Bio-chips and nano-biochips

• US 10,327,644 B2
• Filed: 03/14/2016
• Issued: 06/25/2019
• Est. Priority Date: 06/25/2012
• Status: Active Grant

• Current Assignee: International Business Machines Corporation
• Original Assignee: International Business Machines Corporation
• Inventors: Kline, Eric V.
• Primary Examiner(s): Messersmith, Eric J
• Application Number:
  US15/069,563
• Publication Number:
  US 20160192839A1
• Time in Patent Office: 1,198 Days
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 5/0028 Body tissue as transmission medium, i.e. transmission systems where the medium is the human body
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/036 by means introduced into body tracts A61B5/032 and A61B5/035 take precedence
• CPC Class Codes: A61B 5/07 Endoradiosondes
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/4041 Evaluating nerves condition
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6861 Capsules, e.g. for swallowing or implanting
• CPC Class Codes: A61B 8/085 for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00

Abstract

A biochip device, or a system of biochips, providing diagnostic testing, sensing and therapeutic functionality useful in diagnosis and treatment of a variety of physiological maladies.

Claims

1. A system for monitoring one or more medical conditions in a subject, the system comprising:

at least two biocompatible microchips, each microchip comprising;

a housing including a biocompatible coating or covering,

a first semiconductor substrate situated in said housing upon which is located one or more sensor devices for sensing conditions and providing measurements within said subject;

a second semiconductor substrate situated in said housing including a programmed control unit and an associated memory block configured for controlling operations on said microchip in response to received external command or a sensed condition within said subject;

a communications sub-system situated in said housing including one or more communications devices for transmitting signals to and receiving signals from a communications receiver device external to said subject;

a plurality of storage vessels for storing therapeutic or diagnostic materials; and

an output fluid connector partially housed in said housing in fluid communication with said one or more said storage vessels for outputting said therapeutic or diagnostic materials under control of said programmed control unit,

wherein said at least two biocompatible microchips are interdependent, each biocompatible microchip adapted for implantation in a subject'"'"'s body for sensing a mitosis rate in a local tissue, a first biocompatible microchip of said at least two biocompatible microchips having one or more measurement sensor devices affixed at a local area of a tissue being monitored in a subject and a second biocompatible microchip of said at least two biocompatible microchips in communication with the first biocompatible microchip and providing a stimulus signal for receipt by the first biocompatible microchip, said first biocompatible microchip sensing the stimulus signal and detecting a phase shift in wave components of the stimulus signal for use in detecting the local tissue mitosis rate.

2. The system as claimed in claim 1, each microchip further comprising:

an input fluid connector partially housed in said housing and under programmed control for obtaining one or more biological samples from the subject, wherein one or more of said plurality of storage vessels provide a reactant for reaction with a received biological sample in a reactant chamber located within said housing; and

,

said programmed controller causing a sensor device to sense a resulting condition of said reacted biological sample in said reactant chamber resulting according to said reaction.

3. The system as claimed in claim 2, wherein said programmed controller initiates a reacted biological sample is output to said subject via said output fluid connector.

4. The system as claimed in claim 1, each microchip further comprising:

a power source located within said housing for powering said communications sub-system and said programmed control unit.

5. The system as claimed in claim 4, each microchip further comprising:

a radiofrequency antenna operatively connecting said receiver and transmitter of said communications sub-system for receiving communicated control signals for controlling sensing and reacting operations within said housing.

6. The system as claimed in claim 4 wherein said power source comprises a battery.

7. The system as claimed in claim 5 wherein said transmitter device of said communications sub-system is adapted to communicate signals from sensor measurements to an external receiving device, or, communicate control signals from said controller unit to a further communications receiver device located within the subject.

8. The system of claim 1, wherein one of said at least two biocompatible microchips is mobile within the subject.

9. The system of claim 1, wherein one of said at least two biocompatible microchips is coordinated to operate in conjunction with one or more additional mobile biocompatible microchips within the subject.

10. The system of claim 4, wherein each said biocompatible microchip is powered by a battery within the microchip.

11. The system of claim 1, wherein said first semiconductor substrate further includes a micro-electro-mechanical system (MEMS) operative under programmed control for providing a reaction with a biological sample.

12. The system of claim 1, wherein said communications subsystem communicates according to a wireless IEEE 802.x communications protocol.

13. The system of claim 1, wherein said communications subsystem includes an ultrasonic frequency receiver and transmitter for receiving and sending ultrasonic signals for reaction with biological structures internal said subject.

14. The system of claim 4, wherein said power source of the biocompatible microchip provides power to said microchip via inductive or radiofrequency coupling.

15. The system of claim 1, wherein the one or more medical conditions comprise:

kidney disease, liver dysfunction, pancreatitis, thyroid diseases, insulin resistance, paralysis due to severed or dysfunctional neurological pathways, and brain biochemical imbalances.

16. The system of claim 14, wherein a biocompatible microchip of said at least two biocompatible microchips has no battery or integrated power source, said biocompatible microchip configured to provide a single measurement function using power continuously fed to the biocompatible microchip through said inductive or RF coupling.

17. The system of claim 5, wherein each said biocompatible microchip performs sensing functions, a sensing function performed at said biocompatible microchip comprising:

sensing measurement of one or more of;

physiologic temperature, pressure, intravenous (I-V) concentrations, one or more chemical/biochemical concentrations, fibrosis, or necrosis, or in sensing of nerve pathways and/or proprioception.

18. The system of claim 5, wherein said at least two interdependent biocompatible microchips function as a dosimeter to perform one or more of:

pharmocologic chemical measuring or radiation measuring.