Systems and methods for ambulatory generation of nitric oxide
First Claim
1. A wearable nitric oxide generation system comprising:
- a housing configured to be wearable;
a reactant gas flow path located in the housing, the reactant gas flow path configured to provide release of a pressurized reactant gas at specific flow rates to one or more plasma chambers;
one or more electrodes located in the one or more plasma chambers configured to generate a product gas containing nitric oxide using a flow of the reactant gas through the one or more plasma chambers;
a controller configured to regulate the amount of nitric oxide generated in the reactant gas;
a disposable cartridge including one or more scavenger paths configured to remove NO2 from the product gas generated by the one or more plasma chambers, anda connector to deliver the product gas to a patient delivery device;
wherein the controller measures a resonant frequency of a high voltage circuit and controls a frequency and a duty cycle of an AC waveform to maximize excitation of the high voltage circuit; and
wherein the resonant frequency is determined throughout a service life of the system to accommodate changes in environmental conditions, system wear, and/or manufacturing variance.
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Accused Products
Abstract
Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.
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Citations
20 Claims
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1. A wearable nitric oxide generation system comprising:
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a housing configured to be wearable; a reactant gas flow path located in the housing, the reactant gas flow path configured to provide release of a pressurized reactant gas at specific flow rates to one or more plasma chambers; one or more electrodes located in the one or more plasma chambers configured to generate a product gas containing nitric oxide using a flow of the reactant gas through the one or more plasma chambers; a controller configured to regulate the amount of nitric oxide generated in the reactant gas; a disposable cartridge including one or more scavenger paths configured to remove NO2 from the product gas generated by the one or more plasma chambers, and a connector to deliver the product gas to a patient delivery device; wherein the controller measures a resonant frequency of a high voltage circuit and controls a frequency and a duty cycle of an AC waveform to maximize excitation of the high voltage circuit; and wherein the resonant frequency is determined throughout a service life of the system to accommodate changes in environmental conditions, system wear, and/or manufacturing variance. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A wearable nitric oxide generation system comprising:
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a housing configured to be wearable; a reactant gas flow path located in the housing, the reactant gas flow path configured to provide release of a pressurized reactant gas at specific flow rates to one or more plasma chambers; one or more electrodes located in the one or more plasma chambers configured to generate a product gas containing nitric oxide using a flow of the reactant gas through the one or more plasma chambers; a controller configured to regulate the amount of nitric oxide generated in the reactant gas; a disposable cartridge including one or more scavenger paths configured to remove NO2 from the product gas generated by the one or more plasma chambers; and a connector to deliver the product gas to a patient delivery device; wherein the controller measures a resonant frequency of a high voltage circuit and controls a frequency and a duty cycle of an AC waveform to maximize excitation of the high voltage circuit; and wherein the resonant frequency is automatically determined at a power-up of the system.
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19. A wearable nitric oxide generation system comprising:
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a housing configured to be wearable; a reactant gas flow path located in the housing, the reactant gas flow path configured to provide release of a pressurized reactant gas at specific flow rates to one or more plasma chambers; one or more electrodes located in the one or more plasma chambers configured to generate a product gas containing nitric oxide using a flow of the reactant gas through the one or more plasma chambers; a controller configured to regulate the amount of nitric oxide generated in the reactant gas; a disposable cartridge including one or more scavenger paths configured to remove NO2 from the product gas generated by the one or more plasma chambers; and a connector to deliver the product gas to a patient delivery device; wherein the controller measures a resonant frequency of a high voltage circuit and controls a frequency and a duty cycle of an AC waveform to maximize excitation of the high voltage circuit; and wherein the resonant frequency is automatically determined at the beginning of each patient treatment.
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20. A wearable nitric oxide generation system comprising:
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a housing configured to be wearable; a reactant gas flow path located in the housing, the reactant gas flow path configured to provide release of a pressurized reactant gas at specific flow rates to one or more plasma chambers; one or more electrodes located in the one or more plasma chambers configured to generate a product gas containing nitric oxide using a flow of the reactant gas through the one or more plasma chambers; a controller configured to regulate the amount of nitric oxide generated in the reactant gas; a disposable cartridge including one or more scavenger paths configured to remove NO2 from the product gas generated by the one or more plasma chambers; and a connector to deliver the product gas to a patient delivery device; wherein the controller measures a resonant frequency of a high voltage circuit and controls a frequency and a duty cycle of an AC waveform to maximize excitation of the high voltage circuit; and wherein the resonant frequency is stored in memory between uses so that a resonance search is not required at power-up of the system.
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Specification