Polyhydroxyalkanoate medical textiles and fibers
First Claim
1. A monofilament or multifilament fiber comprising poly-4-hydroxybutyrate homopolymer wherein the multifilament fiber has a tenacity greater than 0.5 g/denier and wherein the monofilament fiber has a tensile strength greater than 126 MPa, wherein the fiber is prepared by a method comprising drying the homopolymer and extruding the polymer at a temperature between 100°
- C. and 220°
C., and drawing the fiber, wherein the method comprises heating the homopolymer r at a temperature greater than 150°
C.
3 Assignments
0 Petitions
Accused Products
Abstract
Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally be combined with autologous, allogenic and/or xenogenic tissues to provide implants with improved mechanical, biological and handling properties.
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Citations
15 Claims
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1. A monofilament or multifilament fiber comprising poly-4-hydroxybutyrate homopolymer wherein the multifilament fiber has a tenacity greater than 0.5 g/denier and wherein the monofilament fiber has a tensile strength greater than 126 MPa, wherein the fiber is prepared by a method comprising drying the homopolymer and extruding the polymer at a temperature between 100°
- C. and 220°
C., and drawing the fiber, wherein the method comprises heating the homopolymer r at a temperature greater than 150°
C. - View Dependent Claims (2, 3, 4)
- C. and 220°
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5. A device comprising one or more monofilament or multifilament fibers comprising poly-4-hydroxybutyrate homopolymer wherein the multifilament fiber has a tenacity of greater than 0.5 g/denier and wherein the monofilament fiber has a tensile strength greater than 126 MPa, wherein the fibers are prepared by a method comprising drying the homopolymer and extruding the homopolymer at a temperature between 100°
- C. and 220°
C., and drawing the fiber, wherein the method comprises heating the homopolymer at a temperature greater than 150°
C. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
- C. and 220°
Specification