Methods of treatment

• US 10,335,558 B2
• Filed: 06/02/2014
• Issued: 07/02/2019
• Est. Priority Date: 06/07/2011
• Status: Active Grant

• Current Assignee: Parion Sciences, Inc.
• Original Assignee: Parion Sciences, Inc.
• Inventors: Boucher, Richard C., Johnson, Michael Ross, Thelin, William R., Button, Brian, Navratil, Tomas
• Primary Examiner(s): Douglas, Steven O
• Application Number:
  US14/293,255
• Publication Number:
  US 20150101597A1
• Time in Patent Office: 1,856 Days
• CPC Class Codes: A61K 9/0075 for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
• CPC Class Codes: A61K 9/0078 for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
• CPC Class Codes: A61M 11/002 by flow deviation causing inertial separation of transported particles
• CPC Class Codes: A61M 11/003 by passing the aerosol trough sieves or filters
• CPC Class Codes: A61M 11/005 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 11/06 of the injector type
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 15/0086 Inhalation chambers
• CPC Class Codes: A61M 16/0666 Nasal cannulas or tubing devices for improving normal breathing through the nose A61F5/08; nose filters A62B23/06; outside holding devices A61M25/02
• CPC Class Codes: A61M 16/12 by mixing different gases
• CPC Class Codes: A61M 16/14 by mixing different fluids, one of them being in a liquid phase
• CPC Class Codes: A61M 16/16 Devices to humidify the respiration air A61M16/1045 takes precedence
• CPC Class Codes: A61M 2202/0275 Nitric oxide [NO]
• CPC Class Codes: A61M 2206/14 Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws
• CPC Class Codes: A61M 2206/16 Rotating swirling helical flow, e.g. by tangential inflows
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/02 Nasal agents, e.g. decongestants
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 11/08 Bronchodilators
• CPC Class Codes: A61P 11/12 Mucolytics
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/04 : Antibacterial agents
• CPC Class Codes: A61P 31/10 : Antimycotics
• CPC Class Codes: A61P 31/12 : Antivirals
• CPC Class Codes: A61P 31/14 : for RNA viruses
• CPC Class Codes: A61P 31/22 : for herpes viruses
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Embodiments disclosed herein are directed to methods, compositions and apparatus for administering active agents to the lungs of a subject.

Claims

1. An apparatus comprising:

an entrainment chamber including a gas inlet and a first aerosol outlet, the gas inlet configured to fluidically couple a gas source to the entrainment chamber to produce an entrained aerosol flow at the first aerosol outlet;

a nozzle in fluidic communication with the first aerosol outlet of the entrainment chamber, the nozzle configured to alter the velocity of the entrained aerosol flow; and

a particle selection chamber defining a fluid pathway, the particle selection chamber including a second aerosol outlet and configured to produce an outlet aerosol flow at the second aerosol outlet, the particle selection chamber further configured to receive the entrained aerosol flow from the nozzle and into the fluid pathway, at least a portion of the fluid pathway including a tortuous path configured to remove aerosol particles in the entrained aerosol flow below a predetermined diameter such that a volumetric median diameter (VMD) of the outlet aerosol flow is less than a VMD of the entrained aerosol flow.

2. The apparatus of claim 1, wherein the nozzle is configured to increase the velocity of the entrained aerosol flow.

3. The apparatus of claim 1, wherein the nozzle includes a first end defining an inlet opening having a first cross sectional area, the inlet opening configured to receive the entrained aerosol flow from the aerosol outlet, the nozzle further including a second end defining an outlet opening having a second cross sectional area that is less than the first cross sectional area, the second end in fluid communication with the particle selection chamber.

4. The apparatus of claim 1, wherein the particle selection chamber includes a barrier configured to reduce an amount of the aerosol particles in the entrained aerosol flow that are greater than a predetermined diameter.

5. The apparatus of claim 4, wherein the barrier is selected from one or more of the following:

a baffle, a particle filter, a curved barrier, a spiral barrier, and an elutriator.

6. The apparatus of claim 1, wherein the fluid pathway is a nonlinear pathway.

7. The apparatus of claim 1, wherein the aerosol inlet is configured to be coupled to a nebulizer.

8. The apparatus of claim 1, wherein the second aerosol outlet is configured to be connected to a nasal cannula.

9. The apparatus of claim 1, wherein the entrainment chamber defines a rainout outlet port.

10. The apparatus of claim 1, further comprising:

a container fluidically coupled to the entrainment chamber, the container containing an active agent, the active agent selected from the group consisting of osmolytes, secretogogues, mucus modifying agents (mucolytics), type II antibiotics, and combinations thereof.