Topical tetracycline compositions
DCFirst Claim
1. A method of treating rosacea, comprising administeringa waterless foam composition comprisinga minocycline and a foamable carrier, the carrier comprising:
- a) at least one hydrophobic oil; and
b) an agent comprising (i) at least one fatty alcohol and at least one wax;
(ii) at least one fatty acid and at least one wax;
(iii) at least one fatty alcohol, at least one fatty acid, and at least one wax;
(iv) a wax comprising a hydrogenated oil;
or (v) a combination of two or more waxes;
wherein the composition does not contain one or more minocycline incompatible substance selected from the group consisting of dimethyl sulfoxide (DMSO), dimethylformamide (DMF), acetonitrile, acetone, methyl ethyl ketone, 1,4-dioxane, tetrahydrofuran (THF), N-methylpyrrolidone, pyridine, piperidine, N-methyl-2-pyrrolidone and 1-methyl-2-pyrrolidinone), azone (1-dodecylazacycloheptan-2-one), dimethyl isosorbide, glycerin, ethanol, propylene glycol, butylene glycol, PEG 200, hexylene glycol, PEG 400, diethylene glycol monoethyl ether, pomegranate seed oil, isostearic acid, and ethylcellulose;
wherein the composition does not contain a surfactant; and
wherein the composition does not contain a polyol.
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Abstract
A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity or the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.
1019 Citations
30 Claims
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1. A method of treating rosacea, comprising administering
a waterless foam composition comprising a minocycline and a foamable carrier, the carrier comprising: -
a) at least one hydrophobic oil; and b) an agent comprising (i) at least one fatty alcohol and at least one wax;
(ii) at least one fatty acid and at least one wax;
(iii) at least one fatty alcohol, at least one fatty acid, and at least one wax;
(iv) a wax comprising a hydrogenated oil;
or (v) a combination of two or more waxes;wherein the composition does not contain one or more minocycline incompatible substance selected from the group consisting of dimethyl sulfoxide (DMSO), dimethylformamide (DMF), acetonitrile, acetone, methyl ethyl ketone, 1,4-dioxane, tetrahydrofuran (THF), N-methylpyrrolidone, pyridine, piperidine, N-methyl-2-pyrrolidone and 1-methyl-2-pyrrolidinone), azone (1-dodecylazacycloheptan-2-one), dimethyl isosorbide, glycerin, ethanol, propylene glycol, butylene glycol, PEG 200, hexylene glycol, PEG 400, diethylene glycol monoethyl ether, pomegranate seed oil, isostearic acid, and ethylcellulose; wherein the composition does not contain a surfactant; and wherein the composition does not contain a polyol. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method of treating rosacea, comprising administering
a waterless composition comprising a carrier and 1% to 10% by weight of the composition of a minocycline, wherein the carrier comprises: -
a) at least one hydrophobic oil; and b) an agent comprising (i) at least one fatty alcohol and at least one wax;
(ii) at least one fatty acid and at least one wax;
(iii) at least one fatty alcohol, at least one fatty acid, and at least one wax;
(iv) a wax comprising a hydrogenated oil;
or (v) a combination of two or more waxes;wherein the composition does not contain a surfactant; and wherein the composition does not contain a polyol. - View Dependent Claims (17, 18, 19, 20)
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21. A method of treating rosacea, comprising administering
a foam produced from a foamable composition comprising a carrier and a liquified or compressed gas propellant, the carrier comprising: -
a) a tetracycline antibiotic; b) a combination of two or more hydrophobic oils, wherein at least one of the hydrophobic oils is a light mineral oil and the other hydrophobic oil comprises a heavy mineral oil, soybean oil, and/or coconut oil; and c) a combination of two or more fatty alcohols, wherein at least one of the fatty alcohols is stearyl alcohol; wherein the hydrophobic oils are present at between about 70% and 95% by weight of the carrier; and wherein the ratio of the carrier to the propellant is between about 100;
1 and about 100;
25. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28)
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29. A method of treating rosacea, comprising administering
a foam produced from a foamable composition comprising a carrier and a liquified or compressed gas propellant, the carrier comprising: -
a) a minocycline; b) a combination of two or more hydrophobic oils, wherein at least one of the hydrophobic oils is a light mineral oil and the other hydrophobic oil comprises a heavy mineral oil, soybean oil, and/or coconut oil; c) a combination of two or more fatty alcohols, wherein at least one of the fatty alcohols is stearyl alcohol; and d) at least one wax; wherein the hydrophobic oils are present at between about 70% and 95% by weight of the carrier; wherein the fatty alcohols and the wax are present at a ratio between about 4;
1 and 3;
2; andwherein the ratio of the carrier to the propellant is between about 100;
1 and about 10025. - View Dependent Claims (30)
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Specification