Unique self-assembled poly-amidoamine polymers and their electrochemical reactivity

• US 10,323,008 B2
• Filed: 06/05/2015
• Issued: 06/18/2019
• Est. Priority Date: 06/06/2014
• Status: Active Grant

• Current Assignee: Arizona Board of Regents (University of Arizona)
• Original Assignee: Arizona Board of Regents (University of Arizona)
• Inventors: LaBelle, Jeffrey, Saxman, Trevor, Haselwood, Brittney
• Primary Examiner(s): Kahn, Rachel
• Application Number:
  US15/316,468
• Publication Number:
  US 20170190674A1
• Time in Patent Office: 1,474 Days
• Field of Search: None
• CPC Class Codes: C07D 245/04 condensed with carbocyclic rings or ring systems
• CPC Class Codes: C07F 15/02 Iron compounds
• CPC Class Codes: C08G 73/028 Polyamidoamines
• CPC Class Codes: C08G 83/003 Dendrimers
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose

Abstract

Synthesis of novel and unique PAMAM (poly-amidoamine) polymers. PAMAM polymers can be grown by systematic alternation between ethylenediamine (EDA) and methacrylate. By taking advantage of the alternating terminal ends, successive generations G1 and G0.5 were combined under acidic conditions with Pluronic P123 as a liquid-crystal template. The resulting polymer was imaged with TEM and the product was circular and amorphous of no characteristic size ranging between about 5 nm to about 600 nm, with remarkable electrochemical activity unseen in any of the generations of PAMAM. Applications of this electroactive poly-amidoamine organic polymer include use as a new electron transfer reagent for amperometric biosensors.

Claims

1. A chemical composition comprising:

one or more polymers capable of conducting an electric current through a solution, the one or more polymers including at least one PAMAM polymer configured to perform in-vivo electrochemical biomarker detection, wherein said at least one PAMAM polymer comprises;