Oximeter probe with light wavelengths to avoid surgical dyes

• US 10,335,069 B2
• Filed: 12/21/2015
• Issued: 07/02/2019
• Est. Priority Date: 05/03/2012
• Status: Active Grant

• Current Assignee: ViOptix, Inc.
• Original Assignee: ViOptix, Inc.
• Inventors: Bechtel, Kate LeeAnn, Lloyd, Lester John
• Primary Examiner(s): Winakur, Eric F
• Assistant Examiner(s): Fardanesh, Marjan
• Application Number:
  US14/977,578
• Publication Number:
  US 20160100781A1
• Time in Patent Office: 1,289 Days
• Field of Search: None
• CPC Class Codes: A61B 2090/065 for measuring contact or contact pressure
• CPC Class Codes: A61B 2090/306 using optical fibres
• CPC Class Codes: A61B 2090/395 with marking agent for marking skin or other tissue
• CPC Class Codes: A61B 2560/0431 Portable apparatus, e.g. comprising a handle or case
• CPC Class Codes: A61B 2560/0475 Special features of memory means, e.g. removable memory cards
• CPC Class Codes: A61B 2562/0271 Thermal or temperature sensors
• CPC Class Codes: A61B 2562/166 the sensor is mounted on a specially adapted printed circuit board
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/72 Signal processing specially adapted for physiological signals or for diagnostic purposes character recognition, recognising digital ink, document-oriented image-based pattern recognition G06V30/00; recognition or understanding of postal images G06V30/424
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence
• CPC Class Codes: A61B 5/74 Details of notification to user or communication with user or patient indicating measured values G01D7/00; user input means input or output arrangements for computers G06F3/00
• CPC Class Codes: A61B 5/7405 using sound
• CPC Class Codes: A61B 5/742 : using visual displays A61B5/339 takes precedence
• CPC Class Codes: A61B 5/7475 : User input or interface means, e.g. keyboard, pointing device, joystick
• CPC Class Codes: A61B 90/11 : with guides for needles or instruments, e.g. arcuate slides or ball joints
• CPC Class Codes: A61B 90/39 : Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61M 35/003 : Portable hand-held applicators having means for dispensing or spreading integral media hand-held massage devices with liquid delivery A61H7/003

Abstract

A tissue oximetry device utilizes at least three or at least four different wavelengths of light for collection of reflectance data where the different wavelengths are longer than 730 nanometers. The three or four wavelengths are utilized to generate a range of reflectance data suited for accurate determination of oxygenated hemoglobin and deoxygenated hemoglobin concentrations. The relatively long wavelengths decrease optical interference from certain dyes, particularly methylene blue and PVPI, which may be present on tissue being analyzed for viability and further enhance the generation of accurate reflectance data. The wavelengths are 760 nanometers, 810 nanometers, and 850 nanometers, or 760 nanometers, 810 nanometers, 850 nanometers, and 900 nanometers.

Claims

1. A method comprising:

providing a sensor head for a tissue oximetry device comprising;

detectors arranged on the sensor head; and

first and second light source structures positioned in a line on the sensor head, wherein

the first source structure is configured to emit at least a first wavelength of light longer than about 730 nanometers,

the second source structure is configured to emit at least a second wavelength of light longer than about 730 nanometers,

a first detector of the detectors is a first distance from the first light source,

a second detector of the detectors is a second distance from the second light source,

a third detector of the detectors is a third distance from the first light source,

no detector is positioned between the first detector and the third detector, the line passes between the first detector and the third detector, the line is closer to the first detector than the third detector, and the first, second, and third detectors are not on the line,

the first distance and the second distance are equal, and

the first distance and the third distance are not equal; and

enclosing a processing module in a housing coupled to the sensor head, wherein the processing module is adapted for determining an oxygen saturation value for a tissue to be measured using the first wavelength of light from the first source structure and the second wavelength of light from the second source structure emitted into the tissue and corresponding reflected light received by at least two of the detectors.

2. The method of claim 1 wherein the determining an oxygen saturation value for a tissue comprises:

receiving digital reflectance data for the reflected light received by the at least two of the detectors;

calculating absorption coefficients using the digital reflectance data;

solving a set of reflection coefficient equations for the tissue to be measured using the absorption coefficients to determine concentration values of at least oxygenated hemoglobin and deoxygenated hemoglobin; and

determining an oxygen saturation value for the tissue using the concentration values of oxygenated hemoglobin and deoxygenated hemoglobin.

3. The method of claim 1 wherein the first wavelength of light is at least one of 760 nanometers, 810 nanometers, 850 nanometers, or 900 nanometers.

4. The method of claim 1 wherein the first wavelength of light is at least one of 760 nanometers, 810 nanometers, or 850 nanometers, and the second wavelength of light is at least one of 760 nanometers, 810 nanometers, 850 nanometers, or 900 nanometers.

5. The method of claim 1 wherein the first and second source structures are coupled via optical fibers to light emitting diodes, and the first, second, and third detector structures comprise photodetectors.

6. The method of claim 1 wherein the detectors are arranged in a circle.

7. The method of claim 1 wherein a fourth distance is between the first and second source structures, and the fourth distance is greater than the first distance, is greater than the second distance, and is greater than the third distance.

8. The method of claim 7 wherein the first detector is symmetrically positioned about a point on the first line with respect to the second detector.

9. The method of claim 8 wherein a fourth detector of the detectors is a fifth distance from the first light source, and the third detector is symmetrically positioned about the point on the first line with respect to the fourth detector.

10. The method of claim 1 wherein the first and second source structures are the only source structures on the sensor head.

11. The method of claim 1 wherein a second line between the first and second detectors does not pass through the first source structure and does not pass through the second source structure.

12. The method of claim 11 wherein a third line between the first and third detectors does not pass through the first source structure and does not pass through the second source structure.

13. The method of claim 12 wherein a fourth line between the second and third detectors does not pass through the first source structure and does not pass through the second source structure.

14. The method of claim 1 wherein a second line is between the first source structure and the first detector, a first angle is between the line and the second line, and the first angle is less than ninety degrees.

15. The method of claim 14 wherein a third line is between the first source structure and the second detector, a second angle is between the line and the third line, and the second angle is less than ninety degrees.

16. The method of claim 15 wherein a fourth line is between the first source structure and the third detector, a third angle is between the line and the fourth line, and the third angle is less than ninety degrees.

17. The method of claim 1 wherein the third detector is a Fourth distance from the second source structure,

a fourth detector of the detectors is a fifth distance from the second source structure,

a fifth detector of the detectors is a sixth distance from the second source structure,

the second, third, fourth, and fifth detectors are located on a same side of the line,

a second line is between the second source structure and the second detector,

a third line is between the second source structure and the third detector,

a fourth line is between the second source structure and the fourth detector,

a fifth line is between the second source structure and the fifth detector,

a first angle is between the line and the second line,

a second angle is between the line and the third line,

a third angle is between the line and the fourth line,

a fourth angle is between the line and the fifth line,

the first angle is larger than the second angle, is larger than the third angle, and is larger than the fourth angle,

the second angle is larger than the third angle and is larger than the fourth angle,

the third angle is larger than the fourth angle, and

the second, fourth, fifth, and sixth distances respectively increase as the first, second, third, and fourth angles respectively decrease.

18. A method comprising:

providing a sensor head for a tissue oximetry device comprising;

detectors arranged on the sensor head; and

first and second light source structures positioned in a line on the sensor head, wherein

the first source structure is configured to emit at least a first wavelength of light longer than about 730 nanometers, and the first wavelength of light is at least one of 760 nanometers, 810 nanometers, or 850 nanometers,

the second source structure is configured to emit at least a second wavelength of light longer than about 730 nanometers, and the second wavelength of light is at least one of 760 nanometers, 810 nanometers, or 850 nanometers,

a first detector of the detectors is a first distance from the first light source,

a second detector of the detectors is a second distance from the second light source,

a third detector of the detectors is a third distance from the first light source,

no detector is positioned between the first detector and the third detector, the line passes between the first detector and the third detector, and the line is closer to the first detector than the third detector,

the first distance and the second distance are equal,

the first distance and the third distance are not equal,

a fourth distance is between the first and second source structures,

the fourth distance is greater than the first distance, is greater than the second distance, and is greater than the third distance, and

the first and second source structures are coupled via optical fibers to light emitting diodes, and the first, second, and third detector structures comprise photodetectors; and

enclosing a processing module in a housing coupled to the sensor head, wherein the processing module is adapted for determining an oxygen saturation value for a tissue to be measured using the first wavelength of light from the first source structure and the second wavelength of light from the second source structure emitted into the tissue and corresponding reflected light received by at least two of the detectors,

the housing encloses a display, coupled to the processing module, and the display is visible from an exterior of the housing,

a memory coupled to the processing module, and

a battery coupled to and supplying power to the processing module and display.

19. The method of claim 18 wherein the determining an oxygen saturation value for a tissue comprises:

receiving digital reflectance data for the reflected light received by the at least two of the detectors;

calculating absorption coefficients using the digital reflectance data;

solving a set of reflection coefficient equations for the tissue to be measured using the absorption coefficients to determine concentration values of at least oxygenated hemoglobin and deoxygenated hemoglobin; and

determining an oxygen saturation value for the tissue using the concentration values of oxygenated hemoglobin and deoxygenated hemoglobin.

20. The method of claim 18 wherein the detectors are arranged in a circle.

21. The method of claim 18 wherein when the sensor head is placed against the tissue to be measured, the display of the tissue oximetry device faces a user.

22. The method of claim 18 wherein a first light emitting diode is coupled via a first optical fiber to the first source structure, a second light emitting diode is coupled via a second optical fiber to the first source structure, and the first light emitting diode can emit the first wavelength of light of at least two different wavelengths.

23. The method of claim 18 wherein a first light emitting diode is coupled via a first optical fiber to the first source structure, a second light emitting diode is coupled via a second optical fiber to the first source structure, and the first light emitting diode can emit the first wavelength of light of at least four different wavelengths and the at least four wavelengths are longer than wavelengths of primary absorption peaks of methylene blue.

24. The method of claim 18 wherein the first, second, and third detectors are not on the line.

25. The method of claim 18 wherein the first detector is symmetrically positioned about a point on the line with respect to the second detector.

26. The method of claim 25 wherein a fourth detector of the detectors is a fourth distance from the first light source, and the third detector is symmetrically positioned about the point on the line with respect to the fourth detector.

27. The method of claim 18 wherein the first and second source structures are the only source structures on the sensor head.

28. The method of claim 18 wherein a second line between the first and second detectors does not pass through the first source structure and does not pass through the second source structure.

29. The method of claim 28 wherein a third line between the first and third detectors does not pass through the first source structure and does not pass through the second source structure.

30. The method of claim 29 wherein a fourth line between the second and third detectors does not pass through the first source structure and does not pass through the second source structure.

31. The method of claim 18 wherein a second line is between the first source structure and the first detector, a first angle is between the line and the second line, and the first angle is less than ninety degrees.

32. The method of claim 31 wherein a third line is between the first source structure and the second detector, a second angle is between the line and the third line, and the second angle is less than ninety degrees.

33. The method of claim 32 wherein a fourth line is between the first source structure and the third detector, a third angle is between the line and the fourth line, and the third angle is less than ninety degrees.

34. The method of claim 18 wherein the third detector is a fourth distance from the second source structure,

a fourth detector is a fifth distance from the second source structure,

a fifth detector is a sixth distance from the second source structure,

the second, third, fourth, and fifth detectors are located on a same side of the line,

a second line is between the second source structure and the second detector,

a third line is between the second source structure and the third detector,

a fourth line is between the second source structure and the fourth detector,

a fifth line is between the second source structure and the fifth detector,

a first angle is between the line and the second line,

a second angle is between the line and the third line,

a third angle is between the line and the fourth line,

a fourth angle is between the line and the fifth line,

the first angle is larger than the second angle, is larger than the third angle, and is larger than the fourth angle,

the second angle is larger than the third angle and is larger than the fourth angle,

the third angle is larger than the fourth angle, and

the second, fourth, fifth, and sixth distances respectively increase as the first, second, third, and fourth angles respectively decrease.

35. The method of claim 18 wherein the detectors are not arranged in a circle.

36. A method comprising:

providing a sensor head for a tissue oximetry device comprising;

a plurality of detector structures arranged on the sensor head; and

first and second source structures positioned in a, first line on the sensor head, wherein the first source structure is configured to emit at least a first wavelength of light longer than about 730 nanometers,

the second source structure is configured, to emit at least a second wavelength of light longer than about 730 nanometers,

a first detector of the plurality of detectors is a first distance from the first light source,

a second detector of the plurality of detectors is a second distance from the second light source,

a third detector of the plurality of detectors is a third distance from the first light source,

the first line is between the first detector and the third detector, and the first line is closer to the first detector than the third detector,

the first and second distances are equal,

the first and third distances are not equal,

a second line between the first and second detectors does not pass through the first source structure and does not pass through the second source structure,

a third line between the first and third detectors does not pass through the first source structure and does not pass through the second source structure, and

a fourth line between the second and third detectors does not pass through the first source structure and does not pass through the second source structure; and

enclosing a processing module in a housing coupled to the sensor head, wherein the processing module is adapted for determining an oxygen saturation value for a tissue to be measured using the first wavelength of light from the first source structure and the second wavelength of light from the second source structure emitted into the tissue and corresponding reflected light received by at least two of the detectors.

37. The method of claim 36 wherein the determining an oxygen saturation value for a tissue comprises:

receiving digital reflectance data for the reflected light received by the at least two of the detector structures;

calculating absorption coefficients using the digital reflectance data;

solving a set of reflection coefficient equations for the tissue to be measured using the absorption coefficients to determine concentration values of at least oxygenated hemoglobin and deoxygenated hemoglobin; and

determining an oxygen saturation value for the tissue using the concentration values of oxygenated hemoglobin and deoxygenated hemoglobin.

38. The method of claim 36 wherein the detector structures are arranged in a circle.

39. The method of claim 36 wherein the detector structures are not arranged in a circle.

40. The method of claim 36 wherein when the sensor head is placed against the tissue to be measured, a display of the tissue oximetry device faces a user.

41. The method of claim 36 wherein a first light emitting diode is coupled via a first optical fiber to the first source structure, a second light emitting diode is coupled via a second optical fiber to the second source structure, and the first light emitting diode can emit the first wavelength of light of at least two different wavelengths.

42. The method of claim 36 wherein a first light emitting diode is coupled via a first optical fiber to the first source structure, a second light emitting diode is coupled via a second optical fiber to the second source structure, and the first light emitting diode can emit the first wavelength of light of at least four different wavelengths and the at least four wavelengths are longer than wavelengths of primary absorption peaks of methylene blue.

43. The method of claim 36 wherein the first, second, and third detector structures are not on the first line.

44. The method of claim 36 wherein a fourth distance is between the first and second source structures, and the fourth distance is greater than the first distance, is greater than the second distance, and is greater than the third distance.

45. The method of claim 44 wherein the first detector structure is symmetrically positioned about a point on the first line with respect to the second detector structure.

46. The method of claim 45 wherein a fourth detector structure of the plurality of detector structures is a fourth distance from the first source structure, and the third detector structure is symmetrically positioned about the point on the first line with respect to the fourth detector structure.

47. The method of claim 36 wherein the first and second source structures are the only source structures on the sensor head.

48. The method of claim 36 wherein a second line between the first and second detector structures does not pass through the first source structure and does not pass through the second source structure.

49. The method of claim 48 wherein a third line between the first and third detector structures does not pass through the first source structure and does not pass through the second source structure.

50. The method of claim 49 wherein a fourth line between the second and third detector structures does not pass through the first source structure and does not pass through the second source structure.

51. The method of claim 36 wherein a second line is between the first source structure and the first detector structure, a first angle is between the first line and the second line, and the first angle is less than ninety degrees.

52. The method of claim 51 wherein a third line is between the first source structure and the second detector structure, a second angle is between the first line and the third line, and the second angle is less than ninety degrees.

53. The method of claim 52 wherein a fourth line is between the first source structure and the third detector structure, a third angle is between the first line and the fourth line, and the third angle is less than ninety degrees.

54. The method of claim 36 wherein the third detector is a fourth distance from the second source structure,

a fourth detector structure of the plurality of detector structures is a fifth distance from the second source structure,

a fifth detector structure of the plurality of detector structures is a sixth distance from the second source structure,

the second, third, fourth, and fifth detectors are located on a same side of the first line,

a second line is between the second source structure and the second detector,

a third line is between the second source structure and the third detector,

a fourth line is between the second source structure and the fourth detector,

a fifth line is between the second source structure and the fifth detector,

a first angle is between the first line and the second line,

a second angle is between the first line and the third line,

a third angle is between the first line and the fourth line,

a fourth angle is between the first line and the fifth line,

the first angle is larger than the second angle, is larger than the third angle, and is larger than the fourth angle,

the second angle is larger than the third angle and is larger than the fourth angle,

the third angle is larger than the fourth angle, and

the second, fourth, fifth, and sixth distances respectively increase as the first, second, third, and fourth angles respectively decrease.