Regional saturation system with ensemble averaging

• US 10,342,466 B2
• Filed: 03/11/2016
• Issued: 07/09/2019
• Est. Priority Date: 03/24/2015
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Lisogurski, Daniel
• Primary Examiner(s): Winakur, Eric F
• Assistant Examiner(s): Fardanesh, Marjan
• Application Number:
  US15/067,769
• Publication Number:
  US 20160278674A1
• Time in Patent Office: 1,215 Days
• Field of Search: None
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence
• CPC Class Codes: A61B 5/7289 Retrospective gating, i.e. associating measured signals or images with a physiological event after the actual measurement or image acquisition, e.g. by simultaneously recording an additional physiological signal during the measurement or image acquisition

Abstract

A method may include receiving, at a processor, a first electromagnetic radiation signal and a second electromagnetic radiation signal from a regional oximetry sensor having two or more detectors and two or more emitters. The method may also include receiving, at the processor, a trigger signal that has a frequency corresponding to a periodic physical activity of a patient. Additionally, the method may include generating, via the processor, one or more ensemble averaged signals based at least in part on the first and second electromagnetic radiation signals and the trigger signal. Further, the method may include calculating, via the processor, a regional oxygen saturation value based at least in part on the one or more ensemble averaged signals and displaying, via a display, the regional oxygen saturation value.

Claims

1. A method of ensemble averaging signals in a regional oximeter, comprising:

receiving, at a processor, a first electromagnetic radiation signal and a second electromagnetic radiation signal from a regional oximetry sensor having two or more detectors and two or more emitters, wherein a first detector of the two or more detectors is spaced apart from the two or more emitters a first distance and a second detector of the two or more detectors is spaced apart from the two or more emitters a second distance that is greater than the first distance, wherein the first electromagnetic radiation signal is recieved by the first detector of the two or more detectors and the second electromagnetic radiation signal is received by the second detector of the two or more detectors, and wherein the first electromagnetic radiation signal and the second electromagnetic radiation signal each comprise arterial pulses and venous pulses;

receiving, at the processor, a trigger signal, wherein the trigger signal has a frequency corresponding to a periodic physical activity of a patient and wherein the trigger signal is determined from the first electromagnetic radiation signal;

generating, via the processor, one or more ensemble averaged signals based at least in part on the first and second electromagnetic radiation signals and the trigger signal;

calculating, via the processor, a regional oxygen saturation value based at least in part on the one or more ensemble averaged signals, wherein the regional oxygen saturation value corresponds to a blood oxygen saturation within venous, arterial, and capillary systems of a region of a patient'"'"'s tissue; and

displaying, via a display, the regional oxygen saturation value.

2. The method of claim 1, comprising:

subtracting, via the processor, the first electromagnetic radiation signal from the second electromagnetic radiation signal to generate a difference electromagnetic radiation signal; and

ensemble averaging, via the processor, the difference electromagnetic radiation signal utilizing the trigger signal to generate the one or more ensemble averaged signals.

3. The method of claim 1, comprising:

ensemble averaging, via the processor, the first electromagnetic radiation signal utilizing the trigger signal to generate a first ensemble averaged signal of the one or more ensemble averaged signals and ensemble averaging, via the processor, the second electromagnetic radiation signal utilizing the trigger signal to generate a second ensemble averaged signal of the one or more ensemble averaged signals;

subtracting, via the processor, the first ensemble averaged signal from the second ensemble averaged signal to generate a difference ensemble averaged signal; and

calculating, via the processor, the regional oxygen saturation value based at least in part on the difference ensemble averaged signal.

4. The method of claim 3, comprising:

receiving, at a processor, a third electromagnetic radiation signal and a fourth electromagnetic radiation signal, wherein the first and second electromagnetic radiation signals are based on light emitted at a first wavelength, and the third and fourth electromagnetic radiation signals are based on light emitted at a second different wavelength, wherein the third electromagnetic radiation signal is received at the first detector of the two or more detectors and the fourth electromagnetic radiation signal is received at the second detector of the two or more detectors;

ensemble averaging, via the processor, the third electromagnetic radiation signal utilizing the trigger signal to generate a third ensemble averaged signal of the one or more ensemble averaged signals and ensemble averaging, via the processor, the fourth electromagnetic radiation signal utilizing the trigger signal to generate a fourth ensemble averaged signal of the one or more ensemble averaged signals; and

subtracting, via the processor, the third ensemble averaged signal from the fourth ensemble averaged signal to generate a second difference ensemble averaged signal;

wherein calculating the regional oxygen saturation value is based at least in part on both difference ensemble averaged signals.

5. The method of claim 1, comprising:

identifying, via the processor, one or more features in the one or more ensemble averaged signals, wherein the one or more features comprise a pulse amplitude, a pulse shape, a pulse period, a dicrotic notch, or any combination thereof; and

determining, via the processor, whether the regional oximetry sensor is disposed on the patient based at least in part upon an analysis of the one or more features; and

providing, via the processor, a user-perceivable indication in response to a determination that the regional oximetry sensor is not disposed on the patient.

6. The method of claim 5, comprising:

calculating, via the processor, the regional oxygen saturation value based at least in part upon the one or more features.

7. The method of claim 1, wherein the frequency of the trigger signal corresponds to a cardiac cycle of the patient, and wherein the regional oxygen saturation value comprises a regional arterial oxygen saturation value.

8. The method of claim 1, comprising:

receiving, at the processor, a second trigger signal that has a frequency corresponding to the cardiac cycle of the patient;

determining, via the processor, whether the trigger signal from the first detector includes one or more identifiable arterial pulses; and

generating, via the processor, the one or more ensemble averaged signals based at least in part on the first and second electromagnetic radiation signals and the second trigger signal in response to a determination that the trigger signal from the first detector does not include one or more identifiable arterial pulses.

9. The method of claim 1, wherein the frequency of the trigger signal corresponds to a respiratory cycle of the patient, and wherein the regional oxygen saturation value comprises a regional venous oxygen saturation value.

10. The method of claim 1, comprising:

defining, via the processor, one or more arterial pulses in the one or more ensemble averaged signals.

11. The method of claim 10, wherein the frequency of the trigger signal corresponds to a cardiac cycle of the patient.

12. The method of claim 11, further comprising identifying a pulse rate based on the one or more arterial pulses in the one or more ensemble averaged signals.

13. The method of claim 11, further comprising identifying a respiration rate based on the one or more arterial pulses in the one or more ensemble averaged signals.

14. The method of claim 10, wherein the frequency of the trigger signal corresponds to a respiratory cycle of the patient.

15. A patient monitor, comprising:

a memory encoding one or more processor-executable routines; and

a processor configured to access and execute the one or more processor-executable routines encoded by the memory, wherein the one or more processor-executable routines, when executed, cause the processor to;

receive a first electromagnetic radiation signal and a second electromagnetic radiation signal from a regional oximetry sensor having two or more emitters and two or more detectors, wherein a first detector of the two or more detectors is spaced apart from the two or more emitters a first distance and a second detector of the two or more detectors is spaced apart from the two or more emitters a second distance that is greater than the first distance, wherein the first electromagnetic radiation signal is received by the first detector of the two or more detectors and the second electromagnetic radiation signal is received by the second detector of the two or more detectors, and wherein the first electromagnetic radiation signal and the second electromagnetic radiation signal each comprise arterial pulses and venous pulses;

receive a first trigger signal having a first frequency corresponding to a periodic physical activity of a patient, wherein the first trigger signal is determined from the first electromagnetic radiation signal;

generate one or more first ensemble averaged signals based at least in part on the first and second electromagnetic radiation signals and the first trigger signal;

calculate a regional oxygen saturation value based at least in part on the one or more first ensemble averaged signals, wherein the regional oxygen saturation value corresponds to a blood oxygen saturation within venous, arterial, and capillary systems of a region of a patient'"'"'s tissue; and

display the regional oxygen saturation value on a display of the patient monitor.

16. The patient monitor of claim 15, wherein the first frequency of the first trigger signal corresponds to a cardiac cycle of the patient, and wherein the regional oxygen saturation value comprises a regional arterial oxygen saturation value.

17. The patient monitor of claim 16, wherein the one or more processor-executable routines, when executed, cause the processor to:

receive a second trigger signal having a second frequency corresponding to a respiratory cycle of the patient;

generate one or more second ensemble averaged signals based at least in part on the first and second electromagnetic radiation signals and the second trigger signal;

calculate a regional venous oxygen saturation value based at least in part on the one or more second ensemble averaged signals; and

display the regional venous oxygen saturation value on the display.

18. The patient monitor of claim 17, wherein the one or more processor-executable routines, when executed, cause the processor to:

determine a percentage of arterial blood in a region of the patient'"'"'s tissue;

determine a regional mixed oxygen saturation value based at least in part on the regional arterial oxygen saturation value, the regional venous oxygen saturation value, and the percentage; and

display the regional mixed oxygen saturation value on the display.

19. The patient monitor of claim 15, wherein the first frequency of the first trigger signal corresponds to a respiratory cycle of the patient, and wherein the regional oxygen saturation value comprises a regional venous oxygen saturation value.

20. The patient monitor of claim 15, wherein the one or more processor-executable routines, when executed, cause the processor to:

subtract the first electromagnetic radiation signal from the second electromagnetic radiation signal to generate a difference electromagnetic radiation signal; and

ensemble average the difference electromagnetic radiation signal utilizing the first trigger signal to generate the one or more ensemble averaged signals.