Anti-PD-1 antibodies and methods of use thereof
First Claim
Patent Images
1. An isolated antibody that specifically binds to human PD-1, comprising a heavy chain variable region comprising complementarity determining regions CDRH1, CDRH2, and CDRH3 and a light chain variable region comprising complementarity determining regions CDRL1, CDRL2, and CDRL3, wherein:
- (a) CDRH1 comprises the amino acid sequence of SYGMH (SEQ ID NO;
1);
(b) CDRH2 comprises the amino acid sequence of VIWX1DGSNX2YYADSVX3G (SEQ ID NO;
32), whereinX1 is Y or F;
X2 is K or E; and
X3 is K or M;
(c) CDRH3 comprises the amino acid sequence of NX1DX2 (SEQ ID NO;
33), whereinX1 is G or V; and
X2 is H or Y;
(d) CDRL1 comprises the amino acid sequence of RASQSVSSNLA (SEQ ID NO;
4);
(e) CDRL2 comprises the amino acid sequence of GASTRAT (SEQ ID NO;
5); and
(f) CDRL3 comprises the amino acid sequence of QQYNNWPRT (SEQ ID NO;
6).
5 Assignments
0 Petitions
Accused Products
Abstract
The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
106 Citations
94 Claims
-
1. An isolated antibody that specifically binds to human PD-1, comprising a heavy chain variable region comprising complementarity determining regions CDRH1, CDRH2, and CDRH3 and a light chain variable region comprising complementarity determining regions CDRL1, CDRL2, and CDRL3, wherein:
-
(a) CDRH1 comprises the amino acid sequence of SYGMH (SEQ ID NO;
1);(b) CDRH2 comprises the amino acid sequence of VIWX1DGSNX2YYADSVX3G (SEQ ID NO;
32), whereinX1 is Y or F; X2 is K or E; and X3 is K or M; (c) CDRH3 comprises the amino acid sequence of NX1DX2 (SEQ ID NO;
33), whereinX1 is G or V; and X2 is H or Y; (d) CDRL1 comprises the amino acid sequence of RASQSVSSNLA (SEQ ID NO;
4);(e) CDRL2 comprises the amino acid sequence of GASTRAT (SEQ ID NO;
5); and(f) CDRL3 comprises the amino acid sequence of QQYNNWPRT (SEQ ID NO;
6). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 88, 89)
-
-
24. An isolated antibody that specifically binds to human PD-1, comprising a heavy chain variable region comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 15, 17, and 26-31.
- View Dependent Claims (25, 26, 73, 74, 75, 90)
-
27. An isolated antibody that specifically binds to human PD-1, comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 52, 53, 54, 55, or 56.
- View Dependent Claims (28, 29, 76, 77, 78, 91)
-
30. An isolated antibody that specifically binds to human PD-1, comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 18, 20, 21, 22, or 23.
- View Dependent Claims (31, 32, 79, 80, 81, 92)
- 33. An isolated antibody that specifically binds to human PD-1, comprising a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 35. An isolated antibody that specifically binds to human PD-1, comprising a light chain comprising the amino acid sequence of SEQ ID NO:
Specification