Apparatus and method for preparing cosmeceutical ingredients containing epi-dermal delivery mechanisms
First Claim
1. A method for the construction of cosmeceutically bioactive compositions including elastic niosome vesicle epi-dermal delivery vehicles without use of supercritical CO2 and in a continuously operating process, the method comprising:
- forming a liposome solution or mixture of cosmeceutically benevolent phospholipids, the solution being hydrophobic or hydrophilic, the solution including an ingredient from the group consisting of a natural ingredient and a synthetic ingredient, the solution having an aqueous phase;
removing any constituent attributes of water-insolubility from the solution, while operating under conditions to preserve activity of labile biomolecules;
loading the liposome solution and desired hydrophobic bio-actives into an organic solvent residing in a pressure reactor, the pressure reactor having been previously driven to a working temperature less than 31.1°
C.;
pressurizing the reactor with compressed CO2 until reaching a working pressure less than 73.8 bar to produce a resulting CO2-expanded solution, the reactor maintaining a pressure and temperature to prevent the CO2 from going supercritical; and
depressurizing the resulting CO2-expanded solution over an aqueous phase to form vesicular conjugates, the resulting solution containing water soluble cationic or non-ionic surfactants and hydrophilic or hydrophobic bio-actives, wherein the elastic vesicles contain a cosmetically and topically effective active agent, and a cosmetically acceptable carrier or diluent.
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Abstract
The skin serves as a barrier that protects the body from the external environment and prevents water loss. This barrier function also prevents most hydrophilic or hydrophobic and large molecular weight ingredients (>500 kDa) from penetrating intact skin. Until recently, methods to increase stratum corneum permeability were generally not effective enough to make the stratum corneum so permeable that the barrier posed by the viable epidermis mattered. However, that has now changed with the development of the present embodiment'"'"'s physical methods and highly optimized chemical formulations, such that we revisited the permeability of the full epidermis with the example embodiment'"'"'s constructs and not focus only on the stratum corneum. This example embodiment therefore tests the hypothesis that the viable epidermis offers a significant permeability barrier to both small molecules and macromolecules that becomes the rate limiting step.
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Citations
17 Claims
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1. A method for the construction of cosmeceutically bioactive compositions including elastic niosome vesicle epi-dermal delivery vehicles without use of supercritical CO2 and in a continuously operating process, the method comprising:
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forming a liposome solution or mixture of cosmeceutically benevolent phospholipids, the solution being hydrophobic or hydrophilic, the solution including an ingredient from the group consisting of a natural ingredient and a synthetic ingredient, the solution having an aqueous phase; removing any constituent attributes of water-insolubility from the solution, while operating under conditions to preserve activity of labile biomolecules; loading the liposome solution and desired hydrophobic bio-actives into an organic solvent residing in a pressure reactor, the pressure reactor having been previously driven to a working temperature less than 31.1°
C.;pressurizing the reactor with compressed CO2 until reaching a working pressure less than 73.8 bar to produce a resulting CO2-expanded solution, the reactor maintaining a pressure and temperature to prevent the CO2 from going supercritical; and depressurizing the resulting CO2-expanded solution over an aqueous phase to form vesicular conjugates, the resulting solution containing water soluble cationic or non-ionic surfactants and hydrophilic or hydrophobic bio-actives, wherein the elastic vesicles contain a cosmetically and topically effective active agent, and a cosmetically acceptable carrier or diluent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification