Sensor system for drug delivery device, drug delivery device having the same and method of using the same

• US 10,328,203 B2
• Filed: 10/20/2016
• Issued: 06/25/2019
• Est. Priority Date: 01/21/2009
• Status: Active Grant

• Current Assignee: Xerox Corporation (Xerox Holdings Corp.)
• Original Assignee: Palo Alto Research Center, Inc. (Xerox Holdings Corp.)
• Inventors: Uhland, Scott Albert, Peeters, Eric, Preas, Bryan Thomas, Martini, Joerg
• Primary Examiner(s): Price, Nathan R
• Assistant Examiner(s): Snyder, Melissa A
• Application Number:
  US15/298,456
• Publication Number:
  US 20170035970A1
• Time in Patent Office: 978 Days
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 5/16836 by sensing tissue properties at the infusion site, e.g. for detecting infiltration detecting tissue temperature for diagnostic purposes A61M39/0247
• CPC Class Codes: A61M 5/1684 by detecting the amount of infusate remaining, e.g. signalling end of infusion
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

A system for use with a drug delivery device includes a sensor unit and a deactivation unit operatively coupled to an output of the sensor unit and to a drug-retaining region of the drug delivery device, wherein the drug-retaining region contains a drug. The sensor unit is configured to detect a characteristic of a local environment and generate an output corresponding to a value of the detected characteristic. The deactivation unit is configured to render the drug ineffective when the output of the sensor unit satisfies a predetermined condition.

Claims

1. A system for use with a drug delivery device having a drug in a reservoir, the system comprising:

a sensor unit configured to detect a characteristic in a local environment and generate an output corresponding to a value of the detected characteristic; and

a deactivation unit operatively coupled to the sensor unit and to the reservoir, the deactivation unit having control circuitry and an energy source, the control circuitry configured to initiate application of energy from the energy source to the reservoir;

wherein the control circuitry is configured to apply the energy to the reservoir to neutralize the drug in the reservoir when the sensor unit detects a condition in the local environment using the characteristic of the local environment.

2. The system of claim 1, wherein the sensor unit configured to detect a condition in the local environment detects a characteristic of a user.

3. The system of claim 2, wherein the sensor unit configured to detect a condition in the local environment further comprises a user engageable element coupled to the drug delivery device.

4. The system of claim 1, wherein the sensor unit configured to detect a condition in the local environment further comprises at least one characteristic in the local environment selected from the group consisting of a mechanical characteristic, a thermal characteristic, an electrical characteristic, an optical characteristic and a chemical characteristic.

5. The system of claim 1, wherein the condition is satisfied when the value of the detected characteristic in the local environment is outside a predetermined range.

6. The system of claim 1, wherein the condition is satisfied when the value of the detected characteristic in the local environment is within a predetermined range.

7. The system of claim 1, wherein the condition is satisfied when a rate at which the value of the detected characteristic in the local environment changes is outside a predetermined range.

8. The system of claim 1, wherein the condition is satisfied when a user engages with a user engageable element coupled to the drug delivery device.

9. The system of claim 1, wherein the drug is transportable from the reservoir to a user upon application of energy from the energy source to the reservoir.

10. The drug delivery device of claim 9, wherein the deactivation unit is further configured to discontinue the application of energy from the energy source to the reservoir when the output of the sensor unit satisfies the condition.

11. A system for use with a drug delivery device having a drug in a reservoir, the system comprising:

a sensor unit configured to detect a characteristic in a local environment and generate an output corresponding to a value of the detected characteristic; and

a deactivation unit operatively coupled to the sensor unit and to the reservoir, the deactivation unit having control circuitry and a capsule, the control circuitry configured to expose the capsule to the reservoir;

wherein the control circuitry is configured to expose the capsule to the reservoir to neutralize the drug when the sensor unit detects a condition in the local environment using the characteristic of the local environment.

12. The system of claim 11, wherein the drug delivery device includes at least one selected from the group consisting of an inhaler, a syringe, an intravenous bag, an implanted drug delivery system, a transdermal patch, a pill bottle, a liquid medicine bottle and an eyedropper.

13. The system of claim 11, further comprising a housing, wherein the reservoir is located within the housing, and wherein the sensor unit comprises at least one sensor coupled to the housing.

14. The system of claim 11, wherein the capsule is degradable and contains material to neutralize the drug in the reservoir when the condition is satisfied.

15. The system of claim 11, further comprising a user engageable element that is detectable by the sensor unit when a user engages with the user engageable element.

16. A method for using of a drug delivery device having a reservoir operatively coupled to a deactivation unit and a sensor unit, the reservoir containing a drug, the deactivation unit having control circuitry and an energy source, the method comprising:

detecting, using the sensor unit, a characteristic in a local environment;

outputting, at the sensor unit, a signal corresponding to the detected characteristic;

receiving the output value of the signal corresponding to the detected characteristic at the control circuitry; and

responsive to receiving the output value at the control circuitry, outputting a signal from the control circuitry to the energy source and applying energy from the energy source to the reservoir to neutralize the drug when the sensor unit outputs a signal indicating detection of a condition in the local environment using the characteristic in the local environment.

17. The method of claim 16, wherein said outputting outputs the signal when the value of the detected characteristic in the local environment is outside a predetermined range.

18. The method of claim 16, wherein said outputting outputs the signal when the value of the detected characteristic in the local environment is within a predetermined range.

19. The method of claim 16, wherein said detecting detects at least one characteristic in a local environment selected from the group consisting of a mechanical characteristic, a thermal characteristic, an electrical characteristic, an optical characteristic and a chemical characteristic.

20. A method of use of a drug delivery device having a reservoir operatively coupled to a deactivation unit and a sensor unit, the reservoir containing a drug, the deactivation unit having control circuitry and a capsule, the control circuitry configured to expose the capsule to the reservoir, the method comprising:

detecting, using the sensor unit, a characteristic in a local environment;

outputting, at the sensor unit, an output value corresponding to the detected characteristic;

receiving the output value at the control circuitry; and

responsive to receiving the output value corresponding to the detected characteristic at the control circuitry, outputting a signal from the control circuitry to the energy source and exposing the capsule to the reservoir to neutralize a drug in the reservoir when the sensor unit outputs an output value indicating the detection of a condition in the local environment using the characteristic of the local environment.

21. The method of claim 20, wherein said outputting outputs the output value when the output value of the detected characteristic in the local environment is outside a predetermined range.

22. The method of claim 20, wherein said outputting outputs the output value when the output value of the detected characteristic in the local environment is within a predetermined range.

23. The method of claim 20, wherein said detecting detects at least one characteristic in a local environment selected from the group consisting of a mechanical characteristic, a thermal characteristic, an electrical characteristic, an optical characteristic and a chemical characteristic.