Endoluminal device for in vivo delivery of bioactive agents
First Claim
Patent Images
1. A method of making an implantable device comprising:
- a. forming a base layer of structural material;
b. depositing a pattern of sacrificial material onto the base layer, the sacrificial material forming internal cavity regions;
c. depositing at least a second layer of structural material over the sacrificial material and over the base layer forming a strut having a an upper surface, lower surface, and lateral surface bounding the sacrificial material;
d. forming one or more microholes in the structural material providing fluid flow communication between the sacrificial material and the area external to the at least one of upper surface, lower surface, or lateral surface; and
e. removing the sacrificial material forming at least one internal cavity bound intermediate the upper surface, lower surface, and lateral surface wherein the one or more microholes are in fluid communication with the internal cavity.
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Abstract
The present invention consists of an implantable structural element for in vivo delivery of bioactive active agents to a situs in a body. The implantable structural element may be configured as an implantable prosthesis, such as an endoluminal stent, cardiac valve, osteal implant or the like, which serves a dual function of being prosthetic and a carrier for a bioactive agent. Alternatively, the implantable structural element may simply be an implantable article that serves the single function of acting as a time-release carrier for the bioactive agent.
79 Citations
14 Claims
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1. A method of making an implantable device comprising:
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a. forming a base layer of structural material; b. depositing a pattern of sacrificial material onto the base layer, the sacrificial material forming internal cavity regions; c. depositing at least a second layer of structural material over the sacrificial material and over the base layer forming a strut having a an upper surface, lower surface, and lateral surface bounding the sacrificial material; d. forming one or more microholes in the structural material providing fluid flow communication between the sacrificial material and the area external to the at least one of upper surface, lower surface, or lateral surface; and e. removing the sacrificial material forming at least one internal cavity bound intermediate the upper surface, lower surface, and lateral surface wherein the one or more microholes are in fluid communication with the internal cavity. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An endoluminal stent, comprising:
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a. a plurality of tubular struts, each tubular strut of the plurality of tubular struts having an external surface, an internal surface, a wall thickness intermediate the external and internal surfaces that is substantially uniform about a transverse cross section of the tubular strut, and an internal cavity concentric entirely within the tubular strut along a longitudinal axis of the tubular strut; b. a plurality of micropores passing through the wall thickness distributed about the entire circumference of the tubular strut that permit generally omnidirectional fluid flow therethrough from the internal cavity; c. a bioactive agent disposed within the internal cavity that elutes from the internal cavity through at least some of the plurality of micropores; and d. wherein the plurality of struts are disposed circumferentially forming a tubular stent having a stent central lumen. - View Dependent Claims (12, 13, 14)
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Specification