Compositions for the inhibition of Giardia lamblia

• US 10,328,132 B2
• Filed: 08/10/2015
• Issued: 06/25/2019
• Est. Priority Date: 08/08/2014
• Status: Active Grant

• Current Assignee: Ecole Nationale Veterinaire D'Alfort, Institut National de La Recherche Agronomique, Museum National D Histoire Naturelle
• Original Assignee: Institut National de La Recherche Agronomique
• Inventors: Bermudez-Humaran, Luis G., Allain, Thibault, Florent, Isabelle, Langella, Philippe, Grellier, Philippe, Travers, Marie-Agnes, Polack, Bruno
• Primary Examiner(s): Leavitt, Maria G
• Application Number:
  US15/501,587
• Publication Number:
  US 20170216415A1
• Time in Patent Office: 1,415 Days
• Field of Search: None
• CPC Class Codes: A23L 33/135 Bacteria or derivatives thereof, e.g. probiotics
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2400/113 Acidophilus
• CPC Class Codes: A23V 2400/145 Gasseri
• CPC Class Codes: A23V 2400/151 Johnsonii
• CPC Class Codes: A61K 35/741 Probiotics probiotic yeast, e.g. saccharomyces A61K36/06
• CPC Class Codes: A61K 35/744 Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 38/164 from bacteria
• CPC Class Codes: A61K 38/46 Hydrolases (3)
• CPC Class Codes: A61K 38/50 acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
• CPC Class Codes: A61P 33/02 Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
• CPC Class Codes: C12N 9/80 acting on amide bonds in linear amides (3.5.1)
• CPC Class Codes: C12Y 305/01024 Choloylglycine hydrolase (3.5.1.24), i.e. bile salt hydrolase
• CPC Class Codes: G01D 5/24 by varying capacitance
• CPC Class Codes: H03K 17/955 using a capacitive detector
• CPC Class Codes: H03K 2217/960745 Capacitive differential; e.g. comparison with reference capacitance
• CPC Class Codes: H03K 2217/96075 involving bridge circuit
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to a composition exhibiting a bile-salt hydrolase activity for its use for the treatment or the prevention of giardiasis, said composition comprising a bile-salt hydrolase (BSH) enzyme, a bacterium able to secrete a BSH, a recombinant host cell able to secrete a BSH, or a combination thereof. The present invention also relates to the use of a composition exhibiting a BSH activity for the treatment or the prevention of giardiasis, and to a pharmaceutical composition or a food composition comprising, as an active principle, a BSH, a lactic acid bacterium able to secrete a BSH, or a recombinant host cell able to secrete a BSH.

Claims

1. A method of treating giardiasis, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a lactic acid bacterium that secretes at least one bile salt hydrolase (BSH) enzyme, wherein said lactic acid bacterium is selected from the group consisting of Lactobacillus johnsonii and Lactobacillus gasseri filed at CNCM, Institut Pasteur, Paris, France, under references 1-4885 and 1-4884, respectively, on Aug. 7, 2014.

2. The method according to claim 1, wherein the subject in need thereof is a human being.

3. The method according to claim 1, wherein the subject in need thereof is an animal.

4. The method according to claim 3, wherein the animal is a pig or cow.