Method for amplifying signals from individual nerve fascicles
First Claim
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1. A method comprising:
- receiving, with processing circuitry of an implant device, an electrical signal from a free tissue graft surgically attached to a portion of a nerve of a subject, wherein the electrical signal is received through an electrode that is implanted inside of the free tissue graft and in electrical communication with the free tissue graft, the free tissue graft being surgically attached to the subject such that the free tissue graft is entirely surrounded by and in direct contact with non-grafted tissue of the subject, wherein the free tissue graft is an autograft of tissue that is harvested from the subject, devascularized, and deinnervated prior to being surgically attached to the subject, wherein the portion of the nerve has reinnervated the free tissue graft, and wherein the electrical signal from the free tissue graft has a voltage amplitude of greater than or equal to about 150 microvolts; and
storing, with the processing circuitry, signal data corresponding to the electrical signal from the free tissue graft in a memory accessible to the processing circuitry.
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Abstract
The present disclosure provides methods and systems for receiving, with processing circuitry of an implant device, an electrical signal from a free tissue graft attached to a portion of a nerve (e.g., a nerve branch or fascicle) through an electrical conductor in electrical communication with the free tissue graft (e.g., muscle graft), the nerve having reinnervated the free tissue graft. The electrical signal from the free tissue graft has a voltage amplitude of greater than or equal to about 150 microvolts. The processing circuitry stores signal data corresponding to the electrical signal from the free tissue graft in a memory accessible to the processing circuitry.
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Citations
18 Claims
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1. A method comprising:
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receiving, with processing circuitry of an implant device, an electrical signal from a free tissue graft surgically attached to a portion of a nerve of a subject, wherein the electrical signal is received through an electrode that is implanted inside of the free tissue graft and in electrical communication with the free tissue graft, the free tissue graft being surgically attached to the subject such that the free tissue graft is entirely surrounded by and in direct contact with non-grafted tissue of the subject, wherein the free tissue graft is an autograft of tissue that is harvested from the subject, devascularized, and deinnervated prior to being surgically attached to the subject, wherein the portion of the nerve has reinnervated the free tissue graft, and wherein the electrical signal from the free tissue graft has a voltage amplitude of greater than or equal to about 150 microvolts; and storing, with the processing circuitry, signal data corresponding to the electrical signal from the free tissue graft in a memory accessible to the processing circuitry. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of amplifying a nerve signal in a subject, comprising:
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disposing a portion of a nerve within a free tissue graft and securing the portion of the nerve therein, the free tissue graft being an autograft of tissue that is harvested from the subject, devascularized, and deinnervated prior to being surgically attached to the subject; surgically attaching the free tissue graft directly to the subject such that the free tissue graft is entirely surrounded by and in direct contact with non-grafted tissue of the subject; implanting inside of the free tissue graft at least one electrode for electrical communication with the nerve, wherein the portion of the nerve regenerates within the free tissue graft so that the nerve produces an electrical signal having a voltage amplitude of greater than or equal to about 150 microvolts without any external electrical input; and wherein the electrical signal is received by processing circuitry of an implant device through the at least one electrode, the processing circuitry storing signal data corresponding to the electrical signal in a memory accessible to the processing circuitry. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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Specification