Method for delivering pramlintide into a lumen of the intestinal tract using a swallowable drug delivery device
First Claim
1. A method for delivering Pramlintide into a wall of an intestine, the method comprising:
- providing a swallowable drug delivery device comprising a shell, an actuator having a first configuration and a second configuration and a solid Pramlintide preparation operably coupled to the actuator, the Pramlintide preparation shaped for penetration into the intestine and comprising a therapeutically effective dose of Pramlintide, the preparation being contained within the shell in the first configuration and advanced out of the shell and into the intestinal wall in the second configuration to deliver the Pramlintide preparation into the intestinal wall; and
actuating the actuator within the intestine responsive to a condition in the intestine to deliver the Pramlintide preparation into the wall of the intestine.
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Accused Products
Abstract
Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
170 Citations
20 Claims
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1. A method for delivering Pramlintide into a wall of an intestine, the method comprising:
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providing a swallowable drug delivery device comprising a shell, an actuator having a first configuration and a second configuration and a solid Pramlintide preparation operably coupled to the actuator, the Pramlintide preparation shaped for penetration into the intestine and comprising a therapeutically effective dose of Pramlintide, the preparation being contained within the shell in the first configuration and advanced out of the shell and into the intestinal wall in the second configuration to deliver the Pramlintide preparation into the intestinal wall; and actuating the actuator within the intestine responsive to a condition in the intestine to deliver the Pramlintide preparation into the wall of the intestine. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification