent a diameter of the optical absorber, its minimum value, and its maximum value, respectively;

c represents a sound speed in the subject;

Fc_min and Fc_max represent a minimum value and a maximum value of a peak frequency of an N-type waveform generated in the subject, respectively.

2. The subject holding unit according to claim 1, wherein the optical absorber has a certain optical absorption characteristic to be adapted for a calibration of a sensitivity of a transducer provided in an acoustic probe.

3. The subject holding unit according to claim 1, wherein the sound speed c in the subject satisfies the following condition (4):

1×

10⁶=0.66c/1×

10<sup>−

3</sup> 

 

(4)

4. The subject holding unit according to claim 1, wherein the size of the optical absorber is associated with a variation of a size of a tumor or a diameter of a blood vessel in a living body.

5. The subject holding unit according to claim 1, wherein the size of the optical absorber is no less than 1 mm and no more than 20 mm.

6. The subject holding unit according to claim 1, wherein the optical absorber has a higher optical absorbance than an optical absorbance of the holding member.

7. The subject holding unit according to claim 1, wherein the holding plate has a higher optical transparency than an optical transparency of the optical absorber.

8. The subject holding unit according to claim 1, wherein the optical absorber is secured to the holding member.

9. The subject holding unit according to claim 1, wherein a plurality of the optical absorbers are arranged with a spacing in or on the holding member.

10. The subject holding unit according to claim 1, wherein the plurality of the optical absorber are located discretely in association with an arrangement of transducer array in an acoustic probe.

11. A photoacoustic apparatus comprising:

the subject holding unit according to claim 1;

a light irradiation portion optically coupled to a light source; and

an acoustic probe configured to be acoustically coupled to the subject holding unit.

12. The photoacoustic apparatus according to claim 11, further comprising a moving unit configured to move the acoustic probe with respect to the subject holding unit.

13. The photoacoustic apparatus according to claim 12, wherein the moving unit is configured to move the light irradiation portion in association with a movement of the acoustic probe.

14. A subject holding unit for a photoacoustic measuring apparatus comprising:

a holding member configured to hold a subject; and

an optical absorber located in or on the holding member, wherein the optical absorber has a substantially spherical shape and a size determined based on a frequency band to be measured and associated with a size of the subject,

wherein the optical absorber has a diameter D configured to satisfy the conditions (1), (5), and (6);

D_min≤

D≤

D_max 

 

(1)

f_max=0.66c/D_min 

 

2), and

f_min=0.66c/D_max 

 

(3),

where D, D_min, and D_max represent a diameter of the optical absorber, its minimum value, and its maximum value, respectively;

c represents a sound speed in the subject;

f_min and f_max represent a minimum value and a maximum value of a frequency band to be measured, respectively.

15. The subject holding unit according to claim 14, wherein the sound speed c in the subject satisfies the following condition (4):

1×

10⁶=0.66c/1×

10<sup>−

3</sup> 

 

(4)

16. The subject holding unit according to claim 14, wherein the optical absorber has a certain optical absorption characteristic to be adapted for a calibration of a sensitivity of a transducer provided in an acoustic probe.

17. The subject holding unit according to claim 14, wherein the size of the optical absorber is associated with a variation of a size of a tumor or a diameter of a blood vessel in a living body.

18. The subject holding unit according to claim 14, wherein the size of the optical absorber is no less than 1 mm and no more than 20 mm.

19. The subject holding unit according to claim 14, wherein the optical absorber has a higher optical absorbance than an optical absorbance of the holding member.

20. The subject holding unit according to claim 14, wherein the holding plate has a higher optical transparency than an optical transparency of the optical absorber.

21. The subject holding unit according to claim 14, wherein the optical absorber is secured to the holding member.

22. The subject holding unit according to claim 14, wherein a plurality of the optical absorbers are arranged with a spacing in or on the holding member.

23. The subject holding unit according to claim 14, wherein the plurality of the optical absorber are located discretely in association with an arrangement of transducer array in an acoustic probe.

24. A photoacoustic apparatus comprising:

the subject holding unit according to claim 14;

a light irradiation portion optically coupled to a light source; and

an acoustic probe configured to be acoustically coupled to the subject holding unit.

25. The photoacoustic apparatus according to claim 24, further comprising a moving unit configured to move the acoustic probe with respect to the subject holding unit.

26. The photoacoustic apparatus according to claim 25, wherein the moving unit is configured to move the light irradiation portion in association with a movement of the acoustic probe.