Universal methylation profiling methods
First Claim
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1. A method of determining whether a cytosine present at a predefined position within a single strand of a double-stranded DNA of known sequence is non-methylated comprising:
- a) contacting the double-stranded DNA with a CpG methyltransferase and an S-adenosylmethionine analog having the structure;
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Abstract
The present invention provides a method of determining whether cytosine residues present at a predetermined positions within a single strand of a double stranded DNA of known sequence are methylated as well as compounds for carrying out this method.
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Citations
14 Claims
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1. A method of determining whether a cytosine present at a predefined position within a single strand of a double-stranded DNA of known sequence is non-methylated comprising:
a) contacting the double-stranded DNA with a CpG methyltransferase and an S-adenosylmethionine analog having the structure; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of determining whether a cytosine present at a predefined position within a single strand of a double-stranded DNA of known sequence is non-methylated comprising:
a) contacting the double-stranded DNA with a CpG methyltransferase and an S-adenosylmethionine analog having the structure; - View Dependent Claims (14)
Specification