Compositions and methods for transport across the blood brain barrier
First Claim
Patent Images
1. A composition comprising the sequence of SEQ ID NO:
- 10, or SEQ ID SEQ ID NO;
2 with SEQ ID NO;
8 inserted between the third and fourth residues of SEQ ID NO;
2, or SEQ ID NO;
3 with SEQ ID NO;
8 inserted between the third and fourth residues of SEQ ID NO;
3, or SEQ ID NO;
5 with SEQ ID NO;
8 inserted between the third and fourth residues of SEQ ID NO;
5.
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Accused Products
Abstract
Compositions and methods are provided including a transporter peptide derived from the loop2 domain of the neuronally-derived lynx1 protein which can be conjugated to an effector agent to form a transporter-effector complex for transport of the therapeutic effector agent to a target that is found across the blood brain barrier.
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Citations
16 Claims
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1. A composition comprising the sequence of SEQ ID NO:
- 10, or SEQ ID SEQ ID NO;
2 with SEQ ID NO;
8 inserted between the third and fourth residues of SEQ ID NO;
2, or SEQ ID NO;
3 with SEQ ID NO;
8 inserted between the third and fourth residues of SEQ ID NO;
3, or SEQ ID NO;
5 with SEQ ID NO;
8 inserted between the third and fourth residues of SEQ ID NO;
5. - View Dependent Claims (2, 3, 4)
- 10, or SEQ ID SEQ ID NO;
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5. A composition comprising, a transporter peptide conjugate comprising:
- an effector agent; and
a transporter peptide comprising;
SEQ ID NO;
10, or SEQ ID SEQ ID NO;
2 with SEQ ID NO;
8 inserted between the third and fourth residues of SEQ ID NO;
2, or SEQ ID NO;
3 with SEQ ID NO;
8 inserted between the third and fourth residues of SEQ ID NO;
3, or SEQ ID NO;
5 with SEQ ID NO;
8 inserted between the third and fourth residues of SEQ ID NO;
5, the effector agent being conjugated to the transporter peptide. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
- an effector agent; and
Specification