System for ingestion event monitoring and method for detecting ingestion events with high accuracy

• US 10,321,849 B2
• Filed: 10/13/2017
• Issued: 06/18/2019
• Est. Priority Date: 10/13/2016
• Status: Active Grant

• Current Assignee: Etectrx Incorporated
• Original Assignee: Etectrx Incorporated
• Inventors: Euliano, Neil R., Myers, Brent, Flores, Glen
• Primary Examiner(s): Lau, Hoi C
• Application Number:
  US15/783,801
• Publication Number:
  US 20180103871A1
• Time in Patent Office: 613 Days
• CPC Class Codes: A61B 2560/0214 of power generation or supply
• CPC Class Codes: A61B 2562/162 Capsule shaped sensor housings, e.g. for swallowing or implantation
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61B 5/4833 Assessment of subject's compliance to treatment

Abstract

System and method for ingestion event detection and monitoring are disclosed. The system comprises: an ingestible microsensor configured to generate a signal representing an ingestion event upon ingestion and contact with stomach fluid of a patient; and a reader device positioned external to the patient and configured to detect the signal representing the ingestion event with at least 95% accuracy.

Claims

1. A system for ingestion event monitoring, the system comprising:

a plurality of ingestible microsensors ingested by a patient around the same time, each ingestible microsensor being configured to generate a signal indicating an ingestion event upon ingestion and contact with stomach fluid, each ingestible microsensor being associated with a unique identifier, and the signal generated by each ingestible microsensor comprising data indicating the unique identifier; and

a reader device positioned external to the patient and configured to detect and differentiate the signal transmitted from each of the plurality of ingestible microsensors with at least 95% accuracy based at least on the unique identifier associated with each ingestible microsensor.

2. The system of claim 1, further comprising a remote database configured to receive data from the reader device via a communication network in real time, and generate and transmit one or more messages at least to the patient based upon received data from the reader device.

3. The system of claim 2, wherein the data comprise information relating to each ingestible microsensor, a unique identifier of the reader device, antenna connection status, charging information of the reader device, reader device battery status, and device status messages.

4. The system of claim 2, wherein the one or more messages comprise automated text messages and reminders to improve a patient'"'"'s medication adherence.

7. The system of claim 1, wherein the reader device requires no skin contact with the patient.

5. A system for ingestion event monitoring, the system comprising:

a plurality of ingestible microsensors ingested by a plurality of patients over a period of time, each ingestible microsensor being configured to generate a signal indicating an ingestion event upon ingestion and contact with stomach fluid, each ingestible microsensor being associated with a unique identifier, and the signal generated by each ingestible microsensor comprising data indicating the unique identifier;

a reader device assigned to each patient, positioned external to each patient following ingestion, and configured to detect the signal transmitted from each of the plurality of ingestible microsensors with at least 95% accuracy; and

a remote database configured to receive data from the reader device via a communication network in real time, and generate and transmit one or more messages at least to each patient based upon received data from the reader device,

wherein the data comprise information relating to each ingestible microsensor, a unique identifier of the reader device, antenna connection status, charging information of the reader device, reader device battery status, and device status messages.

6. The system of claim 5, wherein the one or more messages comprise automated text messages and reminders to improve a patient'"'"'s medication adherence.

8. A method for ingestion event monitoring, the method comprising:

embedding each of a plurality of ingestible microsensors in an oral dosage form to be consumed by a subject; and

having the subject ingest the oral dosage form of each of the plurality of ingestible microsensors;

wherein each ingestible microsensor is configured to generate a signal indicating an ingestion event upon contact with stomach fluid of the subject, and transmit the signal to a reader device positioned external to the subject, wherein each ingestible microsensor is associated with a unique identifier, and the signal generated by each ingestible microsensor comprises data indicating the unique identifier, wherein the reader device is configured to detect and differentiate the signal transmitted from each ingestible microsensor with at least 95% accuracy based at least on the unique identifier associated with each ingestible microsensor.

9. The method of claim 8, wherein each ingestible microsensor comprises circuitry configured to generate power upon being exposed to the stomach fluid of the subject, and each ingestible microsensor is configured to generate and transmit the signal using the power over a period of time following ingestion.