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Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods

  • US 10,321,865 B2
  • Filed: 11/17/2017
  • Issued: 06/18/2019
  • Est. Priority Date: 06/08/2012
  • Status: Active Grant
First Claim
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1. A method for real-time detection of a signal dip for a working electrode of a glucose sensor, the method comprising:

  • periodically performing an electrochemical impedance spectroscopy (EIS) procedure to obtain values of real impedance at 1 kHz for said electrode;

    measuring said electrode'"'"'s current (Isig) over time;

    monitoring, by a microprocessor, said values of real impedance over time;

    based on said monitoring of said values of real impedance, determining, by said microprocessor, whether a dip exists in the signal generated by said working electrode, wherein a signal dip is determined to exist when, as the Isig decreases, the real impedance increases over time; and

    based on the determination that a dip exists in said signal, determining, by said microprocessor, that said working electrode is unreliable for measuring glucose,wherein use of said sensor for glucose measurement is delayed or sensor glucose values are blinded to a user of the sensor by the microprocessor based on the determination that the working electrode is unreliable.

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