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Detection of progressive central hypovolemia

  • US 10,342,437 B2
  • Filed: 11/27/2013
  • Issued: 07/09/2019
  • Est. Priority Date: 08/08/2006
  • Status: Active Grant
First Claim
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1. A method of early detection of total blood volume changes in an animate being by time based, real time monitoring of arterial pressure pulse waveforms as an immediate indicator of blood volume change comprising the steps of:

  • positioning a noninvasive sensor at a single arterial pulse detection site of said animate being;

    recording, with said sensor, arterial pressure pulse waveforms generated by said animate being;

    gathering, in real time, with a microprocessor, arterial pressure pulse waveform data from said sensor;

    storing said arterial pressure pulse waveform data on a non-transitory computer readable medium as said data is received from said sensor;

    running a pulse decomposition analysis algorithm, with said microprocessor, as said data is received from said sensor, said pulse decomposition algorithm capable of monitoring arrival time differences of pulses within said arterial pressure pulse waveform, in order to;

    a) locate within each of said arterial pressure pulse waveforms a primary constituent systolic pulse, renal constituent reflection pulse, and iliac reflection constituent pulse,b) extract from each of said primary constituent systolic pulse, and said iliac reflection constituent pulse a primary constituent systolic peak, and iliac reflection constituent peak, respectively, andc) identify in real time a millisecond time of arrival of said primary systolic constituent peak and said iliac reflection constituent peak within each of said arterial pressure pulse waveforms recorded;

    calculating in real time, with said microprocessor, a millisecond time difference between said arrival time of said primary systolic constituent peak and said arrival time of said constituent iliac reflection peak,generating, with said microprocessor, real time arterial pressure pulse time difference data based on said time difference between arrival time of said primary systolic constituent peak and arrival time of said constituent iliac reflection peak;

    storing on a non-transitory computer readable medium said arterial pulse time difference data,comparing in real time, with said microprocessor, said arterial pressure pulse time difference data generated with previously stored arterial pressure pulse time difference data to monitor change in said arterial pulse time difference data;

    monitoring, with said microprocessor, said arterial pressure pulse time difference of each and arterial pressure pulse recording in real time over a predetermined period of time, anddisplaying said time difference data for observation;

    wherein said arterial pressure pulse time difference data indicates a real-time time difference between said arrival time of said primary systolic constituent peak and said arrival time of said constituent iliac reflection peak of each of said arterial pressure pulse waveforms read, and wherein said arterial pressure pulse time difference directly corresponds to changes in blood volume in said animate being that predict in real time the onset of hypovolemia or hypervolemia.

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