Neural locating method

• US 10,321,833 B2
• Filed: 10/05/2016
• Issued: 06/18/2019
• Est. Priority Date: 10/05/2016
• Status: Active Grant

• Current Assignee: Innovative Surgical Solutions, LLC (Johnson & Johnson)
• Original Assignee: Innovative Surgical Solutions, LLC (Johnson & Johnson)
• Inventors: Wybo, Christopher
• Primary Examiner(s): McCrosky, David J.
• Application Number:
  US15/286,333
• Publication Number:
  US 20180092559A1
• Time in Patent Office: 986 Days
• CPC Class Codes: A61B 2018/00071 Electrical conductivity
• CPC Class Codes: A61B 2018/00964 Features of probes
• CPC Class Codes: A61B 2034/105 Modelling of the patient, e.g. for ligaments or bones
• CPC Class Codes: A61B 2034/107 Visualisation of planned trajectories or target regions
• CPC Class Codes: A61B 34/30 Surgical robots
• CPC Class Codes: A61B 34/32 operating autonomously
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/061 Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body A61B1/00158 takes precedence
• CPC Class Codes: A61B 5/1104 induced by stimuli or drugs; A61B5/1102 takes precedence; investigating medicinal preparations G01N33/15
• CPC Class Codes: A61B 5/1107 Measuring contraction of parts of the body, e.g. organ, muscle apparatus for measuring work or force in general G01L
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/294 for nerve conduction study [NCS]
• CPC Class Codes: A61B 5/4029 for evaluating the peripheral nervous systems A61B5/24 takes precedence
• CPC Class Codes: A61B 5/4519 Muscles A61B5/389, A61B5/224 take precedence
• CPC Class Codes: A61B 5/4893 Nerves
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 5/6885 Monitoring or controlling sensor contact pressure
• CPC Class Codes: A61B 5/7425 Displaying combinations of multiple images regardless of image source, e.g. displaying a reference anatomical image with a live image geometric transforms for image registration G06T3/14; enhancement using image fusion G06T5/50; algorithms for registration of images G06T7/30
• CPC Class Codes: B25J 9/1666 Avoiding collision or forbidden zones

Abstract

A method of locating a nerve within an intracorporeal treatment area of a subject includes providing a first electrical stimulus at a first location within the intracorporeal treatment area, providing a second electrical stimulus at a second location within the intracorporeal treatment area, and providing one or more additional electrical stimuli at the second location. The first electrical stimulus does not induce a threshold response of a muscle innervated by the nerve, whereas the second electrical stimulus does induce a response of the muscle. The one or more additional stimuli each have a current magnitude less than the first stimulus and are used to determine a minimum current magnitude that is required to induce the threshold response of the muscle at the second location. This minimum current magnitude is then used to determine a distance from the second location to the nerve.

Claims

1. A method of locating a nerve within an intracorporeal treatment area of a subject, the method comprising:

providing a first electrical stimulus at a first location within the intracorporeal treatment area, wherein the first electrical stimulus has a first current magnitude that does not induce a threshold mechanical response of a muscle innervated by the nerve;

providing a second electrical stimulus at a second location within the intracorporeal treatment area, wherein the second electrical stimulus has the first current magnitude and induces a mechanical response of the muscle that is greater than the threshold mechanical response;

providing one or more additional electrical stimuli at the second location, wherein the one or more additional electrical stimuli each have a current magnitude less than the first current magnitude;

wherein each of the first, second, and one or more additional electrical stimuli are provided from a distal end portion of an elongate stimulator;

wherein the first and second electrical stimuli are provided from an electrode disposed on a central axis of the elongate stimulator;

wherein the one or more additional electrical stimuli are provided from an offset electrode spaced apart from the central axis of the elongate stimulator;

monitoring the threshold mechanical response to the first electrical stimulus and the mechanical response of the muscle to each of the second and one or more additional electrical stimuli using a non-invasive mechanical sensor;

determining, from the one or more additional electrical stimuli, a minimum current magnitude required to induce the threshold mechanical response of the muscle at the second location;

rotating the offset electrode through a plurality of angular positions about the central axis of the elongate stimulator;

determining a distance from the second location to the nerve using the determined minimum current magnitude by determining a distance from each of the plurality of angular positions to the nerve; and

using the determined distance from each of the plurality of angular positions to triangulate a location of the nerve relative to the central axis of the elongate stimulator.

2. The method of claim 1, further comprising registering each of the first location and the second location within a virtual workspace;

and

indicating a portion of the virtual workspace surrounding the first location as not containing the nerve.

3. The method of claim 2, further comprising indicating the presence of the nerve within the workspace at the determined distance from the second location.

4. The method of claim 3, further comprising indicating a second portion of the virtual workspace as not containing the nerve, wherein the second portion surrounds the second location up to the determined distance.

5. The method of claim 3, further comprising providing the virtual workspace to a robotic controller that is operative to control the motion of an end effector disposed within the intracorporeal treatment area;

and

constraining the robotic controller to limit the motion of the end effector according to at least one of the indicated portion of the virtual workspace that does not contain the nerve and the indicated presence of the nerve within the virtual workspace.

6. A method of locating a nerve within an intracorporeal treatment area of a subject, the method comprising:

providing a first electrical stimulus at a first location within the intracorporeal treatment area, wherein the first electrical stimulus has a first current magnitude that does not induce a threshold mechanical response of a muscle innervated by the nerve;

wherein the first electrical stimulus is provided from an electrode disposed on a distal end portion of the elongate stimulator;

providing a second electrical stimulus at a second location within the intracorporeal treatment area, wherein the second electrical stimulus has the first current magnitude and induces a mechanical response of the muscle that is greater than the threshold;

monitoring the threshold mechanical response of the muscle to the first electrical stimulus and the mechanical response of the muscle to the second electrical stimuli using a non-invasive mechanical sensor;

providing one or more additional electrical stimuli at the second location, wherein the one or more additional stimuli each have a current magnitude less than the first current magnitude;

monitoring a location of the distal end portion of the elongate stimulator;

estimating a distance estimate between the monitored location and the nerve using a previously acquired anatomical model;

selecting the first current magnitude using the estimated distance;

determining, from the one or more additional electrical stimuli, a minimum current magnitude required to induce the threshold mechanical response of the muscle at the second location; and

determining a distance from the second location to the nerve using the determined minimum current magnitude;

wherein the first current magnitude is selected from a bounded current range and is the largest current within the bounded current range that is expected to not induce the mechanical response of the muscle when applied at the estimated distance from the nerve.

7. The method of claim 6, further comprising adjusting the anatomical model if the selected first current magnitude induces the mechanical response of the muscle.

8. The method of claim 6, wherein the anatomical model is an acquired model of the subject.

9. A method of locating a nerve within an intracorporeal treatment area of a subject, the method comprising:

applying a first electrical stimulus, having a first current magnitude, at a first location within the intracorporeal treatment area, wherein the first location is greater than a threshold distance from the nerve, and wherein the threshold distance is the greatest distance at which the first electrical stimulus can induce a threshold mechanical response of a muscle that is innervated by the nerve;

wherein the first electrical stimulus is provided from an electrode disposed on a distal end portion of a stimulator;

monitoring the location of the distal end portion of the stimulator;

estimating a distance estimate between the monitored location and the nerve using a previously acquired anatomical model;

selecting the first current magnitude using the estimated distance;

applying a second electrical stimulus, having a second current magnitude, at a second location within the intracorporeal treatment area, wherein the second location is less than the threshold distance from the nerve, and wherein the second current magnitude is less than the first current magnitude;

monitoring a magnitude of the threshold mechanical response to the first electrical stimulus and the mechanical response to the second electrical stimulus using a non-invasive mechanical sensor;

determining a distance from the second location to the nerve from the second current magnitude and the monitored magnitude of the mechanical response of the muscle;

registering each of the first location and the second location within a virtual workspace;

indicating a portion of the virtual workspace surrounding the first location as not containing the nerve; and

indicating the presence of the nerve within the virtual workspace at the determined distance from the second location;

wherein the first current magnitude is selected from a bounded current range and is the largest current within the range that is expected to not induce the mechanical response of the muscle when applied at the estimated distance from the nerve.

10. The method of claim 9, wherein the second current magnitude is a minimum current magnitude that is required to induce the mechanical response of the muscle at the second location.

11. The method of claim 9, wherein the first and second electrical stimuli are each applied by an electrode disposed within the intracorporeal treatment area;

the method further comprising advancing the electrode from the first location to the second location.

12. The method of claim 9, further comprising indicating a second portion of the virtual workspace as not containing the nerve, wherein the second portion surrounds the second location up to the determined distance.

13. The method of claim 9, further comprising adjusting the anatomical model if the selected current magnitude induces the mechanical response of the muscle.

14. The method of claim 9, further comprising providing the virtual workspace to a robotic controller that is operative to control the motion of an end effector disposed within the intracorporeal treatment area;

and

constraining the robotic controller to limit the motion of the end effector according to at least one of the indicated portion of the virtual workspace that does not contain the nerve and the indicated presence of the nerve within the virtual workspace.