Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
First Claim
1. A method for delivering growth hormone into a wall of an intestine, the method comprising:
- swallowing a drug delivery device comprising a capsule, an actuator having a first configuration and a second configuration and a growth hormone preparation operably coupled to the actuator, the growth hormone preparation comprising a therapeutically effective dose of growth hormone, the preparation being contained within the capsule in the first configuration and advanced out of the capsule and into the intestinal wall in the second configuration; and
actuating the actuator responsive to a condition in the intestine to deliver the growth hormone preparation into the wall of the small intestine.
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Accused Products
Abstract
Embodiment of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
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Citations
27 Claims
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1. A method for delivering growth hormone into a wall of an intestine, the method comprising:
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swallowing a drug delivery device comprising a capsule, an actuator having a first configuration and a second configuration and a growth hormone preparation operably coupled to the actuator, the growth hormone preparation comprising a therapeutically effective dose of growth hormone, the preparation being contained within the capsule in the first configuration and advanced out of the capsule and into the intestinal wall in the second configuration; and actuating the actuator responsive to a condition in the intestine to deliver the growth hormone preparation into the wall of the small intestine. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method for treating a growth hormone deficiency in a patient, the method comprising:
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swallowing a drug delivery device comprising a capsule, an actuator having a first configuration and a second configuration and a growth hormone preparation operably coupled to the actuator, the growth hormone preparation comprising a therapeutically effective dose of growth hormone, the preparation being contained within the capsule in the first configuration and advanced out of the capsule and into the intestinal wall in the second configuration; actuating the actuator responsive to a condition in the intestine to deliver the growth hormone preparation into the wall of the small intestine; and utilizing the released growth hormone to treat the condition associated with growth hormone deficiency. - View Dependent Claims (24, 25, 26)
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27. A method for delivering growth hormone into a wall of an intestine, the method comprising:
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swallowing a drug delivery device comprising a capsule, an actuator having a first configuration and a second configuration and a growth hormone preparation comprising a therapeutically effective dose of growth hormone, the grown hormone preparation positioned to be moved be actuation of the actuator, the preparation being contained within the capsule in the first configuration and advanced out of the capsule and into the intestinal wall in the second configuration; and actuating the actuator responsive to a condition in the intestine to deliver the growth hormone preparation into the wall of the small intestine.
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Specification