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Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications

  • US 10,314,950 B2
  • Filed: 05/16/2017
  • Issued: 06/11/2019
  • Est. Priority Date: 10/08/2010
  • Status: Active Grant
First Claim
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1. Articles of manufacture comprising:

  • a first hydrogel film;

    a second hydrogel film;

    wherein the first hydrogel film;

    (a) is translucent, desiccated, amorphous, non-synthetic, and non-cytotoxic, (b) includes alginate that is negatively charged and crosslinked with at least one cation;

    (c) includes a first concentration of hyaluronic acid, (d) includes a first matrix that encapsulates a drug, and (e) includes layers that each include the alginate and which are fused to each other;

    wherein the second hydrogel film;

    (a) is translucent, desiccated, amorphous, non-synthetic, and non-cytotoxic, (b) includes alginate that is negatively charged and crosslinked with the at least one cation;

    (c) includes a second concentration of hyaluronic acid, (d) includes a second matrix that encapsulates the drug, and (e) includes layers that each include the alginate and which are fused to each other;

    wherein;

    (a) the first concentration of hyaluronic acid is greater than the second concentration of hyaluronic acid, and (b) the second hydrogel film is configured to degrade faster than the first hydrogel film, when implanted in a patient, in response to the first concentration of hyaluronic acid being greater than the second concentration of hyaluronic acid.

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