Tumescent drug delivery
First Claim
1. A method of subcutaneous delivery of a drug or a therapeutic agent to a subject to treat a localized condition, the method comprising:
- (a) preparing a liquid composition consisting of the drug or the therapeutic agent dissolved in a tumescent solution, wherein the tumescent solution consists of a local anesthetic, a vasoconstrictor and a pharmaceutically acceptable carrier, and(b) delivering a mass of the liquid composition subcutaneously to a localized tissue in the subject, wherein the drug or the therapeutic agent treats the localized condition in the localized tissue,wherein a concentration of the drug or the therapeutic agent subcutaneously delivered exceeds a concentration of the drug or the therapeutic agent that can be safely achieved by intravenous delivery, and wherein an amount of the drug or the therapeutic agent located at an outer boundary of the mass of fluid and available for absorption is less than an amount of the drug or the therapeutic agent located within a central portion of the mass of fluid and virtually isolated from the systemic circulation by virtue of capillary vasoconstriction,wherein the localized condition is selected from the group consisting of a tumor, surgical site infection, chronic post-operative pain, risk of deep vein thrombosis, risk of post-operative thromboembolism and a burn wound.
1 Assignment
0 Petitions
Accused Products
Abstract
A method of subcutaneous delivery of a drug or a therapeutic agent to a subject comprising administering to said subject a mass of fluid of a tumescent composition comprising: (a) the drug or the therapeutic agent; (b) a vasoconstrictor; and (c) a pharmaceutically acceptable carrier, wherein a relatively large total amount of the drug is isolated from systemic circulation in the subject because only drug in an outer boundary of the mass of fluid is the available for absorption, whereas a portion of the drug located within a central portion of the mass of fluid is virtually isolated from the systemic circulation by virtue of profound capillary vasoconstriction, wherein epinephrine-induced vasoconstriction dramatically slows systemic absorption of the drug or therapeutic agent, and wherein the mass of fluid is a reservoir that delivers the drug or the therapeutic agent to the subject with pharmacokinetics that are analogous to a slow-release oral tablet or a slow constant intravenous (IV) Infusion.
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Citations
19 Claims
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1. A method of subcutaneous delivery of a drug or a therapeutic agent to a subject to treat a localized condition, the method comprising:
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(a) preparing a liquid composition consisting of the drug or the therapeutic agent dissolved in a tumescent solution, wherein the tumescent solution consists of a local anesthetic, a vasoconstrictor and a pharmaceutically acceptable carrier, and (b) delivering a mass of the liquid composition subcutaneously to a localized tissue in the subject, wherein the drug or the therapeutic agent treats the localized condition in the localized tissue, wherein a concentration of the drug or the therapeutic agent subcutaneously delivered exceeds a concentration of the drug or the therapeutic agent that can be safely achieved by intravenous delivery, and wherein an amount of the drug or the therapeutic agent located at an outer boundary of the mass of fluid and available for absorption is less than an amount of the drug or the therapeutic agent located within a central portion of the mass of fluid and virtually isolated from the systemic circulation by virtue of capillary vasoconstriction, wherein the localized condition is selected from the group consisting of a tumor, surgical site infection, chronic post-operative pain, risk of deep vein thrombosis, risk of post-operative thromboembolism and a burn wound. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of subcutaneous delivery of a drug or a therapeutic agent to a subject to treat a localized condition, the method comprising:
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(a) providing a liquid composition consisting of the drug or the therapeutic agent dissolved in a tumescent solution, wherein the tumescent solution consists of a vasoconstrictor and a pharmaceutically acceptable carrier, and (b) delivering a mass of the liquid composition subcutaneously to a localized tissue in the subject, wherein the drug or the therapeutic agent treats the localized condition in the localized tissue, wherein a concentration of the drug or the therapeutic agent subcutaneously delivered exceeds a concentration of the drug or the therapeutic agent that can be safely achieved by intravenous delivery, and wherein an amount of the drug or the therapeutic agent located at an outer boundary of the mass of fluid and available for absorption is less than an amount of the drug or the therapeutic agent located within a central portion of the mass of fluid and virtually isolated from the systemic circulation by virtue of capillary vasoconstriction, and wherein the localized condition is selected from the group consisting of a tumor, surgical site infection, chronic post-operative pain, risk of deep vein thrombosis, risk of post-operative thromboembolism and a burn wound.
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Specification