Sensor systems, devices, and methods for continuous glucose monitoring
First Claim
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1. A method for real-time calibration of a glucose sensor for measuring the level of glucose in a body of a user, said glucose sensor including physical sensor electronics, a microcontroller, and a working electrode, the method comprising:
- (a) performing, by said microcontroller, an electrochemical impedance spectroscopy (EIS) procedure to obtain imaginary impedance values for said working electrode;
(b) calculating, by said microcontroller, a reference range associated with said values of imaginary impedance, said range being a function of the difference between the current imaginary impedance value and prior imaginary impedance values, wherein said reference range is calculated according to the relation range=3×
median(|xi−
xj|), wherein j represents the current imaginary impedance value, and i represents the most recent 2 hours of imaginary impedance values;
(c) comparing, by the microcontroller, the current value of imaginary impedance to the reference range;
(d) based on said comparison, determining, by the microcontroller, a time interval until the next calibration; and
(e) setting, by the microcontroller, an alarm for performing said next calibration within said time interval based on said comparison.
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Abstract
Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.
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Citations
6 Claims
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1. A method for real-time calibration of a glucose sensor for measuring the level of glucose in a body of a user, said glucose sensor including physical sensor electronics, a microcontroller, and a working electrode, the method comprising:
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(a) performing, by said microcontroller, an electrochemical impedance spectroscopy (EIS) procedure to obtain imaginary impedance values for said working electrode; (b) calculating, by said microcontroller, a reference range associated with said values of imaginary impedance, said range being a function of the difference between the current imaginary impedance value and prior imaginary impedance values, wherein said reference range is calculated according to the relation range=3×
median(|xi−
xj|), wherein j represents the current imaginary impedance value, and i represents the most recent 2 hours of imaginary impedance values;(c) comparing, by the microcontroller, the current value of imaginary impedance to the reference range; (d) based on said comparison, determining, by the microcontroller, a time interval until the next calibration; and (e) setting, by the microcontroller, an alarm for performing said next calibration within said time interval based on said comparison. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification