Method and apparatus for calibration and testing of scientific measurement equipment
First Claim
1. A method of calibrating laboratory analyzer equipment comprising:
- using the laboratory analyzer equipment to generate sample results, the sample results including measurements of a single analyte from multiple persons;
determining a within-patient variation including;
determining average intra-patient variations of the sample results provided by the laboratory analyzer over a period of time;
determining an axis-intercept using a regression of the average intra-patient variations versus time between the sample results;
determining the within-patient variation as a function of the axis-intercept; and
calibrating the laboratory analyzer equipment as a function of the determined within-patient variation; and
using the calibrated laboratory analyzer equipment to generate further sample results of the single analyte.
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Abstract
Discussed herein are methods and apparatuses to produce profiles for scientific measurement equipment, and to use those profiles for various purposes in using, designing, calibrating and managing such equipment, such as to carry out critical laboratory testing. In this approach, either the analyzers'"'"' quality control data or serial patient data are numerically reduced to generate graphical precision profiles. Precision profiles for serial patient data show increased (im)precision vs time implying increased patient variation over increased time. Precision profiles for quality control data, according to one implementation, can demonstrate three different zones: 1) increased imprecision for quality control determinations that are close spaced (implies the discovery of an error condition and rapid reanalysis, 2) the usual imprecision and 3) a zone of increased imprecision which indicates either a need for a quality control analysis or re-calibration.
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Citations
19 Claims
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1. A method of calibrating laboratory analyzer equipment comprising:
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using the laboratory analyzer equipment to generate sample results, the sample results including measurements of a single analyte from multiple persons; determining a within-patient variation including; determining average intra-patient variations of the sample results provided by the laboratory analyzer over a period of time; determining an axis-intercept using a regression of the average intra-patient variations versus time between the sample results; determining the within-patient variation as a function of the axis-intercept; and calibrating the laboratory analyzer equipment as a function of the determined within-patient variation; and using the calibrated laboratory analyzer equipment to generate further sample results of the single analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A system comprising:
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laboratory analyzer equipment that performs measurements on biological samples, including one or more analytes of multiple persons, to generate sample results; a memory storing the sample results obtained from measuring the biological samples using the laboratory analyzer equipment; a display; a processor communicatively coupled to the memory, the display, and the laboratory analyzer equipment; the memory storing instructions, which when executed by the processor, cause the processor to; calculate a within-patient variation including; determining average intra-patient variations of the sample results obtained from the memory; determining an axis-intercept using a regression of the average intra-patient variations versus time between the sample results; determining the within-patient variation as a function of the axis-intercept; and determine calibration information as a function of the within-patient variation; and calibrate the laboratory analyzer equipment based on the calibration information; and wherein the laboratory analyzer equipment performs further measurements, after calibration, on the biological samples to generate calibrated sample results. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification