Fluid-based gating mechanism with tunable multiphase selectivity and antifouling behavior

• US 10,330,218 B2
• Filed: 02/09/2016
• Issued: 06/25/2019
• Est. Priority Date: 02/09/2015
• Status: Active Grant

• Current Assignee: President and Fellows of Harvard College (Harvard Corporation)
• Original Assignee: President and Fellows of Harvard College (Harvard Corporation)
• Inventors: Aizenberg, Joanna, Hou, Xu, Khan, Mughees, Tesler, Alexander
• Primary Examiner(s): Le, Minh Q
• Application Number:
  US15/549,991
• Publication Number:
  US 20180023728A1
• Time in Patent Office: 1,232 Days
• Field of Search: 13724715, 137833, 137827, 137828, 422507, 422522
• CPC Class Codes: F16K 2099/0084 Chemistry or biology, e.g. "lab-on-a-chip" technology
• CPC Class Codes: F16K 99/0017 Capillary or surface tension valves, e.g. using electro-wetting or electro-capillarity effects

Abstract

A gating mechanism that uses a capillary stabilized liquid as a reversible, reconfigurable gate that fills and seals pores in the closed state, and creates a non-fouling, liquid-lined pore in the open state is disclosed. Theoretical modeling and experiments demonstrate that for each transport substance, the gating threshold—the pressure needed to open the pores—can be rationally tuned over a wide pressure range. This enables realizing in one system differential response profiles for a variety of liquids and gases, even letting liquids flow through the pore while preventing gas from escaping. These capabilities allow dynamic modulation of gas-liquid sorting and to separate multi-phase mixtures, with the liquid lining ensuring sustained antifouling behavior. Because the liquid gating strategy enables efficient short-term and long-term operation and can be applied to a variety of pore structures and membrane materials, and to nano, micro as well as macroscale fluid systems, the gating systems is useful in a wide range of applications.

Claims

1. A gating membrane device comprising:

a membrane comprising a plurality of pores, wherein at least one pore of said plurality of pores has a continuous path that traverses a thickness of the membrane, the membrane positioned and arranged to permit a transport fluid to traverse the membrane thickness;

a wetting liquid filling the at least one pore of said plurality of pores,

wherein the wetting liquid partially displaces above a threshold pressure applied across said at least one pore to allow transport of the transport fluid through the membrane while contacting the wetting liquid,

wherein the wetting liquid is selected to be immiscible with the transport fluid, and

wherein the wetting liquid refills the at least one pore and gate transport of the transport fluid across the membrane below the threshold pressure.

2. The gating membrane device of claim 1, wherein the membrane is a polymer, a ceramic, a composite or a metal.

3. The gating membrane device of claim 1, further comprising an inlet and an outlet.

4. The gating membrane device of claim 1, wherein the membrane comprises a fluidic channel.

5. The gating membrane device of claim 4, wherein the fluidic channel is a nanofluidic or microfluidic or a macrofluidic channel.

6. The gating membrane device of claim 4, further comprising an inlet connected to the fluidic channel, an outlet connected to the fluidic channel, and a relief port.

7. The gating membrane device of claim 1, wherein said plurality of pores comprises an average pore size that ranges from 10 nm to 100 microns.

8. The gating membrane device of claim 1, wherein the wetting liquid is immiscible with the transport fluid.

9. The gating membrane device of claim 1, wherein the wetting liquid has a higher affinity to the porous membrane than the transport fluid.

10. The gating membrane device of claim 1, wherein the transport fluid comprises a mixture of different phases that traverse the membrane at different threshold pressures.

11. The gating membrane device of claim 1, wherein the gating membrane device is antifouling.

12. The gating membrane device of claim 1, wherein the transport fluid transports through the at least one pore without contacting the surfaces of the membrane defining the plurality of pores.

13. The gating membrane device of claim 1, wherein the wetting liquid covers at least a portion of the top and bottom surfaces of the membrane.

14. The gating membrane device of claim 1, wherein the wetting liquid is disposed within the membrane.

15. A method for transporting a fluid across a membrane comprising;

providing a membrane comprising a plurality of pores and a wetting liquid,

wherein at least one pore of said plurality of pores has a continuous path that traverses a thickness of the membrane,

wherein the membrane is positioned and arranged to permit a transport fluid to traverse the membrane thickness,

wherein the wetting liquid fills the at least one pore of said plurality of pores, and

wherein the wetting liquid is selected to be immiscible with the transport fluid;

applying a pressure above a threshold pressure across the membrane to displace the wetting liquid in said at least one pore and to transport the transport fluid through said membrane, wherein the transport fluid contacts the wetting liquid; and

lowering the pressure to a pressure below the threshold pressure to allow the wetting liquid to refill the at least one pore.

16. The method of claim 15, wherein the membrane is a polymer, a ceramic, a composite or a metal.

17. The method of claim 15, further comprising:

providing an inlet to apply said pressure and an outlet to receive the transport fluid which traversed across the membrane.

18. The method of claim 15, wherein the membrane comprises a fluidic channel.

19. The method of claim 18, wherein the fluidic channel is a nanofluidic, microfluidic or a macrofluidic channel.

20. The method of claim 18, further comprising:

providing an inlet to the fluidic channel;

providing an outlet to the fluidic channel, and

providing a relief port.

21. The method of claim 15, wherein said plurality of pores comprises an average pore size that ranges from 10 nm to 100 microns.

22. The method of claim 15, wherein the wetting liquid is immiscible with the transport fluid.

23. The method of claim 15, wherein the wetting liquid has a higher affinity to the porous membrane than the transport fluid.

24. The method of claim 15, wherein the transport fluid comprises a mixture of different phases that traverse the membrane at different threshold pressures.

25. The method of claim 15, wherein the membrane is antifouling.

26. The method of claim 15, wherein the transport fluid transports through the pore without contacting the surfaces of the membrane defining the plurality of pores.

27. The method of claim 15, wherein the wetting liquid covers at least a portion of the top and bottom surfaces of the membrane.

28. The method of claim 15, wherein the wetting liquid is disposed within the membrane.