Methods of treating a thrombus in an artery using cyclical aspiration patterns

• US 10,342,655 B2
• Filed: 01/04/2019
• Issued: 07/09/2019
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Insera Therapeutics, Inc.
• Original Assignee: Insera Therapeutics, Inc.
• Inventors: Janardhan, Vallabh, Janardhan, Vikram
• Primary Examiner(s): Louis, Richard G
• Application Number:
  US16/239,903
• Publication Number:
  US 20190133746A1
• Time in Patent Office: 186 Days
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Abstract

Vascular treatment devices and methods include a woven structure including a plurality of bulbs that may be self-expanding, a hypotube, for example including interspersed patterns of longitudinally spaced rows of kerfs, and a bonding zone between the woven structure and the hypotube. The woven structure may include patterns of radiopaque filaments measurable under x-ray. Structures may be heat treated to include various shapes at different temperatures. The woven structure may be deployable to implant in a vessel. A catheter may include a hypotube including interspersed patterns of longitudinally spaced rows of kerfs and optionally a balloon. Laser cutting systems may include fluid flow systems.

Claims

1. A method of treating a thrombus in an artery using a repetitive cyclical pattern for aspiration, the method comprising:

inserting a distal end of a catheter into the artery, wherein the thrombus is distal to the distal end of the catheter, the catheter being a microcatheter, a distal access microcatheter, or a guide catheter, the thrombus causing acute ischemic stroke due to occlusion of the artery;

choosing the cyclical pattern from a plurality of stored cyclical patterns, the cyclical pattern comprising repetition of a first suction level, a second suction level different than the first suction level;

aspirating the thrombus using negative pressure through the catheter, the negative pressure varying according to the chosen cyclical pattern generated by power electronics of an automated negative suction device; and

arresting flow in the artery including inflating a balloon proximal to the thrombus and stopping anterograde forward flow proximal to the thrombus during aspirating the thrombus.

2. The method of claim 1, wherein the cyclical pattern comprises a crescendo suction pattern or a diminuendo suction pattern.

3. The method of claim 1, wherein the cyclical pattern comprises a third suction level different than the first suction level and the second suction level.

4. A method of treating a thrombus in an artery using a repetitive cyclical pattern for aspiration, the method comprising:

inserting a distal end of a catheter into the artery, wherein the thrombus is distal to the distal end of the catheter, the catheter being a microcatheter, a distal access microcatheter, or a guide catheter;

selecting the cyclical pattern from a plurality of stored cyclical patterns, the cyclical pattern comprising repetition of a first suction level and a second suction level different than the first suction level; and

aspirating the thrombus using negative pressure through the catheter, the negative pressure varying according to the selected cyclical pattern generated by power electronics of an automated negative suction device.

5. The method of claim 4, wherein the thrombus causes acute ischemic stroke due to occlusion of the artery.

6. The method of claim 4, wherein the cyclical pattern comprises a third suction level different than the first suction level and the second suction level.

7. The method of claim 4, wherein the cyclical pattern comprises a crescendo suction pattern or a diminuendo suction pattern.

8. The method of claim 4, wherein the catheter comprises a cut hypotube, a plurality of woven filaments, and a biomedical polymer, has an outer diameter between approximately 1.67 mm and 3 mm, and has a length between 45 cm and 150 cm.

9. The method of claim 4, wherein a duration of the first suction level is the same as a duration of the second suction level.

10. The method of claim 4, wherein a duration of the first suction level is different than a duration of the second suction level.

11. The method of claim 4, wherein the thrombus causes acute ischemic stroke due to occlusion of the artery, wherein the cyclical pattern comprises a crescendo suction pattern or a diminuendo suction pattern, and wherein a duration of the first suction level is different than a duration of the second suction level.

12. A method of treating a thrombus in an artery using a repetitive cyclical pattern for aspiration, the method comprising:

inserting a distal end of a catheter into the artery, wherein the thrombus is distal to the distal end of the catheter;

selecting the cyclical pattern from a plurality of provided cyclical patterns or creating the cyclical pattern, the cyclical pattern comprising repetition of a first suction level and a second suction level different than the first suction level; and

aspirating the thrombus using negative pressure through the catheter, the negative pressure varying according to the selected or created cyclical pattern generated by power electronics of an automated negative suction device.

13. The method of claim 12, wherein the thrombus causes acute ischemic stroke due to occlusion of the artery.

14. The method of claim 12, wherein the cyclical pattern comprises a third suction level different than the first suction level and the second suction level.

15. The method of claim 12, wherein the cyclical pattern comprises a crescendo suction pattern or a diminuendo suction pattern.

16. The method of claim 12, further comprising arresting flow in the artery including inflating a balloon proximal to the thrombus and stopping anterograde forward flow proximal to the thrombus during aspirating the thrombus.

17. The method of claim 12, wherein the catheter comprises a cut hypotube, a plurality of woven filaments, and a biomedical polymer, has an outer diameter between approximately 1.67 mm and 3 mm, and has a length between 45 cm and 150 cm.

18. The method of claim 12, wherein a duration of the first suction level is the same as a duration of the second suction level.

19. The method of claim 12, wherein a duration of the first suction level is different than a duration of the second suction level.

20. The method of claim 12, wherein the thrombus causes acute ischemic stroke due to occlusion of the artery, wherein the cyclical pattern comprises a crescendo suction pattern or a diminuendo suction pattern, and wherein a duration of the first suction level is different than a duration of the second suction level.