Method and system for monitoring the lung function of a patient

• US 10,342,457 B2
• Filed: 05/28/2013
• Issued: 07/09/2019
• Est. Priority Date: 06/08/2012
• Status: Active Grant

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Spencer, Timothy, Dyche, Anthony, Rabbetts, Ian Philip
• Primary Examiner(s): Weare, Meredith
• Application Number:
  US14/399,314
• Publication Number:
  US 20150099994A1
• Time in Patent Office: 2,233 Days
• CPC Class Codes: A61B 5/085 Measuring impedance of respiratory organs or lung elasticity
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices
• CPC Class Codes: A61B 5/4842 Monitoring progression or stage of a disease
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards

Abstract

There is provided a method of monitoring the lung function of a patient, the method comprising determining one or both of an inhalation time and a rest time for a patient that is using a respiratory apparatus, the one or both of an inhalation time and a rest time for the patient being determined from measurements obtained from the respiratory apparatus, wherein the inhalation time is the amount of time for which the patient inhales through the respiratory apparatus, and the rest time is the amount of time between the end of an exhalation and the start of the next inhalation; and analyzing the determined one or both of the inhalation time and rest time to determine an indication of the lung function of the patient.

Claims

1. A method of detecting a pulmonary exacerbation in a patient, the method comprising:

measuring, with a respiratory apparatus configured to deliver medication to a patient, a first inhalation time and a first rest time for the patient during a first medication treatment, wherein inhalation time is the amount of time for which the patient inhales through the respiratory apparatus, and rest time is the amount of time between the end of an exhalation and the start of a next inhalation during a medication treatment;

determining, with the respiratory apparatus, a first lung function index based on the first inhalation time and the first rest time, wherein the first lung function index is a ratio of the first inhalation time to the first rest time;

measuring, with the respiratory apparatus, a second inhalation time and a second rest time for the patient during a second medication treatment;

determining, with the respiratory apparatus, a second lung function index based on the second inhalation time and the second rest time, wherein the second lung function index is a ratio of the second inhalation time to the second rest time;

calculating, with the respiratory apparatus, a change in a lung function of the patient based on a comparison between the second lung function index and the first lung function index;

generating, with the respiratory apparatus, an indication that the patient is experiencing a pulmonary exacerbation responsive to the change in the lung function satisfying a change threshold; and

presenting, on a display of the respiratory apparatus, the indication that the patient is experiencing a pulmonary exacerbation.

2. A method as claimed in claim 1, further comprising sending, with the respiratory apparatus, the indication that the patient is experiencing a pulmonary exacerbation to a remote computer system over the Internet.

3. A method as claimed in claim 1, wherein the method further comprises:

determining a target inhalation time, wherein the patient is required to inhale through the respiratory apparatus for the target inhalation time.

4. A method as claimed in claim 3, wherein the method further comprises increasing the target inhalation time for a subsequent inhalation by the patient responsive to the patient inhaling for a time equal to or exceeding the target inhalation time.

5. A method as claimed in claim 1, wherein the inhalation time is one or more of:

the amount of time for which the patient inhales through the respiratory apparatus in a single breath, the average amount of time for which the patient inhales through the respiratory apparatus over a plurality of breaths, and the total amount of time that the patient is inhaling through the respiratory apparatus over a plurality of breaths.

6. A method as claimed in claim 1, wherein the rest time is one or more of:

the amount of time between the end of an exhalation and the start of the next inhalation for a single breath, the average amount of time between the end of an exhalation and the start of the next inhalation over a plurality of breaths, and the total amount of time between the end of an exhalation and the start of the next inhalation over a plurality of breaths.

7. A method as claimed in claim 1, wherein the method further comprises determining a rate of change in the lung function of the patient.

8. A method as claimed in claim 7, wherein the method further comprises comparing the determined rate of change in the lung function of the patient to one or more rate of change thresholds.

9. A computer-readable non-transitory storage medium containing instructions that when executed by one or more processors of a respiratory apparatus configured for delivering medication to a patient and detecting a pulmonary exacerbation in a patient, cause the one or more processors to perform the steps of:

measuring a first inhalation time and a first rest time for the a patient during a first time period in which the respiratory apparatus is delivering a first medication treatment to the patient, wherein inhalation time is the amount of time for which the patient inhales through the respiratory apparatus, and rest time is the amount of time between the end of an exhalation and the start of a next inhalation during a medication treatment;

determining a first lung function index based on the first inhalation time and the first rest time, wherein the first lung function index is a ratio of the first inhalation time to the first rest time;

measuring a second inhalation time and a second rest time for the patient during a second time period in which the respiratory apparatus is delivering a second medication treatment to the patient;

determining a second lung function index based on the second inhalation time and the second rest time, wherein the second lung function index is a ratio of the second inhalation time to the second rest time;

calculating a change in a lung function of the patient based on a comparison between the second lung function index and the first lung function index;

generating an indication that the patient is experiencing a pulmonary exacerbation responsive to the change in the lung function satisfying a change threshold; and

presenting, on a display of the respiratory apparatus, the indication that the patient is experiencing a pulmonary exacerbation.

10. A respiratory apparatus for delivering medication to a patient and detecting a pulmonary exacerbation in the patient, the respiratory apparatus configured to:

deliver medication to a patient;

measure an a first inhalation time and a first rest time for the patient during a first time period in which the respiratory apparatus is delivering a first medication treatment to the patient, wherein inhalation time is the amount of time for which the patient inhales through the respiratory apparatus, and rest time is the amount of time between the end of an exhalation and the start of a next inhalation during a medication treatment;

determine a first lung function index based on the first inhalation time and the first rest time, wherein the first lung function index is a ratio of the first inhalation time to the first rest time;

measure a second inhalation time and a second rest time for the patient during a second time period in which the respiratory apparatus is delivering a second medication treatment to the patient;

determine a second lung function index based on the second inhalation time and the second rest time, wherein the second lung function index is a ratio of the second inhalation time to the second rest time;

calculate a change in a lung function of the patient based on a comparison between the second lung function index and the first lung function index;

generate an indication that the patient is experiencing a pulmonary exacerbation responsive to the change in the lung function satisfying a change threshold; and

present, on a display of the respiratory apparatus, the indication that the patient is experiencing a pulmonary exacerbation.