Blow-molded syringe for use with an injector

• US 10,328,208 B2
• Filed: 10/31/2014
• Issued: 06/25/2019
• Est. Priority Date: 11/01/2013
• Status: Active Grant

• Current Assignee: Bayer Healthcare LLC (Bayer AG)
• Original Assignee: Bayer Healthcare LLC (Bayer AG)
• Inventors: Rhinehart, Edward J., Cowan, Kevin P., Trocki, Mark, Tucker, Barry L.
• Primary Examiner(s): Miggins, Michael C
• Application Number:
  US15/032,425
• Publication Number:
  US 20160271330A1
• Time in Patent Office: 1,698 Days
• CPC Class Codes: A61M 2207/00 Methods of manufacture, assembly or production
• CPC Class Codes: A61M 2207/10 Device therefor
• CPC Class Codes: A61M 5/178 Syringes
• CPC Class Codes: A61M 5/31513 Piston constructions to improve sealing or sliding
• CPC Class Codes: B29B 11/14 characterised by structure or composition
• CPC Class Codes: B29C 2791/006 Using vacuum
• CPC Class Codes: B29C 2791/007 Using fluid under pressure
• CPC Class Codes: B29C 2949/0715 the preform having one end closed
• CPC Class Codes: B29C 2949/0722 at neck portion
• CPC Class Codes: B29C 2949/0725 at bottom portion
• CPC Class Codes: B29C 2949/0731 at neck portion
• CPC Class Codes: B29C 2949/077 characterised by the neck
• CPC Class Codes: B29C 2949/078 characterised by the bottom
• CPC Class Codes: B29C 2949/0794 Dispensing spout
• CPC Class Codes: B29C 2949/08 Preforms made of several individual parts, e.g. by welding or gluing parts together
• CPC Class Codes: B29C 2949/22 at neck portion
• CPC Class Codes: B29C 2949/24 at flange portion
• CPC Class Codes: B29C 2949/26 at body portion
• CPC Class Codes: B29C 2949/28 at bottom portion
• CPC Class Codes: B29C 49/071 Preforms or parisons characterised by their configuration, e.g. geometry, dimensions or physical properties
• CPC Class Codes: B29C 49/12 : Stretching rods
• CPC Class Codes: B29C 49/1212 : the stretching rod comprising at least one opening on the surface, e.g. through which compressed air is blown into the preform to expand the same
• CPC Class Codes: B29C 49/1215 : Geometry of the stretching rod, e.g. specific stretching rod end shape
• CPC Class Codes: B29C 49/18 : using several blowing steps B29C49/16 takes precedence
• CPC Class Codes: B29L 2031/753 : Medical equipment; Accessories therefor bloodbags, medical bags B29L2031/7148; artificial eyes B29L2011/0008
• CPC Class Codes: B29L 2031/7544 : Injection needles, syringes

Abstract

A syringe for use in pressurized injection of a fluid is provided herein. The syringe includes a syringe barrel comprising a polymeric material having undergone expansion by stretch blow molding and by compression molding of an inner diameter of the barrel with a core member. In certain configurations of the syringe barrel, the stretch blow molding is provided through a nozzle of the syringe. Similarly, according to a further embodiment, a syringe for use in pressurized injection of a fluid is provided. The syringe includes a syringe barrel comprising a polymeric material having undergone expansion by stretch blow molding and by shrinking an inner diameter of the syringe barrel about a core member.

Claims

1. A preform for stretch blow molding a syringe, the preform comprising:

a body having a distal end, an enclosed proximal end, and a circumferential wall therebetween and comprising a polymeric material suitable for stretch blow molding to form a syringe body; and

a nozzle comprising a first opening at the distal end of the body for inserting a stretch member for stretching the preform during a stretch blow molding process,

wherein the circumferential wall contains additional polymeric material arranged radially around the circumferential wall of the body toward the distal end,

wherein the additional polymeric material forms a barrel of the syringe.

2. The preform according to claim 1, further comprising a second opening at a proximal end of the body, wherein the second opening is formed after the stretch blow molding process.

3. The preform according to claim 1, further comprising a cap for sealably enclosing the first opening, the cap having a substantially conical shape and a luer tip.

4. The preform according to claim 3, wherein the cap further comprises at least one bayonet lock member around an outer circumference of the cap for releasable locking engagement with at least one notch or slot on a pressure jacket configured for attachment to a medical injector.

5. The preform according to claim 1, wherein the body is formed having the stretch member in an interior of the body, wherein the diameter of the stretch member is larger than the diameter of the first opening at the distal end of the body and wherein the stretch member has a substantially conical end for forming the distal end of the preform into a substantially conical shape during the stretch blow molding process.

6. The preform according to claim 5, wherein the stretch member is formed from a material selected from the group consisting of a second polymeric material having a glass transition temperature higher than the polymeric material of the preform, a composite material, and a metal material.

7. The preform according to claim 5, wherein the stretch member further comprises a lumen and a plurality of ports for injecting a gas into the interior of the body during the stretch blow molding process.

8. The preform according to claim 5, wherein the stretch member is removed through a second opening at a proximal end of the body, wherein the second opening is formed after the stretch blow molding process.

9. The preform according to claim 5, wherein the substantially conical shape formed at the distal end of the preform is configured to fit into a pressure jacket comprising a substantially conical distal end.

10. The preform according to claim 1, further comprising a second opening at a proximal end for receiving a stretch member, wherein the stretch member seals the first opening during a stretch blow molding process through the second opening.

11. The preform according to claim 10, wherein the proximal end of the preform comprises at least one retaining member for reversible engagement with a complementary locking member on a syringe port of a medical injector.

12. The preform according to claim 10, wherein an inner diameter of a surface of an inner wall is molded by insertion of a core member through the second opening.

13. The preform according to claim 12, wherein the core member is an expandable core comprising a flexible sheet coiled around an inner member, wherein the flexible sheet may transition between a first compressed state and a second expanded state.

14. The preform according to claim 12, wherein the core member is an expandable core comprising an expandable balloon for receiving a fluid.

15. The preform according to claim 12, wherein the surface of the inner wall is molded around the core member by application of vacuum or pressure and heat to shrink the inner walls of the preform against the core member.

16. The preform according to claim 15, wherein the core member is tapered from a proximal end to a distal end.