Methods and systems for providing stimuli to the brain

• US 10,328,236 B2
• Filed: 11/23/2016
• Issued: 06/25/2019
• Est. Priority Date: 11/23/2015
• Status: Active Grant

• Current Assignee: Sana Health, Inc.
• Original Assignee: Sana Health, Inc.
• Inventors: Hanbury, Richard
• Primary Examiner(s): Dorna, Carrie R
• Application Number:
  US15/360,808
• Publication Number:
  US 20170143935A1
• Time in Patent Office: 944 Days
• CPC Class Codes: A61M 2021/0022 by the tactile sense, e.g. vibrations
• CPC Class Codes: A61M 2021/0027 by the hearing sense
• CPC Class Codes: A61M 2021/005 images, e.g. video
• CPC Class Codes: A61M 21/02 for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia for massage A61H; electrotherapy A61N, e.g. applying alternating or intermittent electric currents for producing anaesthesia A61N1/36021
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/505 Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: A61M 2209/088 on the body

Abstract

Visual and auditory stimuli are provided to a patient to treat various neurological disorders or conditions and/or to provide improved mental or physical performance. The visual and auditory stimuli are provided by a wearable headset or sleep mask that may be comfortably worn by a user, such as in bed to induce sleep. The wearable headset or sleep mask is operated by a personal computing device of the user, such as smartphone, having downloaded and active thereon a control application or app for the therapy. The wearable headset or sleep mask also concurrently provides tactile stimuli, and the tactile stimulus is provided from bone conduction transducers that concurrently provides the auditory stimuli.

Claims

1. A method of providing sensory stimulation to a user, the method comprising:

alternating sensory stimulation between

a first sensory stimulation including simultaneously providing a left visual stimulus pattern to a left eye of the user and a right auditory stimulus pattern to the right side of the head; and

a second sensory stimulation including simultaneously providing a right visual stimulus pattern to a right eye of the user and a left auditory stimulus pattern to the left side of the head of the user,

wherein one or more of the left auditory stimulus pattern or the right auditory stimulus pattern comprises a sequence of stimulus patterns including a first stimulus pattern having a first pulse frequency between 3.75 Hz and 4.25 Hz, a second stimulus pattern having a second pulse frequency between 1.25 Hz and 1.75 Hz, and a third stimulus pattern having a third pulse frequency between 0.25 Hz and 0.75 Hz.

2. The method of claim 1, further comprising:

periodically providing a sensory stimulation including simultaneously providing a left visual stimulus pattern to the left eye of the user, a right visual stimulus pattern to the right eye of the user, a left auditory stimulus pattern to the left side of the head, and a right auditory stimulus pattern to the right side of the head of the user.

3. The method of claim 2, further comprising:

alternating sensory stimulation between

a third sensory stimulation including simultaneously providing a left visual stimulus pattern to the left eye of the user and a left auditory stimulus pattern to the left side of the head, and

a fourth sensory stimulation including simultaneously providing a right visual stimulus pattern to the right eye of the user and a right auditory stimulus pattern to the right side of the head of the user.

4. The method of claim 3, further comprising:

alternating sensory stimulation between

a fifth sensory stimulation including simultaneously providing a left auditory stimulus pattern to the left side of the head and a right auditory stimulus pattern to the right side of the head, and

a sixth sensory stimulation including simultaneously providing a left visual stimulus pattern to the left eye of the user and a right visual stimulus pattern to the right eye of the user.

5. The method of claim 1, wherein the left auditory stimulus pattern comprises generating the left auditory stimulus pattern with a left speaker, and wherein generating the right auditory stimulus pattern comprises generating the right auditory stimulus pattern with a right speaker.

6. The method of claim 1, wherein the left auditory stimulus pattern comprises generating the left auditory stimulus pattern with a left bone conduction transducer of a headset, and wherein the right auditory stimulus pattern comprises generating the left auditory stimulus pattern with a left bone conduction transducer of the headset.

7. The method of claim 1, wherein one or more of the left or right auditory stimulus pattern includes an auditory frequency of from 240 Hz to 480 Hz.

8. The method of claim 1, wherein one or more of the left visual stimulus pattern or right visual stimulus pattern comprises repeatedly pulsing a light at one or more of a first frequency, a second frequency less than the first frequency, or a third frequency less than the first and second frequencies.

9. The method of claim 8, wherein the first frequency is between 3.75 Hz and 4.25 Hz, the second frequency is between 1.25 Hz and 1.75 Hz, and the third frequency is between 0.25 Hz and 0.75 Hz.

10. The method of claim 9, wherein repeatedly pulsing the light comprises pulsing the light for a predetermined time interval.

11. The method of claim 10, wherein the predetermined time interval is 25-45 seconds.

12. The method of claim 1, wherein the sequence of stimulus patterns each have a pulse frequency having a pulse period, where a portion of the pulse period includes a stimulus of an auditory frequency of from 240 Hz to 480 Hz.

13. The method of claim 12, wherein said portion of said pulse period is one half of the pulse period.

14. The method of claim 1, wherein said first stimulus pattern, said second stimulus pattern, or said third stimulus pattern stimulates for a predetermined time interval.

15. The method of claim 14, wherein the predetermined time interval is 25-35 seconds.

16. The method of claim 15, wherein the predetermined time interval is 30 seconds.

17. A method of treating a neurological disease or condition or providing performance enhancement using the method of claim 1.

18. The method of claim 17, where said neurological disease or condition comprises insomnia, post-traumatic stress disorder (PTSD) or brain injury.

19. The method of claim 17, where said treating provides increased alpha wave activity in the brain.

20. The method of claim 19, where said performance enhancement is providing sleep, the improvement of mental capabilities, or the improvement of physical capabilities.

21. An apparatus to provide stimulation to a user, the apparatus comprising:

a frame configured to be worn on a head of the user;

a controller programmed to generate a plurality of inputs including a left light source input, a right light source input, a left auditory source input, and a right auditory source input;

a left light source configured to generate a left visual stimulus pattern from said left light source input;

a right light source configured to generate a right visual stimulus pattern from said right light source input;

a left auditory source configured to generate a left auditory stimulus pattern from said left auditory source input; and

a right auditory source configured to generate a right auditory stimulus pattern from said right auditory source input;

where said controller is programmed to generate inputs which alternate between

a first input including simultaneously generating the left light source input and the right auditory source input, and

a second input including simultaneously generating the right light source input and the left auditory source input,

wherein one or more of the left auditory source input or the right auditory source input comprises a sequence of stimulus patterns including a first stimulus pattern having a first pulse frequency between 3.75 Hz and 4.25 Hz, a second stimulus pattern having a second pulse frequency between 1.25 Hz and 1.75 Hz, and a third stimulus pattern having a third pulse frequency between 0.25 Hz and 0.75 Hz.

22. The apparatus of claim 21, wherein one or more of the left auditory source or the right auditory source is a speaker.

23. The apparatus of claim 21, wherein one or more of the left auditory source or the right auditory source is a bone conduction transducer.

24. The apparatus of claim 21, wherein one or more of the left or right light source comprises a light-emitting diode (LED).

25. The apparatus of claim 24, wherein one or more of the left or right light source is configured to generate light at 550-610 nm.

26. The apparatus of claim 24, wherein one or more of the left or right light source is configured to generate light at 580 nm.

27. A method of treating a neurological disease or condition or providing performance enhancement, said method comprising:

providing a headset to be worn by a user;

providing sensory stimulation to the user from the headset, where said stimulation alternates between

a first sensory stimulation including simultaneously providing a left visual stimulus pattern to a left eye of the user and a right auditory stimulus pattern to the right side of the head, and

a second sensory stimulation including simultaneously providing a right visual stimulus pattern to a right eye of the user and a left auditory stimulus pattern to the left side of the head of the user,

wherein one or more of the left auditory stimulus pattern or the right auditory stimulus pattern comprises a sequence of stimulus patterns including a first stimulus pattern having a first pulse frequency between 3.75 Hz and 4.25 Hz, a second stimulus pattern having a second pulse frequency between 1.25 Hz and 1.75 Hz, and a third stimulus pattern having a third pulse frequency between 0.25 Hz and 0.75 Hz.

28. The method of claim 27, where said neurological disease or condition comprises insomnia, post-traumatic stress disorder (PTSD) or brain injury.

29. The method of claim 27, where said treating provides increased alpha wave activity in the brain.

30. The method of claim 27, where said performance enhancement is providing sleep, the improvement of mental capabilities, or the improvement of physical capabilities.